The Scale-up and Evaluation of a Novel Dense Gas Technology Platform for the Production of Particles for Aerosol Drug Delivery. This project provides a unique opportunity to develop an Australian-invented technology in particle engineering, enabling it to enter the international pharmaceutical market. This will enhance the growth of Australia's pharmaceutical research and development, and benefit the Australian pharmaceutical industry. The outcome will also contribute to improvements in the heal ....The Scale-up and Evaluation of a Novel Dense Gas Technology Platform for the Production of Particles for Aerosol Drug Delivery. This project provides a unique opportunity to develop an Australian-invented technology in particle engineering, enabling it to enter the international pharmaceutical market. This will enhance the growth of Australia's pharmaceutical research and development, and benefit the Australian pharmaceutical industry. The outcome will also contribute to improvements in the health and well-being of Australians. The research falls within the Designated National Research Priority of Frontier Technologies for Building and Transforming Australian Industries.Read moreRead less
Characterization and optimisation of Myomatrix: A novel extracellular matrix hydrogel from muscle. This project would have several sources of benefit for the community. Foremost we will have produced a product that will have a strong commercial application in several fields including basic science and bioengineering. If its full potential were achieved, the development of this innovative new hydrogel would strengthen Australia's standing in the biotechnology field and also enrich specific applic ....Characterization and optimisation of Myomatrix: A novel extracellular matrix hydrogel from muscle. This project would have several sources of benefit for the community. Foremost we will have produced a product that will have a strong commercial application in several fields including basic science and bioengineering. If its full potential were achieved, the development of this innovative new hydrogel would strengthen Australia's standing in the biotechnology field and also enrich specific applications. The knowledge gained from the characterization of this product could also be of benefit to several areas including chemical engineering, tissue engineering, tissue repair, polymer chemistry and food manufacture. The expertise generated and the possibility of collaboration, both academic and with industry would also benefit the community. Read moreRead less
Scalable, high throughput microfluidic platforms for tissue specific biomaterials development and tissue genesis. The co-development of novel biomaterial platforms and new generation production methods for tissue analogues will provide the necessary stimulus for improved and more relevant methods of enhanced repair or regeneration of diseased or damaged tissues. These outcomes will result in faster time-to-market new generation therapeutic products for Australia and the world. These advances wil ....Scalable, high throughput microfluidic platforms for tissue specific biomaterials development and tissue genesis. The co-development of novel biomaterial platforms and new generation production methods for tissue analogues will provide the necessary stimulus for improved and more relevant methods of enhanced repair or regeneration of diseased or damaged tissues. These outcomes will result in faster time-to-market new generation therapeutic products for Australia and the world. These advances will have a significant impact on our healthcare costs and the quality of life for all Australians.Read moreRead less
Mastering the Microenvironment - Integrated, functional, biosynthetic scaffolds for tissue engineering. Organ transplantation is available to only the lucky few, with, for example, less than 3000 of Australia's annual 30,000 patients suffering end-stage renal failure receiving transplants. Tissue engineering of soft, functional tissues using in vitro and/or in vivo methods offers the potential to replace missing or non-functioning tissues, such as liver, pancreas, lung, heart, fat and muscle, wi ....Mastering the Microenvironment - Integrated, functional, biosynthetic scaffolds for tissue engineering. Organ transplantation is available to only the lucky few, with, for example, less than 3000 of Australia's annual 30,000 patients suffering end-stage renal failure receiving transplants. Tissue engineering of soft, functional tissues using in vitro and/or in vivo methods offers the potential to replace missing or non-functioning tissues, such as liver, pancreas, lung, heart, fat and muscle, with newly created tissue. This project will deliver integrated, functional polymeric scaffolds for organ replacement. Over 12 higher degree candidates and one research associate will be trained in the field of tissue engineering, representing a significant benefit to the Australian scientific community.Read moreRead less
Innovative green technology for bio-particle engineering. Approximately 40% of new pharmaceuticals are poorly soluble in bodily fluids. In many cases this leads to poor bioavailability, and consequent undesirable side effects as a result of high compensating dosages and generally poor patient compliance. These issues will be addressed by developing a green technology for the re-engineering of pharmaceuticals with the objective of increasing bioavilability. The research programme falls within th ....Innovative green technology for bio-particle engineering. Approximately 40% of new pharmaceuticals are poorly soluble in bodily fluids. In many cases this leads to poor bioavailability, and consequent undesirable side effects as a result of high compensating dosages and generally poor patient compliance. These issues will be addressed by developing a green technology for the re-engineering of pharmaceuticals with the objective of increasing bioavilability. The research programme falls within the Designated Research Priority of Frontier Technologies for Building and Transforming Australian Industries. Read moreRead less
Engineering of cartilage-based biomaterials under dynamic culture conditions. This work contributes to the development of advanced technologies in the area of biomaterials. The cartilage biomaterials generated in this work will lead to new medical applications in tissue reconstruction and replacement, which is of direct benefit to society by improving the methods used to treat joint disease and injury. As there is a significant commercial market for tissue-engineered cartilage products, this res ....Engineering of cartilage-based biomaterials under dynamic culture conditions. This work contributes to the development of advanced technologies in the area of biomaterials. The cartilage biomaterials generated in this work will lead to new medical applications in tissue reconstruction and replacement, which is of direct benefit to society by improving the methods used to treat joint disease and injury. As there is a significant commercial market for tissue-engineered cartilage products, this research also has implications for enhancing the scope and profitability of the Australian biotechnology industry. The project will be a vehicle for research training in a broad range of interdisciplinary areas. Students involved in the work will be equipped with a versatile and valuable combination of skills.Read moreRead less