New Enantiomeric Separation Technologies for Natural Product, Pharmaceuticals and Environmental Pollutant Characterisation. Enantiomeric characterisation allows evaluation of drug purity for potentially harmful constituents, consumer protection against adulteration of essential oils and natural materials, and study of chemical interactions in biochemical/environmental systems. Chromatograph technologies (GC, HPLC and CE)for enantioseparation are available, however limitations prevent multicompon ....New Enantiomeric Separation Technologies for Natural Product, Pharmaceuticals and Environmental Pollutant Characterisation. Enantiomeric characterisation allows evaluation of drug purity for potentially harmful constituents, consumer protection against adulteration of essential oils and natural materials, and study of chemical interactions in biochemical/environmental systems. Chromatograph technologies (GC, HPLC and CE)for enantioseparation are available, however limitations prevent multicomponent characterisation of complete sample mixtures. Critical choices involve: choosing a chiral selector that interacts differentially upon all enantiomers; incorporation of selector into high-efficiency chromatographic systems; application to all target compounds in the sample. We will synthesise novel chiral selectors, incorporate these into new separation columns, apply ultra-high resolution 2-dimensional GCxGC to broad-spectrum chiral analysis of volatile chemical samples.Read moreRead less
Microreactors for Organic Synthesis. Since the electronic revolution, miniaturisation has been the trend for devices from consumer electronics to scientific instruments. In this time very little has changed in the manner, or scale, that synthetic organic chemistry has been carried out even though advances in instrumentation mean that less compound is required for identification and analysis. This project aims to bridge the gap by developing recyclable miniaturised reaction vessels for the format ....Microreactors for Organic Synthesis. Since the electronic revolution, miniaturisation has been the trend for devices from consumer electronics to scientific instruments. In this time very little has changed in the manner, or scale, that synthetic organic chemistry has been carried out even though advances in instrumentation mean that less compound is required for identification and analysis. This project aims to bridge the gap by developing recyclable miniaturised reaction vessels for the formation of organic compounds on a scale thousands of times smaller than it is currently done. These devices will have applications in drug discovery programmes due to higher throughput and increased efficiency while minimising waste.Read moreRead less
Probing and Developing Hypoxia-Selective Anti-Cancer Agents. The development of compounds that are effective in the treatment of cancer and are less toxic than existing drugs depends on the selective targeting of tumours. Solid tumours have poorly oxygenated regions which represent unique chemical environments that can be targeted using selectively activated compounds. In this project we will develop the first in situ methods for monitoring the activation state in solid tumours to establish the ....Probing and Developing Hypoxia-Selective Anti-Cancer Agents. The development of compounds that are effective in the treatment of cancer and are less toxic than existing drugs depends on the selective targeting of tumours. Solid tumours have poorly oxygenated regions which represent unique chemical environments that can be targeted using selectively activated compounds. In this project we will develop the first in situ methods for monitoring the activation state in solid tumours to establish the selectivity of activation. These results will be used to tune the properties of two novel classes of selectively activated compounds and thereby develop agents able to treat the most problematic of cancers.Read moreRead less
Composite nanomaterials for environmental remediation and fuel cell applications. Australia, in response to a mounting global awareness, needs to find cost effective energy storage sources to replace fossil fuels. The program will significantly add to research that provides fundamental advances in energy storage, in the form of fuel cells, and in the remediation of organic pollutants. It will also contribute to the future development of technologies in these areas that will have substantial ben ....Composite nanomaterials for environmental remediation and fuel cell applications. Australia, in response to a mounting global awareness, needs to find cost effective energy storage sources to replace fossil fuels. The program will significantly add to research that provides fundamental advances in energy storage, in the form of fuel cells, and in the remediation of organic pollutants. It will also contribute to the future development of technologies in these areas that will have substantial benefits to the broader community. The program will provide expert training for future chemists and connect them into leading international research groups led by our PIs.Read moreRead less
Development of Methods and Strategies for the Measurement, Interpretation and Analysis of Diffuse X-ray Scattering from Disordered Materials. This application seeks to exploit our established lead in the measurement of diffuse scattering from disordered materials and its analysis using large-scale computer simulations. Many industrially important materials such as ceramics, superconductors, catalysts, electro-optical materials and minerals owe their special properties to the disorder in their st ....Development of Methods and Strategies for the Measurement, Interpretation and Analysis of Diffuse X-ray Scattering from Disordered Materials. This application seeks to exploit our established lead in the measurement of diffuse scattering from disordered materials and its analysis using large-scale computer simulations. Many industrially important materials such as ceramics, superconductors, catalysts, electro-optical materials and minerals owe their special properties to the disorder in their structure. This disorder causes diffuse X-ray scattering which can be probed using synchrotron X-rays and powerful computers to reveal details about the material's nanoscale structure. The new methodology being developed will enhance our detailed understanding of the relationships between structure and properties in materials and help promote the design of new materials. Read moreRead less
