Optimising vascularisation of tissue engineering chambers for construction of robust tissues. We have produced a device that has commercial application in several fields of basic science, biotechnology and bioengineering. When its full potential is achieved, our innovative organ chamber will strengthen Australia's standing in the biotechnology field and enrich specific applications. The knowledge gained from understanding the growth of blood vessels will benefit several fields including chemical ....Optimising vascularisation of tissue engineering chambers for construction of robust tissues. We have produced a device that has commercial application in several fields of basic science, biotechnology and bioengineering. When its full potential is achieved, our innovative organ chamber will strengthen Australia's standing in the biotechnology field and enrich specific applications. The knowledge gained from understanding the growth of blood vessels will benefit several fields including chemical bioengineering, tissue engineering and repair, polymer chemistry, therapeutics in many areas (like cancer, heart disease, diabetes), hormone manufacture for agricultural, veterinary and medical purposes and cosmetics manufacture. The project will train several post-doctoral fellows and PhD students in this cutting edge field of researchRead moreRead less
Interfacial interactions with hydrogel biomaterials. The interactions between cells of the body and the surfaces of medical implants are controlled largely by the molecules that are adsorbed on the surface. The aim of this project is to evaluate the effect of modifying hydrogel biomaterials on the interactions of the molecules with the hydrogel. This, in turn, allows us to determine the factors affecting the control of the cell's response. The significance of this work is in the improved ability ....Interfacial interactions with hydrogel biomaterials. The interactions between cells of the body and the surfaces of medical implants are controlled largely by the molecules that are adsorbed on the surface. The aim of this project is to evaluate the effect of modifying hydrogel biomaterials on the interactions of the molecules with the hydrogel. This, in turn, allows us to determine the factors affecting the control of the cell's response. The significance of this work is in the improved ability to control cellular responses to implants. Such improved response will result in better health outcomes for patients, and outcomes in the form of papers and intellectual property.
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Breaking The Wavelength Barrier: Near-Field T-ray Imaging. Australia will benefit from the interaction between engineering, physics, and biology to develop a new T-ray imaging system that will ultimately be able to probe microstructures, biological single cells or even neurons. The project will exploit a powerful new electrooptical technique for obtaining chemical 'fingerprints' at the cellular level. This breakthrough will be a fundamental step towards a system for probing disease states of sin ....Breaking The Wavelength Barrier: Near-Field T-ray Imaging. Australia will benefit from the interaction between engineering, physics, and biology to develop a new T-ray imaging system that will ultimately be able to probe microstructures, biological single cells or even neurons. The project will exploit a powerful new electrooptical technique for obtaining chemical 'fingerprints' at the cellular level. This breakthrough will be a fundamental step towards a system for probing disease states of single cells and will open up new lines of scientific enquiry. Ultimately, Australia will benefit from a new technology and new diagnostic biomedical techniques. This is potentially an enabling technology for future customised medicine, where rapid biochip sensing becomes foreseeable.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE0989341
Funder
Australian Research Council
Funding Amount
$690,000.00
Summary
Advanced NanoBiomaterials Imaging Facility. The convergence of nanotechnology with biotechnology offers unprecedented opportunities to prepare nanomaterials with defined structure and function on the nanometre scale. However, the small length scales involved in nanomaterials present challenges in their characterisation, and in turn, their interaction with biological systems. The Advanced NanoBiomaterials Imaging Facility will provide state-of-the-art equipment for examining the properties of nan ....Advanced NanoBiomaterials Imaging Facility. The convergence of nanotechnology with biotechnology offers unprecedented opportunities to prepare nanomaterials with defined structure and function on the nanometre scale. However, the small length scales involved in nanomaterials present challenges in their characterisation, and in turn, their interaction with biological systems. The Advanced NanoBiomaterials Imaging Facility will provide state-of-the-art equipment for examining the properties of nanomaterials and their interaction with biosystems. The equipment will facilitate the development of new materials that are expected to underpin advances in drug delivery, diagnostics and implant devices, further strengthening Australia's strong reputation in these areas.Read moreRead less
Characterization and optimisation of Myomatrix: A novel extracellular matrix hydrogel from muscle. This project would have several sources of benefit for the community. Foremost we will have produced a product that will have a strong commercial application in several fields including basic science and bioengineering. If its full potential were achieved, the development of this innovative new hydrogel would strengthen Australia's standing in the biotechnology field and also enrich specific applic ....Characterization and optimisation of Myomatrix: A novel extracellular matrix hydrogel from muscle. This project would have several sources of benefit for the community. Foremost we will have produced a product that will have a strong commercial application in several fields including basic science and bioengineering. If its full potential were achieved, the development of this innovative new hydrogel would strengthen Australia's standing in the biotechnology field and also enrich specific applications. The knowledge gained from the characterization of this product could also be of benefit to several areas including chemical engineering, tissue engineering, tissue repair, polymer chemistry and food manufacture. The expertise generated and the possibility of collaboration, both academic and with industry would also benefit the community. Read moreRead less
