Discovery Early Career Researcher Award - Grant ID: DE160100745
Funder
Australian Research Council
Funding Amount
$347,000.00
Summary
Next generation motion-compensated brain imaging in animals and humans. The aim of this project is to develop innovative and highly practical motion tracking methods allowing human and animal subjects to move, behave and respond during imaging without at all degrading the quality of information. This should not only maximise the potential of imaging technologies to see into the brain, but also exploit a previously impossible class of experiments to probe the link between brain function and behav ....Next generation motion-compensated brain imaging in animals and humans. The aim of this project is to develop innovative and highly practical motion tracking methods allowing human and animal subjects to move, behave and respond during imaging without at all degrading the quality of information. This should not only maximise the potential of imaging technologies to see into the brain, but also exploit a previously impossible class of experiments to probe the link between brain function and behaviour.Read moreRead less
Novel technologies for motion-compensated simultaneous Magnetic Resonance Imaging (MRI) and Positron Emission Tomography (PET) imaging. The aim of this work is to develop motion tracking and motion correction techniques for an emerging hybrid imaging technology, MR-PET. The MR-PET scanner simultaneously acquires structural MR images and functional PET images. The work will provide clearer images without the effects of motion blur for both research and clinical applications.
Advanced computational algorithms for brain imaging studies of freely moving animals. Current brain imaging technology requires the animal to be unconscious. This project will remove this barrier by developing computational algorithms that measure brain function in freely moving animals. These technologies will provide brain scientists with new tools to study behaviour altering diseases, such as schizophrenia and depression.
Novel imaging technologies for continuous measurement of tracer kinetics in awake animals. The fates of biologically relevant molecules, such as proteins and antibodies, in the body are fundamentally important for understanding the mechanisms and treatment of disease. This project will enable for the first time continuous imaging of the location and time course of labelled molecules in conscious, freely moving animals.
A novel scintillating optical fibre array for cancer imaging and therapy. This project aims to realise a next-generation detector technology that delivers the first fully integrated solution to the X-ray imaging and dose measurement needs of cancer radiation therapy. It is planned that this will be achieved by optimising an experimental prototype device employing a scintillating optical fibre array to generate an optical signal that preserves a tissue-equivalent detector response. The acquired d ....A novel scintillating optical fibre array for cancer imaging and therapy. This project aims to realise a next-generation detector technology that delivers the first fully integrated solution to the X-ray imaging and dose measurement needs of cancer radiation therapy. It is planned that this will be achieved by optimising an experimental prototype device employing a scintillating optical fibre array to generate an optical signal that preserves a tissue-equivalent detector response. The acquired digital image can thus be used to simultaneously verify geometric accuracy (correct patient positioning) and dosimetric accuracy (correct dose distribution). This is not currently possible with existing X-ray detector technology and offers an improvement in treatment accuracy.Read moreRead less