Linkage Infrastructure, Equipment And Facilities - Grant ID: LE0775562
Funder
Australian Research Council
Funding Amount
$500,000.00
Summary
The Melbourne Nanofabrication Facility. Australia is desperately short of facilities for actual fabrication, prototyping and construction of advanced micromechanical and nanoscale systems. This is impeding both academic researchers and industrial developers in the materials, optics and biotechnological industries. The proposed instrument would complete the development of Australia's newest high resolution microscopy centre and enable a wide range of users to image, measure, build and design comp ....The Melbourne Nanofabrication Facility. Australia is desperately short of facilities for actual fabrication, prototyping and construction of advanced micromechanical and nanoscale systems. This is impeding both academic researchers and industrial developers in the materials, optics and biotechnological industries. The proposed instrument would complete the development of Australia's newest high resolution microscopy centre and enable a wide range of users to image, measure, build and design complex nanostructures at the atomic level and upwards. Read moreRead less
Breaking The Wavelength Barrier: Near-Field T-ray Imaging. Australia will benefit from the interaction between engineering, physics, and biology to develop a new T-ray imaging system that will ultimately be able to probe microstructures, biological single cells or even neurons. The project will exploit a powerful new electrooptical technique for obtaining chemical 'fingerprints' at the cellular level. This breakthrough will be a fundamental step towards a system for probing disease states of sin ....Breaking The Wavelength Barrier: Near-Field T-ray Imaging. Australia will benefit from the interaction between engineering, physics, and biology to develop a new T-ray imaging system that will ultimately be able to probe microstructures, biological single cells or even neurons. The project will exploit a powerful new electrooptical technique for obtaining chemical 'fingerprints' at the cellular level. This breakthrough will be a fundamental step towards a system for probing disease states of single cells and will open up new lines of scientific enquiry. Ultimately, Australia will benefit from a new technology and new diagnostic biomedical techniques. This is potentially an enabling technology for future customised medicine, where rapid biochip sensing becomes foreseeable.Read moreRead less
Biomolecular surface interactions with smart biomaterials. Current materials used for medical implants are often recognised by the body as foreign materials causing implant rejection or encapsulation. Research into the interactions between biological molecules and chemically and topographically modified materials will aid in the development of new materials and devices that optimise the body's response to the implanted material. The new materials and surfaces developed from this research will pr ....Biomolecular surface interactions with smart biomaterials. Current materials used for medical implants are often recognised by the body as foreign materials causing implant rejection or encapsulation. Research into the interactions between biological molecules and chemically and topographically modified materials will aid in the development of new materials and devices that optimise the body's response to the implanted material. The new materials and surfaces developed from this research will provide longer lasting implants and reduce the need for repeated operations. This will improve the quality of life for implant recipients and reduce health care costs.Read moreRead less
Novel coding and decoding in suspension arrays for accelerated biomolecular discovery and personalised medicine. This project will establish an advanced multiplexing technique to rapidly analyse complex biological mixtures, such as cell lysates, food samples or body fluids. It will enable the analysis of not tens, but thousands or more distinctive molecular targets in a single test. This will build the foundations for future generation bioassays, paving the way to emerging personalised medicine. ....Novel coding and decoding in suspension arrays for accelerated biomolecular discovery and personalised medicine. This project will establish an advanced multiplexing technique to rapidly analyse complex biological mixtures, such as cell lysates, food samples or body fluids. It will enable the analysis of not tens, but thousands or more distinctive molecular targets in a single test. This will build the foundations for future generation bioassays, paving the way to emerging personalised medicine. This will lead to new personal diagnostics tools for rapid genotype profiling, to better tailor therapy to the individual patient's specific characteristics. As well as the potential to improve health outcomes, the project will generate significant intellectual property and the opportunity for development of new diagnostic instrumentation in Australia.Read moreRead less
Biomolecular films on silicon substrates. Construction of hybrid carbon-silicon devices in which molecular organic molecular films are covalently linked to silicon wafers. Biomolecular nanostructures on silicon wafers can be studied using unique impedance spectroscopy instrumentation that we have developed as well as X-ray and neutron reflectometry. The system will be used to study a variety of molecular films as well as molecularly tethered lipid bilayer membranes that mimic aspects of cell mem ....Biomolecular films on silicon substrates. Construction of hybrid carbon-silicon devices in which molecular organic molecular films are covalently linked to silicon wafers. Biomolecular nanostructures on silicon wafers can be studied using unique impedance spectroscopy instrumentation that we have developed as well as X-ray and neutron reflectometry. The system will be used to study a variety of molecular films as well as molecularly tethered lipid bilayer membranes that mimic aspects of cell membranes and these will be used to investigate the effect of sterols on such membranes.Read moreRead less
