Controlled Crystallisation of Bioactives. The new technologies developed in this project for bioactive recovery and particle design will allow the development of new value added products for Australia's growing biotechnology industry, especially in pharmaceuticals, neutraceuticals and functional foods. Two PhD students will receive excellent research training to then move into research and development in these industries.
Numerical Modelling and Experimental Studies to Design and Engineer Nanoparticulate Systems for Bioapplications. Project outcomes will enhance Australia's reputation for scientific innovation in the field of bio-nanotechnology. The project will expand the knowledge base in this area and increase Australia's international profile in research on nanomaterials for bio-related applications. The project partners UNSW and Australian company (Minomic), integrating their skills, expertise and facilities ....Numerical Modelling and Experimental Studies to Design and Engineer Nanoparticulate Systems for Bioapplications. Project outcomes will enhance Australia's reputation for scientific innovation in the field of bio-nanotechnology. The project will expand the knowledge base in this area and increase Australia's international profile in research on nanomaterials for bio-related applications. The project partners UNSW and Australian company (Minomic), integrating their skills, expertise and facilities to address current limitations in understanding the stability of magnetic nanoparticles in biological fluids. The Australian partners will play a leading role in commercializing new applications for functionalized magnetic nanoparticles. The project will provide an excellent multidisciplinary research environment and training for early career researchers.Read moreRead less
Modelling of Adsorption Dynamics in Microporous Adsorbents Using Fractional Order Diffusion Equations. This project investigates the use of fractional order diffusion equations in modelling adsorption dynamics in microporous carbons. The long tail behaviour of adsorption processes cannot be readily explained by the classical second order Fickian model, and makes adsorption a candidate for the use of fractional order diffusion equations that have the potential to model such features. In the pre ....Modelling of Adsorption Dynamics in Microporous Adsorbents Using Fractional Order Diffusion Equations. This project investigates the use of fractional order diffusion equations in modelling adsorption dynamics in microporous carbons. The long tail behaviour of adsorption processes cannot be readily explained by the classical second order Fickian model, and makes adsorption a candidate for the use of fractional order diffusion equations that have the potential to model such features. In the present project we shall develop suitable numerical techniques for solving the fractional order diffusion model, and apply these to the interpretation of experimental kinetic data. The outcome will be an improved model of adsorption dynamics considering the fractal nature of the solid.Read moreRead less
Nanoporous bioaffinity adsorbents for separations in the pharmaceutical industry. This proposal aims to develop new high performance adsorbents for bioprocess engineering based on templated nanoporous silica materials. This research will lead to significant advances in advanced materials and adsorbent technology, downstream processing for the biotechnology industries, and understanding of highly specific affinity interactions used for difficult bioseparations. It will have important benefits for ....Nanoporous bioaffinity adsorbents for separations in the pharmaceutical industry. This proposal aims to develop new high performance adsorbents for bioprocess engineering based on templated nanoporous silica materials. This research will lead to significant advances in advanced materials and adsorbent technology, downstream processing for the biotechnology industries, and understanding of highly specific affinity interactions used for difficult bioseparations. It will have important benefits for processes involving protein purification, such as bioplasma processing, as well as flow on effects to other applications of adsorbent technology such as food processing and water treatment. The new adsorbents will lead to reductions in the costs, energy usage and waste generation of Australian industries.Read moreRead less
The Study of Pretreatment Options for Composite Fouling of Reverse Osmosis Membranes Used in Water Treatment and Production. It is recognised worldwide that fouling is a major impediment in operation of Reverse Osmosis units used for production, purification and treatment of water. This project is aimed at studying pre-treatment options for composite fouling which is the main type of fouling present in RO units by using both model feed systems and actual field water. The project outcomes are to ....The Study of Pretreatment Options for Composite Fouling of Reverse Osmosis Membranes Used in Water Treatment and Production. It is recognised worldwide that fouling is a major impediment in operation of Reverse Osmosis units used for production, purification and treatment of water. This project is aimed at studying pre-treatment options for composite fouling which is the main type of fouling present in RO units by using both model feed systems and actual field water. The project outcomes are to understand and develop pre-treatment strategies and to use those to develop a hybrid pre-treatment technology. This project will significantly impact water production in general and its outcomes will have far-reaching implications in treatment of water both within Australia and globally.Read moreRead less
