Devices that use Ion Channels. The proposed device would supply the community of researchers in Australia and internationally with new techniques to enable them to quickly and conveniently investigate properties of ion channels and to speed the screening of potential ion channel targets for pharmaceutical hits and leads. In addition, the tethered membrane technology will be developed to fill an unmet need for a quick and biologically relevant test of EMC hazards. This will enhance the science an ....Devices that use Ion Channels. The proposed device would supply the community of researchers in Australia and internationally with new techniques to enable them to quickly and conveniently investigate properties of ion channels and to speed the screening of potential ion channel targets for pharmaceutical hits and leads. In addition, the tethered membrane technology will be developed to fill an unmet need for a quick and biologically relevant test of EMC hazards. This will enhance the science and technology infrastructure within Australia, taking it into original and exciting directions, contribute to training young Australian scientists and students, as well as enhance Australia's competitive position in the field of nanobiotechnology.Read moreRead less
Development of planar patch-clamp electrophysiology to investigate liposome-based artificial nanosensor devices. This project aims to characterise the interaction of transport proteins with unsupported lipid bilayer membranes. This will provide the basis for a novel biosensor utilising mechanosensitive ion channels incorporated into an artificial lipid bilayer membrane. To support this outcome, the project will develop the planar patch-clamp electrophysiology recording techniques suitable for l ....Development of planar patch-clamp electrophysiology to investigate liposome-based artificial nanosensor devices. This project aims to characterise the interaction of transport proteins with unsupported lipid bilayer membranes. This will provide the basis for a novel biosensor utilising mechanosensitive ion channels incorporated into an artificial lipid bilayer membrane. To support this outcome, the project will develop the planar patch-clamp electrophysiology recording techniques suitable for liposomes. This provides a significant PhD training opportunity and brings an international focus to the development of planar patch-clamp electrophysiology in Australia. The project has significant commercial potential by developing both the planar patch-clamp electrophysiology techniques for liposomes and producing a novel biomimetic mechanosensitive biosensor.Read moreRead less
A neuromorphic binaural hearing sensor. A neuromorphic binaural hearing sensor will be created. The system includes two cochleae and targeted processing pathways in the auditory brainstem that aid in solving the Cocktail Party Problem: i.e. foreground-background sound separation, sound localisation, and sound recognition. The VLSI circuits will enable real-time implementation of complex auditory models. As we develop our VLSI binaural ear, we will experiment with afferent (feed forward) and ....A neuromorphic binaural hearing sensor. A neuromorphic binaural hearing sensor will be created. The system includes two cochleae and targeted processing pathways in the auditory brainstem that aid in solving the Cocktail Party Problem: i.e. foreground-background sound separation, sound localisation, and sound recognition. The VLSI circuits will enable real-time implementation of complex auditory models. As we develop our VLSI binaural ear, we will experiment with afferent (feed forward) and efferent (feed back) auditory signal processing that is similar to real auditory systems and that demonstrate efficient, effective, and low-power signal processing algorithms for binaural (two-sensor) hearing systems.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE0668448
Funder
Australian Research Council
Funding Amount
$150,000.00
Summary
See Hear! Multimodal Recording and Analysis Facility. High resolution recording and analysis will exploit the full potential of motion capture with progress towards automatic recognition of gesture and, eventually, real-time systems. Automatic tracking and recognition systems are in high demand and the interlacing of data from multiple modes is now computationally achievable. SeeHear! will be coded using techniques in multimodal fusion - tracking of bodies will be enhanced by locating and recogn ....See Hear! Multimodal Recording and Analysis Facility. High resolution recording and analysis will exploit the full potential of motion capture with progress towards automatic recognition of gesture and, eventually, real-time systems. Automatic tracking and recognition systems are in high demand and the interlacing of data from multiple modes is now computationally achievable. SeeHear! will be coded using techniques in multimodal fusion - tracking of bodies will be enhanced by locating and recognizing facial features, and a learning algorithm used to classify gesture from patterns of force and physiological response. In the future, full interactivity will be achieved by interconnecting visual and auditory data with a flow on to applications in the performing arts, rehabilitation and security.Read moreRead less
Silk Fibroin Optofluidic Chips. Unlike any other material, even any other biologically occurring material, silk is unique in being very transparent, able to be shaped on a very small scale and can keep natural chemicals like proteins and enzymes active. This project will use silk to make optical devices and sensors. Optics made from silk will have all these properties, which means that they can be used as sensors and devices in biochemistry applications that have never been possible before. Thes ....Silk Fibroin Optofluidic Chips. Unlike any other material, even any other biologically occurring material, silk is unique in being very transparent, able to be shaped on a very small scale and can keep natural chemicals like proteins and enzymes active. This project will use silk to make optical devices and sensors. Optics made from silk will have all these properties, which means that they can be used as sensors and devices in biochemistry applications that have never been possible before. These cost-effective devices will have the potential to enhance healthcare, emergency medicine and assist early medical diagnosis.Read moreRead less
