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Discovery Early Career Researcher Award - Grant ID: DE220100757
Funder
Australian Research Council
Funding Amount
$447,654.00
Summary
Engineering Tissue Organisation Using Intelligent Additive Biomanufacturing. This project aims to organize and shape the formation of lab-grown tissue by 3D printing structures which control the behaviour of cells. This cell behaviour control will be accomplished through an interdisciplinary and multiscale pipeline of additive micromanufacturing, bioreactor engineering, cell culture, single-cell imaging, and computational modelling. In contrast with current empirical approaches, this quantitativ ....Engineering Tissue Organisation Using Intelligent Additive Biomanufacturing. This project aims to organize and shape the formation of lab-grown tissue by 3D printing structures which control the behaviour of cells. This cell behaviour control will be accomplished through an interdisciplinary and multiscale pipeline of additive micromanufacturing, bioreactor engineering, cell culture, single-cell imaging, and computational modelling. In contrast with current empirical approaches, this quantitative and predictive understanding of how to control biological processes within 3D printed environments will design and engineer more robust, customisable, scalable, and economical cell culture platforms able to optimally manufacture bespoke and complex 3D tissues for future agricultural, pharmaceutical, or medical products.Read moreRead less
Discovery Early Career Researcher Award - Grant ID: DE130100986
Funder
Australian Research Council
Funding Amount
$375,000.00
Summary
An innovative platform using non-coding ribonucleic acids (RNAs) to control stem cell differentiation outcomes. It is difficult to control the tissue type that stem cells will form when combined with biomaterials, as the outcome is influenced by the 'stiffness' of the surface to which the stem cells attach. This project will determine how non-coding ribonucleic acids (RNAs) control stem cell behaviours and use this information to direct stem cell differentiation outcomes.
Discovery Early Career Researcher Award - Grant ID: DE160100745
Funder
Australian Research Council
Funding Amount
$347,000.00
Summary
Next generation motion-compensated brain imaging in animals and humans. The aim of this project is to develop innovative and highly practical motion tracking methods allowing human and animal subjects to move, behave and respond during imaging without at all degrading the quality of information. This should not only maximise the potential of imaging technologies to see into the brain, but also exploit a previously impossible class of experiments to probe the link between brain function and behav ....Next generation motion-compensated brain imaging in animals and humans. The aim of this project is to develop innovative and highly practical motion tracking methods allowing human and animal subjects to move, behave and respond during imaging without at all degrading the quality of information. This should not only maximise the potential of imaging technologies to see into the brain, but also exploit a previously impossible class of experiments to probe the link between brain function and behaviour.Read moreRead less
Discovery Early Career Researcher Award - Grant ID: DE120101302
Funder
Australian Research Council
Funding Amount
$375,000.00
Summary
Lab-on-a-chip platforms for hemodynamics research: new approaches for the study of blood diseases. This project will use advanced microfluidic technologies to study how and why blood clotting occurs. New devices will be created that can precisely analyse the ability of blood to form clots and these will become powerful tools for the diagnosis of blood disorders and the research and validation of drugs for the treatment of these disorders.
Discovery Early Career Researcher Award - Grant ID: DE140100229
Funder
Australian Research Council
Funding Amount
$293,920.00
Summary
Ultra-low field magnetic resonance imaging with an array of localised magnetic field sensor . The aim of this project is to design and construct a multifunctional ultra-low magnetic field (ULF) magnetic resonance imaging (MRI) and nuclear magnetic resonance (NMR) instrument equipped with novel magnetic field sensors. This project is significant because it will deliver an instrument with enhanced sensitivity which is capable of obtaining non-invasive three-dimensional structural imaging of sample ....Ultra-low field magnetic resonance imaging with an array of localised magnetic field sensor . The aim of this project is to design and construct a multifunctional ultra-low magnetic field (ULF) magnetic resonance imaging (MRI) and nuclear magnetic resonance (NMR) instrument equipped with novel magnetic field sensors. This project is significant because it will deliver an instrument with enhanced sensitivity which is capable of obtaining non-invasive three-dimensional structural imaging of samples. This instrument will enable operation of highly sensitive ULF-MRI or ULF-NMR with regenerative energy sources and be a low-cost solution; reducing operation and maintenance costs as well as power consumption.Read moreRead less
Discovery Early Career Researcher Award - Grant ID: DE140101553
Funder
Australian Research Council
Funding Amount
$395,220.00
Summary