Gas-phase and catalytic reaction of halons under reducing conditions. Halons are ozone-depleting substances, but their use continues in most countries. This project pursues techniques to convert, rather than destroy, halons into benign and useful products. The aims of this project are to gain a fundamental understanding of the reactions of the most commonly used halons, 1301, 1211 and 2402, and perform a detailed examination of catalytic processes for conversion of halons to HFCs. The primary ....Gas-phase and catalytic reaction of halons under reducing conditions. Halons are ozone-depleting substances, but their use continues in most countries. This project pursues techniques to convert, rather than destroy, halons into benign and useful products. The aims of this project are to gain a fundamental understanding of the reactions of the most commonly used halons, 1301, 1211 and 2402, and perform a detailed examination of catalytic processes for conversion of halons to HFCs. The primary outcome from the study will be the development of a process specifically designed to convert halons into useful products. This will assist with efforts to phase out continued halon use.Read moreRead less
Particle Design for Recovery and Delivery of Bioactives. This project will develop new strategies for economically viable recovery of bioactives from complex solutions, slurries and sludges of biomaterials eg. waste streams from milk and soy bean processing, and fermentation broths. These bioactives, often proteins, have growing applications as high value drugs, nutriceuticals and food additives but are difficult to separate and to maintain in an active form. Crystallisation will be used as a ....Particle Design for Recovery and Delivery of Bioactives. This project will develop new strategies for economically viable recovery of bioactives from complex solutions, slurries and sludges of biomaterials eg. waste streams from milk and soy bean processing, and fermentation broths. These bioactives, often proteins, have growing applications as high value drugs, nutriceuticals and food additives but are difficult to separate and to maintain in an active form. Crystallisation will be used as a primary separation technique. Molecular studies of protein interactions will be used to predict good crystallisation conditions and linked to process crystallisation studies. Both standard and novel particle design strategies will be used to control crystal size and morphology, as well as package the boactive in a deliverable form without loss of activity.Read moreRead less
Investigation and Prediction of the Novel Properties of Dendrimers. Dendrimers are a new class of highly branched polymers, which have, until now, been difficult to characterise by conventional means. This project will develop and apply molecular simulation techniques to reveal the chemical and physical properties of dendrimers and their interactions with other molecules. These novel molecules potentially have beneficial applications to areas such as drug delivery and electronic materials. Th ....Investigation and Prediction of the Novel Properties of Dendrimers. Dendrimers are a new class of highly branched polymers, which have, until now, been difficult to characterise by conventional means. This project will develop and apply molecular simulation techniques to reveal the chemical and physical properties of dendrimers and their interactions with other molecules. These novel molecules potentially have beneficial applications to areas such as drug delivery and electronic materials. The outcome of this work will assist in the exploitation of this beneficial application and will provide the basis for efficient processing.Read moreRead less
Economic Operability Assessment of Leaching Process at Kwinana Nickel Refinery. Process operability is concerned with systematic analysis and improvement of process performance in the face of variable operating conditions. This project will develop a rigorous methodology for analysis of process operability with respect to short-term and transient disturbances. The proposed technique will be applied to the Kwinana Nickel Refinery Leach section, in order to reduce the plant variability and increas ....Economic Operability Assessment of Leaching Process at Kwinana Nickel Refinery. Process operability is concerned with systematic analysis and improvement of process performance in the face of variable operating conditions. This project will develop a rigorous methodology for analysis of process operability with respect to short-term and transient disturbances. The proposed technique will be applied to the Kwinana Nickel Refinery Leach section, in order to reduce the plant variability and increase nickel throughput and plant availability. This can be considered as significant move by a process industry to embrace advanced theoretical developments and will act as a benchmark to promote future links between Australian industry and academia.Read moreRead less
New approaches to the treatment of potable water in the presence of algal blooms. The processing of blue green algae rich waters and subsequent release of algal metabolites causes taste and odour problems and toxins that affect potable water safety. This project will define a preferred approach to the processing of these waters and provide quantitative analysis tools to help water authorities guarantee water quality and safety. The defined process routes and analysis procedures will also resul ....New approaches to the treatment of potable water in the presence of algal blooms. The processing of blue green algae rich waters and subsequent release of algal metabolites causes taste and odour problems and toxins that affect potable water safety. This project will define a preferred approach to the processing of these waters and provide quantitative analysis tools to help water authorities guarantee water quality and safety. The defined process routes and analysis procedures will also result in better water conservation (lower net water losses in processing). This will allow better regulation of water quality, safety and management by water authorities and improve consumer confidence in the potable water supply.Read moreRead less