Bone regulation - cell interactions to disease. Many bone disorders such as osteoporosis, Paget's disease and chancer related bone diseases are directly related to disruption of communication pathways between bone cells leading to imbalances in bone remodeling. Although these disorders are common and cause considerable suffering, in most cases little is known about the mechanisms responsible for dysfunctional remodeling. Understanding the communication network between bone cells and their inter ....Bone regulation - cell interactions to disease. Many bone disorders such as osteoporosis, Paget's disease and chancer related bone diseases are directly related to disruption of communication pathways between bone cells leading to imbalances in bone remodeling. Although these disorders are common and cause considerable suffering, in most cases little is known about the mechanisms responsible for dysfunctional remodeling. Understanding the communication network between bone cells and their interaction with drugs is essential in order to develop new therapies and to effectively design novel biological compatible bone implants. This research proposal closely aligns with national research priority two, i.e., promoting and maintaining good health (ageing well, ageing productively).Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE0668435
Funder
Australian Research Council
Funding Amount
$1,300,000.00
Summary
Biomedical Engineering Sensing and Imaging Facility. The sensing and imaging facility will be the only national facility for leading engineering and medical researchers to undertake multidiscipline research into live and model biological systems. The facility will capture and combine existing strengths in these fields in Melbourne. This will provide new insights into the physiology of human, animal and plant systems and the development of preventive and curative strategies for disease.
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE0221428
Funder
Australian Research Council
Funding Amount
$530,000.00
Summary
A Transportable Optical Frequency Counter, Synthesizer and Super-Continuum Generator (OFCSSG). The generation of ultra-short light pulses of just a few femtoseconds (one thousand-trillionth of a second) in duration has enabled applications in a wide range of fields, but complexity and cost has limited availability. This project will employ recently developed optical fibre and solid-state laser technology to create a cost-effective compact transportable facility of highly coherent, ultra-broadba ....A Transportable Optical Frequency Counter, Synthesizer and Super-Continuum Generator (OFCSSG). The generation of ultra-short light pulses of just a few femtoseconds (one thousand-trillionth of a second) in duration has enabled applications in a wide range of fields, but complexity and cost has limited availability. This project will employ recently developed optical fibre and solid-state laser technology to create a cost-effective compact transportable facility of highly coherent, ultra-broadband radiation. The source will enable new research and substantially enrich existing research in optical time standards and metrology, in-vivo biological imaging, and ultrafast spectroscopy. No such facility is presently available in AustraliaRead moreRead less
Engineering cartilage homeostasis in health and disease. Arthritis is a common, painful and often debilitating disease affecting 16% of the Australian population and costing this community $11 billion every year. It is not well understood why cartilage degenerates into joint disease, nor how it may be reversed - partly due to the large number of mechanisms involved. This project aims to overcome this complexity by developing a computational model of cartilage that can integrate the various mech ....Engineering cartilage homeostasis in health and disease. Arthritis is a common, painful and often debilitating disease affecting 16% of the Australian population and costing this community $11 billion every year. It is not well understood why cartilage degenerates into joint disease, nor how it may be reversed - partly due to the large number of mechanisms involved. This project aims to overcome this complexity by developing a computational model of cartilage that can integrate the various mechanisms of cartilage degradation. New experiments will be used to validate the model and test predictions. The model developed will provide fundamental insights into what is required for the maintenance of healthy cartilage, and what happens in injury-induced degradation of cartilage.Read moreRead less