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Faecal Microbiota Transplantation For Active Ulcerative Colitis - A Randomised Controlled Trial: Clinical, Microbial & Immune Outcomes
Funder
National Health and Medical Research Council
Funding Amount
$700,126.00
Summary
This is a placebo controlled clinical trial to see whether giving healthy donor faeces to people with active ulcerative colitis can get them into remission. We will also examine how long the donor microbiome stays in the recipients stool, and examine the effects of faecal transplantation on the immune response in the lining of the colon in recipients.
Kava For The Treatment Of Generalized Anxiety Disorder: A 16-Week Double-Blind RCT
Funder
National Health and Medical Research Council
Funding Amount
$680,489.00
Summary
Herbal medicines play a prominent role in traditional medicine to treat affective disorders (mood and anxiety disorders), however scientific studies are needed to truly assess their effectiveness. This clinical trial is examining the anxiolytic efficacy of Kava in treating chronic anxiety. As current response to antidepressant drugs can be inadequate, Kava may offer an additional affordable, safe, and effective option to reduce anxiety.
Bioproduction and bioavailability of steroidal saponins, bioactives in herbal medicines. Steroidal saponins are a class of natural products that are common constituents of many herbal medicines and have been associated with many biological activities. Comprehensive studies into their biological activities are hampered by the small quantities available through isolation and the complexity of synthesis. The aim of this project is to identify, isolate and express the biosynthetic genes responsible ....Bioproduction and bioavailability of steroidal saponins, bioactives in herbal medicines. Steroidal saponins are a class of natural products that are common constituents of many herbal medicines and have been associated with many biological activities. Comprehensive studies into their biological activities are hampered by the small quantities available through isolation and the complexity of synthesis. The aim of this project is to identify, isolate and express the biosynthetic genes responsible for the critical steps in the synthesis of these compounds in the herbs themselves. This will allow for production of steroidal saponins using the isolated enzymes, facilitate biological studies and allow the production of critical standards required by the herbal industry for validation and regulation of herbal extracts.Read moreRead less
Studying the impact of pulsed magnetic fields on neural tissue. This project will determine the optimal parameters of pulsed magnetic fields for treating the ageing and/or damaged brain. The safety features, low cost and compact size of the medical device being investigated maximise compliance and make it relevant to populations in remote and rural areas.
Evaluating viscum album in tumour eradication strategies. Extracts from the plant parasite mistletoe are, internationally, the most widely used complementary cancer treatments. Providing clear evidence-based research, this project will focus on enhancing mistletoe anti-cancer treatment through the development of novel liposome-based tumour therapies.
Mechanism of synergy of ingredients in natural products and functional foods. Synergism is the interaction of two substances to produce an effect larger than the sum of the separate effects. This project aims to determine the basic biological mechanisms or molecular targets by which the synergy is occurring and to identify the bioactive compounds involved. Understanding how synergism works should help us to identify other synergistic compounds, allowing optimization of products for better effica ....Mechanism of synergy of ingredients in natural products and functional foods. Synergism is the interaction of two substances to produce an effect larger than the sum of the separate effects. This project aims to determine the basic biological mechanisms or molecular targets by which the synergy is occurring and to identify the bioactive compounds involved. Understanding how synergism works should help us to identify other synergistic compounds, allowing optimization of products for better efficacy and quality, and leading to new products that have a significant market advantage over currently available products. This project will help to develop improved natural products that could push this industry advantage further.Read moreRead less
Navigating back pain care: a sociological study of women's illness pathways within and between intersecting social worlds. Back pain affects most people at some point in their life. It is difficult to treat, choosing a provider can be confusing, and it is costly for the Government. This project will provide comprehensive data on women's journeys through back pain care, their experiences of different providers, and how they negotiate competing ideological perspectives.
Neuroimaging changes underpinning improvements in cognition in the elderly. Natural supplements are often used to improve brain and cognitive function, however, we do not know how these supplements work in the brain. Using novel brain imaging scans, the project will investigate whether 12-month administration of two promising natural supplements improves brain markers of ageing and cognitive decline in an elderly population.
Does A Whey-Protein And Vitamin D Enriched Drink Enhance The Health Benefits Of The Lift For Life® Resistance Training Program In Older Adults With Type 2 Diabetes?
Funder
National Health and Medical Research Council
Funding Amount
$572,023.00
Summary
Since type 2 diabetes is projected to affect over 1.8 million Australians by 2025, there is an urgent need to identify safe and acceptable population-based strategies to improve glucose metabolism and related cardiometabolic risks factors which are common in this population. This study will examine whether increased dietary protein and vitamin D treatment can enhance the effects of resistance training on body composition, glycaemic control and cardiometabolic risk factors in older adults with ty ....Since type 2 diabetes is projected to affect over 1.8 million Australians by 2025, there is an urgent need to identify safe and acceptable population-based strategies to improve glucose metabolism and related cardiometabolic risks factors which are common in this population. This study will examine whether increased dietary protein and vitamin D treatment can enhance the effects of resistance training on body composition, glycaemic control and cardiometabolic risk factors in older adults with type 2 diabetes.Read moreRead less
Investigation Of Australian And Papua New Guinean Traditional Medicines For Drug Discovery And Cultural Preservation
Funder
National Health and Medical Research Council
Funding Amount
$373,751.00
Summary
This project addresses the growing need for new antimicrobial agents by utilising the traditional medicinal floral knowledge of indigenous communities of Australia and Papua New Guinea. Discoveries from the biological and chemical investigations of traditional medicines used by these communities for treatment of microbial infections will indicate their potential to be used as clinical agents. Benefit sharing and capability building opportunities for the communities involved will also be key outc ....This project addresses the growing need for new antimicrobial agents by utilising the traditional medicinal floral knowledge of indigenous communities of Australia and Papua New Guinea. Discoveries from the biological and chemical investigations of traditional medicines used by these communities for treatment of microbial infections will indicate their potential to be used as clinical agents. Benefit sharing and capability building opportunities for the communities involved will also be key outcomes.Read moreRead less