Molecular Interactions of Chemical Agents with Ion-Channel Proteins. With a minimal number of functional units (proteins) viruses are able to replicate. All of these proteins are possible antiviral targets. In this project we wil1 focus on a short protein called Vpu found in membranes of the HIV-1 virus and aim to analyse the interaction of potential pore blocking compounds. It is essential to know exactly where they sit and how the overall structure of Vpu is affected. For this enterprise we wi ....Molecular Interactions of Chemical Agents with Ion-Channel Proteins. With a minimal number of functional units (proteins) viruses are able to replicate. All of these proteins are possible antiviral targets. In this project we wil1 focus on a short protein called Vpu found in membranes of the HIV-1 virus and aim to analyse the interaction of potential pore blocking compounds. It is essential to know exactly where they sit and how the overall structure of Vpu is affected. For this enterprise we will use nuclear magnetic resonance (NMR) spectroscopy. This information will serve as a springboard for future investigations of virus membrane proteins.
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Linkage Infrastructure, Equipment And Facilities - Grant ID: LE0668521
Funder
Australian Research Council
Funding Amount
$300,000.00
Summary
Small Angle Scattering Facility for the Materials and Biological Sciences. There are many benefits to the community from the application of modern technology for materials and protein characterisation, particularly one that is as broadly applicable as small angle scattering. For example, it can directly aid in the development of new materials for energy storage and generation, biomaterials for improved health and the process of design of drugs for many types of disease. This facility will ben ....Small Angle Scattering Facility for the Materials and Biological Sciences. There are many benefits to the community from the application of modern technology for materials and protein characterisation, particularly one that is as broadly applicable as small angle scattering. For example, it can directly aid in the development of new materials for energy storage and generation, biomaterials for improved health and the process of design of drugs for many types of disease. This facility will benefit a large number of researchers and significantly enhance the outcomes of recent investments in high quality pure and applied research.Read moreRead less
Structural determination of respiratory membrane protein complexes by X-ray crystallography. Membrane proteins form only 0.3% of the available protein structures in the protein data bank (PDB), yet 30% of the proteins in the human genome and 50% of human drug targets are membrane proteins. We have managed to increase the success rate through rational screening and development of new crystallization screens, with downstream implications for basic and medical research. Results from this proposal w ....Structural determination of respiratory membrane protein complexes by X-ray crystallography. Membrane proteins form only 0.3% of the available protein structures in the protein data bank (PDB), yet 30% of the proteins in the human genome and 50% of human drug targets are membrane proteins. We have managed to increase the success rate through rational screening and development of new crystallization screens, with downstream implications for basic and medical research. Results from this proposal will receive international recognition and will encourage more research in this field, attracting international funding, and create new research opportunities. Read moreRead less