A flexible virus-like particle delivery platform for next-generation vaccines. Murine polyomavirus (MPyV) capsid proteins self-assemble into spherical protein shells approximately 45 nm in diameter. Such virus-like particles (VLPs) are of considerable interest as bionanotechnological tools. The unique flexibility provided by MPyV VLPs will be exploited by exploring the ability of the interior cavity to retain bioactive cargos while engineering novel functionality on the exterior surface by 'mix- ....A flexible virus-like particle delivery platform for next-generation vaccines. Murine polyomavirus (MPyV) capsid proteins self-assemble into spherical protein shells approximately 45 nm in diameter. Such virus-like particles (VLPs) are of considerable interest as bionanotechnological tools. The unique flexibility provided by MPyV VLPs will be exploited by exploring the ability of the interior cavity to retain bioactive cargos while engineering novel functionality on the exterior surface by 'mix-and-match' assembly of VLPs from modified components. As a proof of concept for next-generation vaccines that stimulate much needed, broadly protective responses against infectious diseases, model antigens will be delivered to specific immune cells using this nano-container.Read moreRead less
Discovery Early Career Researcher Award - Grant ID: DE220100302
Funder
Australian Research Council
Funding Amount
$461,300.00
Summary
A long-lasting interface for communicating with the brain. This project aims to address the most urgent challenges in developing the next generation of implantable devices for communicating with the brain. Using a new type of carbon-based electrode, along with light therapy, this project expects to build innovative technologies that can greatly enhance the functionality and longevity of these devices. Expected outcomes include a novel tool that can be implemented to obtain detailed insights into ....A long-lasting interface for communicating with the brain. This project aims to address the most urgent challenges in developing the next generation of implantable devices for communicating with the brain. Using a new type of carbon-based electrode, along with light therapy, this project expects to build innovative technologies that can greatly enhance the functionality and longevity of these devices. Expected outcomes include a novel tool that can be implemented to obtain detailed insights into neural circuits, advancing our understanding of neural function and pioneering feedback and closed-loop neuroscience. This project should provide significant benefits in neuroscience research and the neural interface industry, both of which have the ultimate goal to unlock the mysteries of the brain.Read moreRead less
Discovery Early Career Researcher Award - Grant ID: DE160100843
Funder
Australian Research Council
Funding Amount
$330,000.00
Summary
Regulating gene delivery with light. This project seeks to deliver the capacity to remotely deliver molecules into specific cells without the need for invasive or viral procedures. Individual genetic predisposition to disease forms a key part of personalised medicine that requires the accurate delivery of drugs or genes. This project aims to develop a new multimodality microscopy that can investigate and optimise light delivery of macromolecules into living cells at high specificity and across a ....Regulating gene delivery with light. This project seeks to deliver the capacity to remotely deliver molecules into specific cells without the need for invasive or viral procedures. Individual genetic predisposition to disease forms a key part of personalised medicine that requires the accurate delivery of drugs or genes. This project aims to develop a new multimodality microscopy that can investigate and optimise light delivery of macromolecules into living cells at high specificity and across a multitude of cells. The expected outcome of this project is a new form of in vivo molecular delivery system using light.Read moreRead less
Discovery Early Career Researcher Award - Grant ID: DE140101530
Funder
Australian Research Council
Funding Amount
$372,744.00
Summary
Synchrotron-based modelling of the deformation and fracture mechanism in normal and osteoporotic femurs under multiaxial loading cycles. The femur is a light-weight structure designed to best perform in life. However, the complex tissue architecture, microstructural organisation and its complex loading regimens make it difficult to understand how the femur can deform and fracture. This project studies femoral fractures by modelling the proximal femur with a micrometric level of detail. Synchrotr ....Synchrotron-based modelling of the deformation and fracture mechanism in normal and osteoporotic femurs under multiaxial loading cycles. The femur is a light-weight structure designed to best perform in life. However, the complex tissue architecture, microstructural organisation and its complex loading regimens make it difficult to understand how the femur can deform and fracture. This project studies femoral fractures by modelling the proximal femur with a micrometric level of detail. Synchrotron femur images are taken in loaded and unloaded conditions. Cortical strain and fracture are measured, replicating possible multiaxial loads. Micro finite-element models will be used to study the contribution that the bone tissue architecture, tissue structure and activity types make to the fracture. The resulting knowledge will have future orthopaedic applications.Read moreRead less
Discovery Early Career Researcher Award - Grant ID: DE130100922
Funder
Australian Research Council
Funding Amount
$375,000.00
Summary
Diamond cybernetics: nanocrystalline diamond for interfacing bionic devices with the human nervous system. Bionic devices will soon be used to treat disorders such as epilepsy, Parkinson's and depression. We will use diamond to create high resolution, permanent electrical connections between devices and the human nervous system. These diamond connections will preserve nerve health and make bionic devices more effective and able to last a lifetime.