Rapid Development of Biocompatible Stent Grafts for Aortic Aneurysms. Weakening of the aorta may cause an aneurysm. The present technique of its treatment involves replacing the weakened portion of the aorta with a synthetic graft. Failure of this treatment often occurs due to non-compatibility of the stent graft with natural aorta. One possible reason for this is a mismatch between elastic natural aorta and the non-elastic artificial graft. The core component of our project is the selection and ....Rapid Development of Biocompatible Stent Grafts for Aortic Aneurysms. Weakening of the aorta may cause an aneurysm. The present technique of its treatment involves replacing the weakened portion of the aorta with a synthetic graft. Failure of this treatment often occurs due to non-compatibility of the stent graft with natural aorta. One possible reason for this is a mismatch between elastic natural aorta and the non-elastic artificial graft. The core component of our project is the selection and development of a suitable biomaterial and optimization of the stent design based on hemodynamics flow analysis and its fabrication with the Fused Deposition Modelling (FDM) process.Read moreRead less
Biomolecular surface interactions with smart biomaterials. Current materials used for medical implants are often recognised by the body as foreign materials causing implant rejection or encapsulation. Research into the interactions between biological molecules and chemically and topographically modified materials will aid in the development of new materials and devices that optimise the body's response to the implanted material. The new materials and surfaces developed from this research will pr ....Biomolecular surface interactions with smart biomaterials. Current materials used for medical implants are often recognised by the body as foreign materials causing implant rejection or encapsulation. Research into the interactions between biological molecules and chemically and topographically modified materials will aid in the development of new materials and devices that optimise the body's response to the implanted material. The new materials and surfaces developed from this research will provide longer lasting implants and reduce the need for repeated operations. This will improve the quality of life for implant recipients and reduce health care costs.Read moreRead less
Biomaterial applications of synthetic elastin. The grant will develop a new collaboration between two established laboratories. The Weiss Lab (synthetic elastin; University of Sydney, Australia) will send elastin materials to the Langer Lab (interface of biotechnology and materials science; MIT, USA). Prof. Weiss will visit the Langer Lab and be trained in and participate collaboratively in the use of established MIT methodologies that will focus on applications in cardiac tissue engineering, co ....Biomaterial applications of synthetic elastin. The grant will develop a new collaboration between two established laboratories. The Weiss Lab (synthetic elastin; University of Sydney, Australia) will send elastin materials to the Langer Lab (interface of biotechnology and materials science; MIT, USA). Prof. Weiss will visit the Langer Lab and be trained in and participate collaboratively in the use of established MIT methodologies that will focus on applications in cardiac tissue engineering, controlled release of drugs and vocal fold repair. The MIT group will benefit from access to and the use of elastin materials that are developed in AustraliaRead moreRead less
Novel coding and decoding in suspension arrays for accelerated biomolecular discovery and personalised medicine. This project will establish an advanced multiplexing technique to rapidly analyse complex biological mixtures, such as cell lysates, food samples or body fluids. It will enable the analysis of not tens, but thousands or more distinctive molecular targets in a single test. This will build the foundations for future generation bioassays, paving the way to emerging personalised medicine. ....Novel coding and decoding in suspension arrays for accelerated biomolecular discovery and personalised medicine. This project will establish an advanced multiplexing technique to rapidly analyse complex biological mixtures, such as cell lysates, food samples or body fluids. It will enable the analysis of not tens, but thousands or more distinctive molecular targets in a single test. This will build the foundations for future generation bioassays, paving the way to emerging personalised medicine. This will lead to new personal diagnostics tools for rapid genotype profiling, to better tailor therapy to the individual patient's specific characteristics. As well as the potential to improve health outcomes, the project will generate significant intellectual property and the opportunity for development of new diagnostic instrumentation in Australia.Read moreRead less
Rheological and Electrical Properties of Biological Soft Tissues. Research on coupling rheological and electrical properties of biological soft tissues and their composites is fundamental to medical and sport sciences, as well as the optimal design and management of smart biomedical devices and bio-microtransducers. This project aims to develop an effective rheological and electrical constitutive law and finite element implementation together with supporting experiments to reveal the novel coupl ....Rheological and Electrical Properties of Biological Soft Tissues. Research on coupling rheological and electrical properties of biological soft tissues and their composites is fundamental to medical and sport sciences, as well as the optimal design and management of smart biomedical devices and bio-microtransducers. This project aims to develop an effective rheological and electrical constitutive law and finite element implementation together with supporting experiments to reveal the novel coupling behaviour of viscoelastic and electric fields of the innovative smart biological soft tissue. These results will provide a guideline for future research in tissue engineering and help Australian biomedical science and industries improve the modern biotransducers and smart biomicro-devices.Read moreRead less