TeraHertz Cell Cluster Imaging. With this program, Australia will benefit from the interaction between physics, engineering, biology and medicine to develop a new TeraHertz imaging system. The project will identify the factors that contribute to TeraHertz contrast in soft tissue cell cultures, thereby developing a non-invasive imaging system to show contrast between diseased and healthy cells. This is a fundamental step towards a system for diagnosing disease states of skin cells, for example, t ....TeraHertz Cell Cluster Imaging. With this program, Australia will benefit from the interaction between physics, engineering, biology and medicine to develop a new TeraHertz imaging system. The project will identify the factors that contribute to TeraHertz contrast in soft tissue cell cultures, thereby developing a non-invasive imaging system to show contrast between diseased and healthy cells. This is a fundamental step towards a system for diagnosing disease states of skin cells, for example, the early detection of melanoma. Ultimately, Australia will benefit from a new technology, and new diagnostic biomedical techniques, for rapid, non-invasive and reliable skin cancer diagnosis.Read moreRead less
Towards a miniaturised on-chip terahertz biosensing system. Terahertz (or T-ray) radiation is highly sensitive to minute changes in the molecular structure of many substances. Furthermore most packing materials are transparent to this new form of radiation. This implies enormous potential for T-rays in a range of applications from quality control via non-invasive contact-less chemical fingerprinting through to safety and security applications. A detailed study of the molecular vibrations that gi ....Towards a miniaturised on-chip terahertz biosensing system. Terahertz (or T-ray) radiation is highly sensitive to minute changes in the molecular structure of many substances. Furthermore most packing materials are transparent to this new form of radiation. This implies enormous potential for T-rays in a range of applications from quality control via non-invasive contact-less chemical fingerprinting through to safety and security applications. A detailed study of the molecular vibrations that give rise to these fingerprints will help chemists and biologists to learn more about the underlying molecular binding forces, impacting on wide applications for safe non-invasive sensing in the medical, security, chemical and food industries.Read moreRead less
Enabling Technologies for Motion Corrected Positron Emission Tomography (PET) of Unanaesthetized Laboratory Animals. Small animal molecular imaging is a powerful tool in biological research and drug discovery. Anaesthesia is routinely used to avoid motion distortion, but can profoundly alter the biological process studied. This research will enable quantitative imaging of neurobiological phenomena in awake laboratory animals. It will create new opportunities for Australian basic researchers to ....Enabling Technologies for Motion Corrected Positron Emission Tomography (PET) of Unanaesthetized Laboratory Animals. Small animal molecular imaging is a powerful tool in biological research and drug discovery. Anaesthesia is routinely used to avoid motion distortion, but can profoundly alter the biological process studied. This research will enable quantitative imaging of neurobiological phenomena in awake laboratory animals. It will create new opportunities for Australian basic researchers to use innovative technology with expected high economic potential, and benefit small biotech companies by facilitating pre-clinical and clinical development of new pharmaceuticals. The new motion tracking and image reconstruction technologies developed will strengthen Australia's leading position in engineering and biomedical systems development.Read moreRead less
Understanding and Modelling Insect Motion Vision. The interdisciplinary project proposed will offer a stimulating environment for research/training into computational neuroscience, an attractive area for aspiring scientists. We have already demonstrated the feasibility of transferring physiology into applications, and expect this project to deliver functional motion vision models and devices. Our proposed work will have an impact beyond the advancement of neuro-physiology as knowledge gained is ....Understanding and Modelling Insect Motion Vision. The interdisciplinary project proposed will offer a stimulating environment for research/training into computational neuroscience, an attractive area for aspiring scientists. We have already demonstrated the feasibility of transferring physiology into applications, and expect this project to deliver functional motion vision models and devices. Our proposed work will have an impact beyond the advancement of neuro-physiology as knowledge gained is applicable in a range of areas, with applications in miniature unmanned vehicles and collision avoidance detectors in defence and civilian roles. Our project could also assist in the development of artificial intelligence and as a basis for designing implantable artificial eyes.Read moreRead less