Synthesis of stimuli-responsive star polymers for controlled drug delivery. The project aims to prepare novel star polymers suitable for drug delivery via controlled radical polymerization techniques. Such star polymers can be employed to release drugs within the human body in a controlled manner over time and are thus able to target specific sites, i.e. a tumor. The release characterisitics are be influenced by the structure and the size of the star polymer, which can easily be altered via cont ....Synthesis of stimuli-responsive star polymers for controlled drug delivery. The project aims to prepare novel star polymers suitable for drug delivery via controlled radical polymerization techniques. Such star polymers can be employed to release drugs within the human body in a controlled manner over time and are thus able to target specific sites, i.e. a tumor. The release characterisitics are be influenced by the structure and the size of the star polymer, which can easily be altered via controlled radical polymerization techniques. These novel stars are expected to improve the release kinetics of the drug comparing to similar structured micelles due to their higher stability upon injection.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE0775592
Funder
Australian Research Council
Funding Amount
$388,000.00
Summary
A High Resolution Analytical Scanning Electron Microscope for South-East Queensland. Scanning electron microscopy is the major visualization tool for a diverse range of research disciplines. This new generation of instrument will be able to image features close to atomic resolution and obtain quantitative analytical information from regions only a few atoms across. Because of the nature of the way the electron beam is produced, the new instrument will be able to examine particularly sensitive ma ....A High Resolution Analytical Scanning Electron Microscope for South-East Queensland. Scanning electron microscopy is the major visualization tool for a diverse range of research disciplines. This new generation of instrument will be able to image features close to atomic resolution and obtain quantitative analytical information from regions only a few atoms across. Because of the nature of the way the electron beam is produced, the new instrument will be able to examine particularly sensitive materials, such as soft bio-materials, without any loss in resolving power. This machine will be unique in Australia and be available to researchers from diverse fields of study working towards building and transforming Australian Industries and underpinning scientific discovery in nanotechnology, materials science and bioengineering.Read moreRead less
Novel manufacturing methods for tissue engineering scaffolds. Novel methods of manufacturing biodegradable polymer scaffolds around which new tissue can be grown within the human body will be developed. Surfactant - polymer assemblies will be used to produce highly porous scaffolds of tunable pore size and connectivity, shape and strength. The results will create a new avenue for systematic investigations into the effects of scaffold structure on tissue growth. This research will lead to the dev ....Novel manufacturing methods for tissue engineering scaffolds. Novel methods of manufacturing biodegradable polymer scaffolds around which new tissue can be grown within the human body will be developed. Surfactant - polymer assemblies will be used to produce highly porous scaffolds of tunable pore size and connectivity, shape and strength. The results will create a new avenue for systematic investigations into the effects of scaffold structure on tissue growth. This research will lead to the development of reliable, well-controlled manufacturing techniques for tissue engineering scaffolds, revolutionising current scaffold manufacturing practices. It will enhance existing collaborations between the University of Melbourne and the Bernard O'Brien Institute of Microsurgery.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE0561247
Funder
Australian Research Council
Funding Amount
$168,810.00
Summary
An advanced scanning probe microscopy facility. The development of advanced materials with high performance and functionality for applications such as medical implants, solar energy, drug delivery and gas separation is facilitated by the availability of sophisticated characterisation methods. Scanning probe microscopy (SPM) has become an essential tool in materials science, biomaterials development, nanotechnology and biology. The aim of this proposal is to provide a high performance SPM system ....An advanced scanning probe microscopy facility. The development of advanced materials with high performance and functionality for applications such as medical implants, solar energy, drug delivery and gas separation is facilitated by the availability of sophisticated characterisation methods. Scanning probe microscopy (SPM) has become an essential tool in materials science, biomaterials development, nanotechnology and biology. The aim of this proposal is to provide a high performance SPM system as an enabling technology to advance the excellent research being performed at the collaborating universities.Read moreRead less
Biologically-Inspired Recognition and Processing in Colloidal Systems. The proposed research will enhance the understanding of forces and adsorption in biologically-inspired synthetic systems, and thereby create new strategies for improving selective adsorption, stabilization, coagulation, and separation. The expected outcomes are: increased understanding of chiral interactions at surfaces, a technique for rapid measurement of surface selectivity, new and better agents for chiral separation, a ....Biologically-Inspired Recognition and Processing in Colloidal Systems. The proposed research will enhance the understanding of forces and adsorption in biologically-inspired synthetic systems, and thereby create new strategies for improving selective adsorption, stabilization, coagulation, and separation. The expected outcomes are: increased understanding of chiral interactions at surfaces, a technique for rapid measurement of surface selectivity, new and better agents for chiral separation, a reduction in the use of organic pollutants, new methods for colloidal processing that will enable the preparation of new materials, and new surface coatings for increasing the useful life-time of medical implants.Read moreRead less
Novel biomaterials from improved understanding of the structure of starch. The microstructure of starch, comprising two polymers of glucose: amylose (linear, except for a few long branches) and amylopectin (with a complex tree-like architecture), is described by a high-dimensional function. This project examines simplified measures of the full microstructure, such as the distribution of lengths if all links were cut, and also properties which depend on the full architecture, such as viscoelastic ....Novel biomaterials from improved understanding of the structure of starch. The microstructure of starch, comprising two polymers of glucose: amylose (linear, except for a few long branches) and amylopectin (with a complex tree-like architecture), is described by a high-dimensional function. This project examines simplified measures of the full microstructure, such as the distribution of lengths if all links were cut, and also properties which depend on the full architecture, such as viscoelastic response and adhesion. Theory, simulation and neural networks will be used to guide experiments to elucidate which partial structure measures control which property. Outcomes will include means of helping biotechnology create improved biomaterials, and plant breeders to improve food quality.Read moreRead less
Calcification of acrylic hydrogels in abiotic media: mechanism and control. Poly(2-hydroxyethyl methacrylate (PHEMA) and other acrylic hydrogels are extensively used as biomaterials, yet conclusive evidence exists that they have a propensity to calcify following implantation. This process has undesirable consequences on the functionality of various prostheses. Based on preliminary observations that PHEMA can promote the deposition of calcium minerals from media devoid of biological factors, whic ....Calcification of acrylic hydrogels in abiotic media: mechanism and control. Poly(2-hydroxyethyl methacrylate (PHEMA) and other acrylic hydrogels are extensively used as biomaterials, yet conclusive evidence exists that they have a propensity to calcify following implantation. This process has undesirable consequences on the functionality of various prostheses. Based on preliminary observations that PHEMA can promote the deposition of calcium minerals from media devoid of biological factors, which appears thus to be an inherent property of the polymer, the project aims at formulating new hypotheses to explain this phenomenon, and to confirm them experimentally. The "chelation" hypothesis will be validated by modifying the structure of polymers, and the "spontaneous precipitation" hypothesis by assessing the effect of solutes on the equilibrium water content of polymers. NMR and FTIR spectrometric techniques will be used to gain further insight into the mechanism of calcification. Methods to prevent the calcification will potentially result from these experiments, however, anticalcification agents will also be incorporated into hydrogels and their effect evaluated in calcification assays.Read moreRead less