Engineered nanoporous materials and composites having hierarchical structures by emulsion templating. The project aims to develop new and flexible emulsion-templated processes capable of constructing novel nanoporous materials with hierarchical structures. The project has the potential to revolutionise current approaches for making porous materials, and the outcomes will enhance Australia's ability in frontier technologies and advanced materials.
Granular dynamics: characterization, modelling and application. Storage and transport of bulk solids are widely encountered in mineral, metallurgical and chemical industrials which are important to Australia. The design and control of bulk solids handling equipment must be optimised for the efficiency of processing. This project provides a systematic investigation of the techniques used to characterize bulk solids, and applies the new findings to hopper flow and pneumatic conveying. This, togeth ....Granular dynamics: characterization, modelling and application. Storage and transport of bulk solids are widely encountered in mineral, metallurgical and chemical industrials which are important to Australia. The design and control of bulk solids handling equipment must be optimised for the efficiency of processing. This project provides a systematic investigation of the techniques used to characterize bulk solids, and applies the new findings to hopper flow and pneumatic conveying. This, together with the research training offered through the conduct of the work, is very helpful to maintaining Australia’s leading position in bulk solids handling and application in resource, energy, process and allied industries.Read moreRead less
Particle-scale modelling of particle-fluid flows in gas and oil extraction. Particle-scale modelling of particle-fluid flows in gas and oil extraction. This project aims to develop a particle scale model to study the pipeline transport of petroleum fluids. It will use a combined theoretical and experimental program, involving state-of-the-art discrete element modelling and simulation techniques, to describe the complex particle-fluid flow and erosion of pipeline transport in gas and oil extracti ....Particle-scale modelling of particle-fluid flows in gas and oil extraction. Particle-scale modelling of particle-fluid flows in gas and oil extraction. This project aims to develop a particle scale model to study the pipeline transport of petroleum fluids. It will use a combined theoretical and experimental program, involving state-of-the-art discrete element modelling and simulation techniques, to describe the complex particle-fluid flow and erosion of pipeline transport in gas and oil extraction, quantify the effects of key variables, and formulate strategies for optimum process control under different conditions. The research outcomes are expected to be useful for the process control of pipeline transport in Australia’s important petroleum and energy-related industries.Read moreRead less
Immune-imprinting nanoparticles (iNPs). This research promises new classes of immune-imprinting, biodegradable nanoparticles (iNPs) with anti-inflammatory properties. The engineering of such particles requires fundamental understanding of their properties that enable specific cellular interactions to regulate immunity with new anti-inflammatory pathways. For pulmonary delivery, spray-dried amino acid microspheres with tailored surfaces as carriers can be generated using the innovative microfluid ....Immune-imprinting nanoparticles (iNPs). This research promises new classes of immune-imprinting, biodegradable nanoparticles (iNPs) with anti-inflammatory properties. The engineering of such particles requires fundamental understanding of their properties that enable specific cellular interactions to regulate immunity with new anti-inflammatory pathways. For pulmonary delivery, spray-dried amino acid microspheres with tailored surfaces as carriers can be generated using the innovative microfluidic drying approach. The potential applications of iNPs are wide-ranging and are not restricted to pulmonary targeting. The potential commercial implications for Australia's emerging biopharmaceutical industry are substantial.Read moreRead less
Unravelling the mechanics of particle deposition at the micro-scale. This project aims to discover the mechanisms responsible for the interactions between aerosol particles and surfaces in a range of air flow conditions. The project expects to transform our understanding of particle deposition through a combination of novel laser-based diagnostic techniques, optical coherence tomography, and state of the art particle formulation methodologies. Expected outcomes of the project include delivery of ....Unravelling the mechanics of particle deposition at the micro-scale. This project aims to discover the mechanisms responsible for the interactions between aerosol particles and surfaces in a range of air flow conditions. The project expects to transform our understanding of particle deposition through a combination of novel laser-based diagnostic techniques, optical coherence tomography, and state of the art particle formulation methodologies. Expected outcomes of the project include delivery of new methods to optimise particle deposition, development of tunable powder formulations, as well as definition of particle-surface interaction mechanisms in flows. The project should provide significant benefits to particle systems for applications ranging from additive manufacturing to aerosol delivery.Read moreRead less
Dynamic input adjustment to improve the stability of transient swirling flows in spray dryers. This project will use leading-edge numerical techniques to advance the science of flow stabilisation using dynamic flow modulation techniques. Improved sustainable processing will be enabled using this flow modulation in spray dryers to reduce processing problems due to the depositon of particles on dryer walls.
