Improving the stability of biomolecules using ionic liquids. This project aims to address critical issues in studying proteins outside their native environments by developing new solvents that will increase their stability and solubility. The project expects to create new knowledge in our understanding of solvent chemical properties through a novel approach using high throughput robotics, synchrotron analysis of protein structures and Molecular Dynamics simulations. The expected outcome is a set ....Improving the stability of biomolecules using ionic liquids. This project aims to address critical issues in studying proteins outside their native environments by developing new solvents that will increase their stability and solubility. The project expects to create new knowledge in our understanding of solvent chemical properties through a novel approach using high throughput robotics, synchrotron analysis of protein structures and Molecular Dynamics simulations. The expected outcome is a set of design rules for creating new solvents. This should benefit many research and industrial applications, including determining protein structure for the development of new drugs and biocatalysts, and cryopreservation of protein-based pharmaceuticals.Read moreRead less
Deciphering ion specificity in complex electrolytes . This project aims to understand how ions influence the behaviour and properties of complex electrolytes (solutions containing either multiple ions, solvent mixtures, high electrolyte concentrations or a variety of interfaces, solutes or polymers). Complex electrolytes are ubiquitous in colloidal and particle technologies and underpin industrial and natural processes. Our team will combine experiment, simulation and theory to deliver a univers ....Deciphering ion specificity in complex electrolytes . This project aims to understand how ions influence the behaviour and properties of complex electrolytes (solutions containing either multiple ions, solvent mixtures, high electrolyte concentrations or a variety of interfaces, solutes or polymers). Complex electrolytes are ubiquitous in colloidal and particle technologies and underpin industrial and natural processes. Our team will combine experiment, simulation and theory to deliver a universal framework for understanding and predicting specific ion effects in complex electrolytes. The project outcomes are expected to deliver new understanding for researchers, robust rules of thumb for technologists and a public resource for data-driven solutions in applications utilising salt solutions. Read moreRead less