Discovery Early Career Researcher Award - Grant ID: DE240100236
Funder
Australian Research Council
Funding Amount
$463,583.00
Summary
Designing and fabricating artificial blood cells for global shortages. This project aims to create the first biophysically accurate artificial blood cells through fabrication of novel synthetic particles that mimic the complex layers of red blood cells. Using innovative methods from engineering and biology, this project expects to advance biofabrication techniques for biosynthetic microparticles. Expected outcomes from this project include the development of a portable, cost-effective platform t ....Designing and fabricating artificial blood cells for global shortages. This project aims to create the first biophysically accurate artificial blood cells through fabrication of novel synthetic particles that mimic the complex layers of red blood cells. Using innovative methods from engineering and biology, this project expects to advance biofabrication techniques for biosynthetic microparticles. Expected outcomes from this project include the development of a portable, cost-effective platform technology to immediately advance foundational understanding of cell membrane dynamics, interactions, and integrity. We anticipate that the new bioengineered blood product will provide significant future benefits for blood storage and transfusion, including potentially alleviating global blood shortages.Read moreRead less
Replicating the cartilage micromechanical environment. Through a novel, image-guided mechanical evaluation of cell- and tissue-level remodelling, this project aims to unlock new insights into the complex mechanical microenvironment of cartilage and directly influence new strategies in tissue engineering. The research will reveal contributions of cells and extracellular matrix components to mechanical integrity over time. It will build a world-first strain map of the cartilage microenvironment an ....Replicating the cartilage micromechanical environment. Through a novel, image-guided mechanical evaluation of cell- and tissue-level remodelling, this project aims to unlock new insights into the complex mechanical microenvironment of cartilage and directly influence new strategies in tissue engineering. The research will reveal contributions of cells and extracellular matrix components to mechanical integrity over time. It will build a world-first strain map of the cartilage microenvironment and quantification of dynamic structural remodelling that occurs, providing key targets to improve tissue engineering strategies. The project will also drive innovation in micromechanical testing technology, deliver functional solutions in mechanobiology and advance materials for biological integration.Read moreRead less