Interrogating protein hydration by terahertz time-domain spectroscopy. Interrogating protein hydration by terahertz time-domain spectroscopy. This project aims to develop advanced terahertz time-domain spectroscopy (THz-TDS) techniques to understand how a protein’s interaction with excipients in solution can alter the hydration layers around them and how this affects properties such as viscosity and stability. THz-TDS can detect overlapping extended hydration layers around proteins, revealing ne ....Interrogating protein hydration by terahertz time-domain spectroscopy. Interrogating protein hydration by terahertz time-domain spectroscopy. This project aims to develop advanced terahertz time-domain spectroscopy (THz-TDS) techniques to understand how a protein’s interaction with excipients in solution can alter the hydration layers around them and how this affects properties such as viscosity and stability. THz-TDS can detect overlapping extended hydration layers around proteins, revealing new knowledge in protein-protein interactions and protein behaviour in an aqueous environment. The intended outcome is to use THz-TDS to better understand how proteins such as monoclonal antibodies interact in high concentration solutions, and in doing so make better medicines.Read moreRead less
Biological applications of terahertz technology. This project aims to develop new knowledge for exploring the interaction of terahertz (THz) radiation with different materials. THz technology is in use in diverse applications from security screening to biomedical imaging. A hurdle to the widespread adoption of the technology is the poor understanding of the basic interaction between THz radiation and molecules, proteins, cells and tissues. This project will enable development of advanced THz tec ....Biological applications of terahertz technology. This project aims to develop new knowledge for exploring the interaction of terahertz (THz) radiation with different materials. THz technology is in use in diverse applications from security screening to biomedical imaging. A hurdle to the widespread adoption of the technology is the poor understanding of the basic interaction between THz radiation and molecules, proteins, cells and tissues. This project will enable development of advanced THz technology and applications and will lead to accelerated implementation for use in chemistry, biology and, ultimately, medicalapplications such as cancer detection.Read moreRead less
Engineering the Next Generation of Terahertz Laser Imaging Systems. This project aims to develop terahertz imaging systems based on quantum cascade lasers suitable for characterisation of skin, with major implications for early skin cancer detection. Despite advances in treatment regimes, the most significant predictor of skin cancer survivability remains early detection. The project’s approach uses the semiconductor laser in the optical-feedback interferometer configuration, and is designed to ....Engineering the Next Generation of Terahertz Laser Imaging Systems. This project aims to develop terahertz imaging systems based on quantum cascade lasers suitable for characterisation of skin, with major implications for early skin cancer detection. Despite advances in treatment regimes, the most significant predictor of skin cancer survivability remains early detection. The project’s approach uses the semiconductor laser in the optical-feedback interferometer configuration, and is designed to afford significant advantages over conventional terahertz imaging platforms. The project plans to explore new semiconductor physics of a quantum cascade laser under optical feedback, engineer the semiconductor laser-based platform for medical diagnostic applications, and develop supporting numerical techniques.Read moreRead less
Discovery Early Career Researcher Award - Grant ID: DE210100453
Funder
Australian Research Council
Funding Amount
$442,408.00
Summary
Nervous tissue stimulation using Multi-Junction Silicon Photodiodes. Currently, in order to stimulate different areas in nervous tissue, brain-machine-interfaces (BMIs) usually rely on multi electrode arrays where each electrode is connected to a wire, that connects to other electronics, all of which has to be safely encapsulated, thus increasing the size of the devices and complicating the surgical procedure for implanted devices. This project aims to develop a silicon multi-junction photodiode ....Nervous tissue stimulation using Multi-Junction Silicon Photodiodes. Currently, in order to stimulate different areas in nervous tissue, brain-machine-interfaces (BMIs) usually rely on multi electrode arrays where each electrode is connected to a wire, that connects to other electronics, all of which has to be safely encapsulated, thus increasing the size of the devices and complicating the surgical procedure for implanted devices. This project aims to develop a silicon multi-junction photodiode that can provide a photovoltage high enough to efficiently excite nervous tissue. A BMI based on this approach could be much smaller and could be powered optically via thin fibres, thus in the long run enabling smaller and safer implants for restoring function in disabled people.Read moreRead less
