Deciphering lipid-RNA nanocarrier structure upon RNA complexation. This project aims to decipher the nanostructure evolution, at a millisecond timescale, of lipid self-assembly upon coupling with RNAs and track the nanocarrier structural changes induced by biologically relevant acidic environments. This project will generate new knowledge of the interplay between the self-assembled lipid-RNA nanostructures and cellular objects for successful payload release. The expected outcome of this project ....Deciphering lipid-RNA nanocarrier structure upon RNA complexation. This project aims to decipher the nanostructure evolution, at a millisecond timescale, of lipid self-assembly upon coupling with RNAs and track the nanocarrier structural changes induced by biologically relevant acidic environments. This project will generate new knowledge of the interplay between the self-assembled lipid-RNA nanostructures and cellular objects for successful payload release. The expected outcome of this project is identification of the fundamental mechanisms of lipid-RNA molecular self-assembly and intracellular nucleic acid delivery. This should provide significant advances in the field of lipid nanoparticle engineering for the delivery of RNA therapeutics. Read moreRead less
Resolving surface nanobubbles as cavitation nuclei. This project aims to investigate the onset and control of cavitation, a challenging problem for over half a century. Cavitation is a process of bubble growth and subsequent collapse, and causes noise and damage to adjacent surfaces, e.g. the failure of ship propellers and valves. This project expects to unravel the mystery of cavitation nuclei, and to develop cavitation-free designs to mitigate the cavitation caused damage to propellers and val ....Resolving surface nanobubbles as cavitation nuclei. This project aims to investigate the onset and control of cavitation, a challenging problem for over half a century. Cavitation is a process of bubble growth and subsequent collapse, and causes noise and damage to adjacent surfaces, e.g. the failure of ship propellers and valves. This project expects to unravel the mystery of cavitation nuclei, and to develop cavitation-free designs to mitigate the cavitation caused damage to propellers and valves, and noise. The anticipated outcomes will significantly advance existing fundamental knowledge at the forefront of fluid physics and provide Australia with a significant advantage in the marine, pump and valve industries, and significantly benefit the Australian industry and economy. Read moreRead less