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Neural circuit control of effort under stress . This Project aims to investigate how the ‘decision’ to persist in exerting effort to obtain a reward is encoded in the the brain and affected by stress. This work will generate new knowledge on the neural mechanisms through which stress modifies neural activity to control decision making processes underpinning adaptive behaviours essential for survival. The expected outcomes of this work include enhanced capacity at the interface of behavioural a ....Neural circuit control of effort under stress . This Project aims to investigate how the ‘decision’ to persist in exerting effort to obtain a reward is encoded in the the brain and affected by stress. This work will generate new knowledge on the neural mechanisms through which stress modifies neural activity to control decision making processes underpinning adaptive behaviours essential for survival. The expected outcomes of this work include enhanced capacity at the interface of behavioural and computational neuroscience, that will in turn provide significant benefits through greater insight into brain functions essential for survival, with long ranging implications for performance optimisation and brain-inspired computing. Read moreRead less
Midbrain hunger signalling modifies decision making under conflict. Decision-making is one of the most important and fundamental biological processes executed by the mammalian brain. Environmental threats and physiological pressures, such as hunger, can influence decision-making processes skewing the risk/reward ratio, yet how the brain integrates these conflicting goals to determine action selection is unknown. This project aims to investigate brain chemistry and circuitry controlling decision ....Midbrain hunger signalling modifies decision making under conflict. Decision-making is one of the most important and fundamental biological processes executed by the mammalian brain. Environmental threats and physiological pressures, such as hunger, can influence decision-making processes skewing the risk/reward ratio, yet how the brain integrates these conflicting goals to determine action selection is unknown. This project aims to investigate brain chemistry and circuitry controlling decision making under conflict using a multidisciplinary approach combining behaviour, pharmacogenetics, and sophisticated molecular and functional profiling. The expected outcomes will advance theories regarding the neural organisation and computation of decision making under conflict.Read moreRead less