Theoretical modelling of the interaction of THz with hydrated materials. Terahertz (THz) technology is in use in diverse applications from security screening to biomedical imaging. A critical hurdle to the widespread adoption of the technology is the poor understanding of the basic interaction between THz radiation and hydrated materials. The aim of this project is to develop new mathematical and computer models for exploring the interaction of THz radiation with different materials. These model ....Theoretical modelling of the interaction of THz with hydrated materials. Terahertz (THz) technology is in use in diverse applications from security screening to biomedical imaging. A critical hurdle to the widespread adoption of the technology is the poor understanding of the basic interaction between THz radiation and hydrated materials. The aim of this project is to develop new mathematical and computer models for exploring the interaction of THz radiation with different materials. These models aim to create a platform for the future development of THz technology and applications, and are expected to lead to accelerated implementation for use in biology and protein analysis; pharmaceutical sciences, formulations and medicine; and burn assessment and cancer detection.Read moreRead less
Model-based estimation methods for improved classification of electroencephalographic data: application to monitoring depth of anaesthesia. This project will use advanced computing methods applied to electrical brain wave recordings to track how the brain changes as a person undergoes general anaesthesia during surgery. This will lead to better anaesthesia monitoring devices and reduce the chances of people experiencing pain during surgery or IQ deficits after the anaesthesia.
Advanced Hybrid Fibres for Functional Biomedical Imaging. This project expects to develop new techniques and devices for biomedical imaging. Biomedical imaging is widely used for medical diagnosis and treatment, with different types of imaging providing different information. This project aims to develop techniques that will allow imaging using safer nonionising terahertz radiation, with better resolution than ever before. It plans to combine this with optical, visible and infrared imaging to gi ....Advanced Hybrid Fibres for Functional Biomedical Imaging. This project expects to develop new techniques and devices for biomedical imaging. Biomedical imaging is widely used for medical diagnosis and treatment, with different types of imaging providing different information. This project aims to develop techniques that will allow imaging using safer nonionising terahertz radiation, with better resolution than ever before. It plans to combine this with optical, visible and infrared imaging to give very broad spectral information. It also aims to develop probes for direct interfacing to tissue to collect and deliver electrical signals, light and fluids, and to image neural activity. The intended outcome of the project is to allow single cancer cells within tissue to be identified to allow early stage cancer detection, and to develop implantable devices for neuroscience research and pain management.Read moreRead less
Engineering the Next Generation of Terahertz Laser Imaging Systems. This project aims to develop terahertz imaging systems based on quantum cascade lasers suitable for characterisation of skin, with major implications for early skin cancer detection. Despite advances in treatment regimes, the most significant predictor of skin cancer survivability remains early detection. The project’s approach uses the semiconductor laser in the optical-feedback interferometer configuration, and is designed to ....Engineering the Next Generation of Terahertz Laser Imaging Systems. This project aims to develop terahertz imaging systems based on quantum cascade lasers suitable for characterisation of skin, with major implications for early skin cancer detection. Despite advances in treatment regimes, the most significant predictor of skin cancer survivability remains early detection. The project’s approach uses the semiconductor laser in the optical-feedback interferometer configuration, and is designed to afford significant advantages over conventional terahertz imaging platforms. The project plans to explore new semiconductor physics of a quantum cascade laser under optical feedback, engineer the semiconductor laser-based platform for medical diagnostic applications, and develop supporting numerical techniques.Read moreRead less
Individually addressable, active, multipoint electrodes for bio-potential recording and electrical impedance imaging. We will develop non-invasive devices based on biosignal and impedance monitoring. They will be highly portable and based on comfortable electrode patches that can be applied quickly in emergencies. The technology may be used to save lives and reduce disabilities by monitoring strokes and heart attacks and stimulate Australia's biomedical industry.