The photonic immunochip: retrieving individual Enzyme-linked Immuno Sorbent Assay (ELISA) array-units using optical waveguide multicolour fluorescence. Improving the sensitivity and availability of in-vitro immuno-diagnostic tests is a critical goal towards developing real time efficient tools for the detection of infectious diseases, cancers, allergies and auto-immune diseases. The goal is to increase the sensitivity of these tests by reducing background noise that has been a feature of the com ....The photonic immunochip: retrieving individual Enzyme-linked Immuno Sorbent Assay (ELISA) array-units using optical waveguide multicolour fluorescence. Improving the sensitivity and availability of in-vitro immuno-diagnostic tests is a critical goal towards developing real time efficient tools for the detection of infectious diseases, cancers, allergies and auto-immune diseases. The goal is to increase the sensitivity of these tests by reducing background noise that has been a feature of the commonly used ELISA technology. This will be achieved by developing a novel optical integrated waveguide array supporting a large range of distributed tests, including several based on a novel multi-colour detection scheme. This massively parallel approach will underpin a new generation of low-cost, efficient diagnostic tests.Read moreRead less
Special Research Initiatives - Grant ID: SR0354583
Funder
Australian Research Council
Funding Amount
$10,000.00
Summary
Biodevice fabrication through intelligent surface modification. Achieving the reliable control of the attachment of proteins and other macromolecules to surfaces needed for sophisticated biosensors and medical diagnostics requires expertise and infrastructure from a diverse range of disciplines from the physical, chemical and biological sciences and engineering. This network will bring together researchers from a multidisciplinary pool working on problems relevant to the creation of functional s ....Biodevice fabrication through intelligent surface modification. Achieving the reliable control of the attachment of proteins and other macromolecules to surfaces needed for sophisticated biosensors and medical diagnostics requires expertise and infrastructure from a diverse range of disciplines from the physical, chemical and biological sciences and engineering. This network will bring together researchers from a multidisciplinary pool working on problems relevant to the creation of functional surfaces for applications in biodevices. The program we envisage will break down the barriers imposed by disciplinary boundaries and technical terminology to bring together the skills and infrastructure required to make rapid advances in this field.Read moreRead less
Biomolecular surface interactions with smart biomaterials. Current materials used for medical implants are often recognised by the body as foreign materials causing implant rejection or encapsulation. Research into the interactions between biological molecules and chemically and topographically modified materials will aid in the development of new materials and devices that optimise the body's response to the implanted material. The new materials and surfaces developed from this research will pr ....Biomolecular surface interactions with smart biomaterials. Current materials used for medical implants are often recognised by the body as foreign materials causing implant rejection or encapsulation. Research into the interactions between biological molecules and chemically and topographically modified materials will aid in the development of new materials and devices that optimise the body's response to the implanted material. The new materials and surfaces developed from this research will provide longer lasting implants and reduce the need for repeated operations. This will improve the quality of life for implant recipients and reduce health care costs.Read moreRead less
Novel Carbon Nanotube Composite Materials: Elucidation of key properties for device development. As the former co-director of CSIRO Nanotechnology indicated to the Sydney Morning Herald in 2003, 'Nanotechnology will lead us into a very different future.' The proposed research on nanomaterial interactions and biomolecular incorporation protocols will provide a foundation for future bioelectronic devices. Imagine healthcare of human diseases when nanocomponents enable the design of new platforms f ....Novel Carbon Nanotube Composite Materials: Elucidation of key properties for device development. As the former co-director of CSIRO Nanotechnology indicated to the Sydney Morning Herald in 2003, 'Nanotechnology will lead us into a very different future.' The proposed research on nanomaterial interactions and biomolecular incorporation protocols will provide a foundation for future bioelectronic devices. Imagine healthcare of human diseases when nanocomponents enable the design of new platforms for devices that give point-of-care diagnosis, or the impact on the semiconductor industry with the creation of flexible electronics. Educational outreach is an important aim of the project, providing effective research training for early career researchers.Read moreRead less
Novel coding and decoding in suspension arrays for accelerated biomolecular discovery and personalised medicine. This project will establish an advanced multiplexing technique to rapidly analyse complex biological mixtures, such as cell lysates, food samples or body fluids. It will enable the analysis of not tens, but thousands or more distinctive molecular targets in a single test. This will build the foundations for future generation bioassays, paving the way to emerging personalised medicine. ....Novel coding and decoding in suspension arrays for accelerated biomolecular discovery and personalised medicine. This project will establish an advanced multiplexing technique to rapidly analyse complex biological mixtures, such as cell lysates, food samples or body fluids. It will enable the analysis of not tens, but thousands or more distinctive molecular targets in a single test. This will build the foundations for future generation bioassays, paving the way to emerging personalised medicine. This will lead to new personal diagnostics tools for rapid genotype profiling, to better tailor therapy to the individual patient's specific characteristics. As well as the potential to improve health outcomes, the project will generate significant intellectual property and the opportunity for development of new diagnostic instrumentation in Australia.Read moreRead less