Make up your mind! - Dissociating the roles of orbitofrontal cortex and striatum in human decision making. How we make everyday decisions is a crucial behaviour of humans but the underlying processes in the brain are still poorly understood. This project will investigate what the roles of specific brain regions are in human decision making, which enable us to gain a better understanding of how these brain structures contribute to our decisions.
Fake News and Post-Truth Impacts: Responses to Conflictive Uncertainty. Attributions of fake news and post-truth are symptoms of uncertainty arising from conflicting information. Little is known about human responses to conflictive uncertainty other than that people find it aversive. This project aims to identify the determinants of human attitudes towards conflictive uncertainty. The aims will be achieved via the development of measures of attitudes toward conflictive uncertainty, and studies i ....Fake News and Post-Truth Impacts: Responses to Conflictive Uncertainty. Attributions of fake news and post-truth are symptoms of uncertainty arising from conflicting information. Little is known about human responses to conflictive uncertainty other than that people find it aversive. This project aims to identify the determinants of human attitudes towards conflictive uncertainty. The aims will be achieved via the development of measures of attitudes toward conflictive uncertainty, and studies identifying the major influences thereof. Expected outcomes include advances in knowledge of how conflictive uncertainty attitudes relate to risk orientations, personality, and situational factors. Anticipated benefits include improved strategies for decision makers and communicators faced with conflictive uncertainty.Read moreRead less
Decoding change of mind decisions and errors from brain activity in humans. This project intends to provide new insights into how the brain changes a decision to achieve better outcomes. Decision-making is rarely optimal, and in a dynamic world people must often change their initial decisions in order to avoid consequential errors. This project aims to investigate the neural mechanisms underlying such change-of-mind decisions and decision errors in humans. To this end, it plans to use novel deco ....Decoding change of mind decisions and errors from brain activity in humans. This project intends to provide new insights into how the brain changes a decision to achieve better outcomes. Decision-making is rarely optimal, and in a dynamic world people must often change their initial decisions in order to avoid consequential errors. This project aims to investigate the neural mechanisms underlying such change-of-mind decisions and decision errors in humans. To this end, it plans to use novel decoding techniques to predict the evolution of change-of-mind decisions from brain activity while decisions unfold. This approach would clarify how quality of information, effort, and reward are integrated at a neural level to bias people towards changing their decisions. The expected results would provide an improved understanding of the neural dynamics of errors and how the brain corrects decisions online to achieve better outcomes.Read moreRead less
The brain in real time: a neural model of rhythmic action and perception. This project aims to study a fundamental function of the human brain: its temporal architecture. It will provide an innovative perspective on the neural mechanisms underlying and relating perception, intention, and voluntary action in real time, though a combination of eye-tracking, behaviour, and neural recordings. By providing a common language with which to relate perception, cognition, volition and action, this will ....The brain in real time: a neural model of rhythmic action and perception. This project aims to study a fundamental function of the human brain: its temporal architecture. It will provide an innovative perspective on the neural mechanisms underlying and relating perception, intention, and voluntary action in real time, though a combination of eye-tracking, behaviour, and neural recordings. By providing a common language with which to relate perception, cognition, volition and action, this will provide significant benefits that will transform the way we think about brain function.Read moreRead less
I like you and I just can't help it: Explaining automatic affective responses. Our automatic affective responses are crucial in determining how we behave particularly in situations where there is little conscious deliberation. These automatic responses have been implicated in dysfunctional behaviours such as unhealthy food choices and racial bias. However very little research has investigated the psychological processes responsible for the formation of these automatic affective responses. The ai ....I like you and I just can't help it: Explaining automatic affective responses. Our automatic affective responses are crucial in determining how we behave particularly in situations where there is little conscious deliberation. These automatic responses have been implicated in dysfunctional behaviours such as unhealthy food choices and racial bias. However very little research has investigated the psychological processes responsible for the formation of these automatic affective responses. The aim of this project is to investigate the role of conditioning and cognitive processes in the formation and expression of automatic affective responses. This will allow for the development of novel interventions targeting automatic responses which contribute to dysfunctional behaviour. Read moreRead less
Predicting Behaviour from Brain Representations. This project aims to advance our understanding of how perceptual information is represented in the human brain and to link the structure of perceptual brain representations to human behaviour. The project plans to use complementary methods for recording brain activity (human neuroimaging and primate single-cell neurophysiology) and cutting-edge analytic techniques to generate a predictive model of behaviour based on the structure of perceptual bra ....Predicting Behaviour from Brain Representations. This project aims to advance our understanding of how perceptual information is represented in the human brain and to link the structure of perceptual brain representations to human behaviour. The project plans to use complementary methods for recording brain activity (human neuroimaging and primate single-cell neurophysiology) and cutting-edge analytic techniques to generate a predictive model of behaviour based on the structure of perceptual brain representations. It is anticipated that the results will significantly advance the field of cognitive neuroscience by providing a novel empirical framework for understanding how brain representations are predictive of behaviour.Read moreRead less
Cognitive flexibility from adolescence to senescence: variability associated with cognitive strategy and brain connectivity. Healthy living in our complex and unpredictable world depends on the ability to flexibly adjust to novelty and change. This project will study how cognitive flexibility changes from adolescence to senescence, identify the brain networks that mediate this change and explore the implications for successful adaptation in everyday life.
Improving performance in high risk environments using guided distraction and iconic cues. This project tests a novel strategy to assist operators in high-risk automated environments, in order to maintain their performance in low workload situations. Using guided distraction, this project will be able to show improvements in attention to critical tasks and in overall system performance, thereby reducing the potential for error.
PET imaging of learning-related plasticity in awake behaving rats. The objective of the project is to combine an investigation of basic learning paradigms with functional Positron emission tomography (PET) imaging in rats in order to answer critical questions about the neurobiological basis of learning and decision-making in the brain. MicroPET technology provides PET images without the confounds induced by anaesthesia. Using this technology, the project intends to observe whole-brain changes in ....PET imaging of learning-related plasticity in awake behaving rats. The objective of the project is to combine an investigation of basic learning paradigms with functional Positron emission tomography (PET) imaging in rats in order to answer critical questions about the neurobiological basis of learning and decision-making in the brain. MicroPET technology provides PET images without the confounds induced by anaesthesia. Using this technology, the project intends to observe whole-brain changes in dopamine neurotransmission in awake, behaving rats while they learn to predict motivationally relevant outcomes based on environmental cues and on their own actions (ie during Pavlovian and instrumental conditioning, respectively). The outcomes of this research may improve our understanding of the neural changes responsible for debilitating disorders of the brain and mind.Read moreRead less
Hippocampal regulation of goal-directed decision-making. The hippocampus is a part of the brain that is central to learning and memory yet little is known about its role in decision-making. It is the aim of this application to provide the first detailed, causal evidence of hippocampal regulation of decision-making. This is significant because many mental health disorders and dementias that involve decision-making deficits are characterised by hippocampal dysfunction, but any direct link between ....Hippocampal regulation of goal-directed decision-making. The hippocampus is a part of the brain that is central to learning and memory yet little is known about its role in decision-making. It is the aim of this application to provide the first detailed, causal evidence of hippocampal regulation of decision-making. This is significant because many mental health disorders and dementias that involve decision-making deficits are characterised by hippocampal dysfunction, but any direct link between these factors is unknown. The outcomes of the current grant will provide the first evidence of that link, thus providing deeper understanding of the neurophysiological mechanisms of these disorders, which could eventuate in the creation of more beneficial treatments. Read moreRead less