Scaling-up microfluidic drying as an efficient route to manufacture uniform and functional particles as high-value products. This project aims to scale-up microfluidic spray drying and demonstrate the method as a viable option to manufacture monodisperse microparticles as bioactive carriers or microencapsulates, with better functional properties and uniformity. It aims to transform the manufacturing of high-value products for pharmaceuticals, functional foods and biotechnology applications and l ....Scaling-up microfluidic drying as an efficient route to manufacture uniform and functional particles as high-value products. This project aims to scale-up microfluidic spray drying and demonstrate the method as a viable option to manufacture monodisperse microparticles as bioactive carriers or microencapsulates, with better functional properties and uniformity. It aims to transform the manufacturing of high-value products for pharmaceuticals, functional foods and biotechnology applications and lift productivity by managing innovation for Australia’s industries.Read moreRead less
Design a Targeted Delivery System for Probiotics. The project aims to improve the effectiveness of probiotics by developing a targeted delivery system to the colon. This interdisciplinary research will generate new knowledge in the field of microbiota and develop new delivery systems for live microorganisms and other active compounds. Expected outcomes include increased understanding of the factors affecting the viability of probiotics during storage and passage through the gastro-intestinal tra ....Design a Targeted Delivery System for Probiotics. The project aims to improve the effectiveness of probiotics by developing a targeted delivery system to the colon. This interdisciplinary research will generate new knowledge in the field of microbiota and develop new delivery systems for live microorganisms and other active compounds. Expected outcomes include increased understanding of the factors affecting the viability of probiotics during storage and passage through the gastro-intestinal tract, the establishment of probiotics into gut flora, and how this incorporation affects the dynamics of gut microbiota. The new technology can be utilised across a wide range of therapeutics that target the colon to promote the well-being of our society through commercialisation by industry partner.Read moreRead less
Engineering improved technology for nanoparticle-based adjuvant manufacture. Over the next decade nanotechnology will redefine vaccines for animal and human health. Nanoparticle adjuvants will boost engineered vaccines that use minimal antigens such as recombinant proteins and synthetic peptides. This project aims to develop a platform technology for making and controlling the properties of inulin nanoparticles by optimising the engineering and manufacturing aspects of inulin nanoparticles to fu ....Engineering improved technology for nanoparticle-based adjuvant manufacture. Over the next decade nanotechnology will redefine vaccines for animal and human health. Nanoparticle adjuvants will boost engineered vaccines that use minimal antigens such as recombinant proteins and synthetic peptides. This project aims to develop a platform technology for making and controlling the properties of inulin nanoparticles by optimising the engineering and manufacturing aspects of inulin nanoparticles to fundamentally understand the relationship between physical-chemical properties and efficacy. Completion of this project aims to produce potent nanoparticle-based adjuvants underpinned by novel manufacturing technology, to ultimately facilitate the development of more effective and protective vaccines for animals and humans.Read moreRead less
Mudstones as methane sources: gas production from coal seam interburden. Carbonaceous mudstones associated with coal measures already exploited for gas present an attractive reservoir of methane. This project seeks to provide methods for accessing this gas. Mudstone associated with coal seam gas developments are very extensive and gas quantities may exceed even that in the coal itself. Further infrastructure and access permits are already in place for coal seam gas recovery. Unlike shale, which ....Mudstones as methane sources: gas production from coal seam interburden. Carbonaceous mudstones associated with coal measures already exploited for gas present an attractive reservoir of methane. This project seeks to provide methods for accessing this gas. Mudstone associated with coal seam gas developments are very extensive and gas quantities may exceed even that in the coal itself. Further infrastructure and access permits are already in place for coal seam gas recovery. Unlike shale, which is fissile, mudstone is much softer, more malleable and plastic, and consequently will respond abnormally to hydraulic fracturing and propping, so new methods proposed to be developed in this project are needed for stimulation.Read moreRead less