Surfactant Self-Assembly in Ionic Liquids. Room temperature ionic liquids have emerged recently as important environmentally-friendly solvents for synthesis, catalysis, and electrochemical applications. This project will generate significant new fundamental understanding, and train young researchers in the use of RTILs and advanced characterization techniques at honours, postgraduate and postdoctoral levels. The results of this project will enable the development of new technologies by adaptin ....Surfactant Self-Assembly in Ionic Liquids. Room temperature ionic liquids have emerged recently as important environmentally-friendly solvents for synthesis, catalysis, and electrochemical applications. This project will generate significant new fundamental understanding, and train young researchers in the use of RTILs and advanced characterization techniques at honours, postgraduate and postdoctoral levels. The results of this project will enable the development of new technologies by adapting water-based surfactant technologies to a range of low-volatility RTILs. Examples include new mesoporous catalysts, nanostructured self-assembled scaffolds and composite materials, nanoparticle synthesis, novel lubricants and drug-delivery systems.Read moreRead less
Adsorption and Structure at Ionic Liquid Interfaces. Ionic liquids (ILs) have recently emerged as important environmentally-friendly solvents for synthesis, but applications based on their unusual physical properties have been vastly under-exploited. This project will generate significant new fundamental understanding of ILs, and train young researchers in the use of ILs and advanced characterization techniques at honours, postgraduate and postdoctoral levels. The results of this project will en ....Adsorption and Structure at Ionic Liquid Interfaces. Ionic liquids (ILs) have recently emerged as important environmentally-friendly solvents for synthesis, but applications based on their unusual physical properties have been vastly under-exploited. This project will generate significant new fundamental understanding of ILs, and train young researchers in the use of ILs and advanced characterization techniques at honours, postgraduate and postdoctoral levels. The results of this project will enable the development of new or improved technologies by facilitating the use of ILs in specialised products. Examples include novel lubricants, catalytic mediums, surface coatings, nanostructured self-assembled scaffolds and composite materials, nanoparticle synthesis, and drug-delivery systems.Read moreRead less
Chemical Insights to Peptide Helix-Sheet-Nanofibre Equilibria. We live in an ageing community that is experiencing exponential growth in neurological diseases that require full time carers and place significant burdens on our health system. Many such diseases are caused by (apparently) abnormal folding of proteins that aggregate into insoluble materials. The chemistry behind these processes is not sufficiently well understood to know precisely why the diseases are caused and how they might be tr ....Chemical Insights to Peptide Helix-Sheet-Nanofibre Equilibria. We live in an ageing community that is experiencing exponential growth in neurological diseases that require full time carers and place significant burdens on our health system. Many such diseases are caused by (apparently) abnormal folding of proteins that aggregate into insoluble materials. The chemistry behind these processes is not sufficiently well understood to know precisely why the diseases are caused and how they might be treated. This project will use new strategies to control peptide folding, provide important new information relevant to understanding such processes/diseases, and teach us how to engineer important new biomaterials that can advance nanotechnology. Read moreRead less
Catalytic currency: the role of size-reactivity relationships of simple and mixed 'coinage' metal clusters in C-C bond forming reactions. Chemicals have a profound influence on our daily lives. For instance, the petrol we use in our cars, the plastics used for our shopping bags or the margarine we eat. A common theme of all these products is the use of catalysts in their industrial manufacture. Thus, this Australian Research Council funded project aims to shed light on the role of some catalysts ....Catalytic currency: the role of size-reactivity relationships of simple and mixed 'coinage' metal clusters in C-C bond forming reactions. Chemicals have a profound influence on our daily lives. For instance, the petrol we use in our cars, the plastics used for our shopping bags or the margarine we eat. A common theme of all these products is the use of catalysts in their industrial manufacture. Thus, this Australian Research Council funded project aims to shed light on the role of some catalysts in breaking and forming chemical bonds and attempts to set rules to develop new and improved ones. Improved catalysts will not only reduce the cost of goods manufacturing, but will also reduce waste products and energy consumption. This research will also train new scientists and contribute to the enhancement of Australia's research profile.Read moreRead less
Novel nanostructured InVO4 and related vanadates photocatalysts for water splitting under visible light irradiation. This proposal is at the forefront of a number of important fields, and therefore the outcomes are expected to be of great interest to a broad spectrum of industry sectors, including sustainable energy supply, solar energy applications, and environmental purification. This novel material system could lead to highly efficient photocatalysts for application in solar energy to split w ....Novel nanostructured InVO4 and related vanadates photocatalysts for water splitting under visible light irradiation. This proposal is at the forefront of a number of important fields, and therefore the outcomes are expected to be of great interest to a broad spectrum of industry sectors, including sustainable energy supply, solar energy applications, and environmental purification. This novel material system could lead to highly efficient photocatalysts for application in solar energy to split water to produce hydrogen. The outcomes of this project will position Australian researchers among the pioneering groups in this area and will benefit several major technology-related fields including sustainable energy supply, environmental protection engineering, and materials manufacture technology.Read moreRead less