Discovery Early Career Researcher Award - Grant ID: DE220100055
Funder
Australian Research Council
Funding Amount
$451,415.00
Summary
Impact of seaweed polyphenols on gut health: Gut microbiome modulation. This project aims to understand the true impact of seaweed polyphenols on the gut microbiome and develop methods to improve their bioavailability, bioaccessibility and bioactivities in the gut. The project's use of cutting-edge analytical tools helps to investigate the movement and absorption of phenolic compounds across the gut. This project expects to explore new knowledge in the area of marine-based functional foods and t ....Impact of seaweed polyphenols on gut health: Gut microbiome modulation. This project aims to understand the true impact of seaweed polyphenols on the gut microbiome and develop methods to improve their bioavailability, bioaccessibility and bioactivities in the gut. The project's use of cutting-edge analytical tools helps to investigate the movement and absorption of phenolic compounds across the gut. This project expects to explore new knowledge in the area of marine-based functional foods and their health benefits using an innovative interdisciplinary approach. The success of this project will ultimately provide a new pathway for the development of functional foods that will help to improve the health status of Australians by consuming healthy food ingredients.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE210100148
Funder
Australian Research Council
Funding Amount
$1,350,000.00
Summary
Advanced Nuclear Magnetic Resonance Technologies for Southeast Queensland. This project aims to establish an advanced Nuclear Magnetic Resonance capability and capacity at two of Queenslands' leading research intensive universities. The project expects to enhance the scope and productivity of hundreds of research projects spanning natural products, synthetic, medicinal, materials and environmental science. Expected outcomes include smarter science, more productive collaborations and superior res ....Advanced Nuclear Magnetic Resonance Technologies for Southeast Queensland. This project aims to establish an advanced Nuclear Magnetic Resonance capability and capacity at two of Queenslands' leading research intensive universities. The project expects to enhance the scope and productivity of hundreds of research projects spanning natural products, synthetic, medicinal, materials and environmental science. Expected outcomes include smarter science, more productive collaborations and superior research training, leading to innovative solutions to challenging problems that confront science and society. This investment should provide significant benefits in the form of new knowledge across multiple disciplines, informing the design of future medicines, agrochemicals, materials and other products.
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Opening Up Access to L-Sugars through a Synergy of Experiment and Theory. This project aims to address a major bottleneck in the science of carbohydrates by developing the first broad-scope synthetic routes to L-sugars. L-sugars are critical components of many biologically and commercially significant molecules, but knowledge of their functional roles is impeded by the fact that most L-sugars are expensive or difficult to make. This project expects to develop expeditious routes to L-sugars via a ....Opening Up Access to L-Sugars through a Synergy of Experiment and Theory. This project aims to address a major bottleneck in the science of carbohydrates by developing the first broad-scope synthetic routes to L-sugars. L-sugars are critical components of many biologically and commercially significant molecules, but knowledge of their functional roles is impeded by the fact that most L-sugars are expensive or difficult to make. This project expects to develop expeditious routes to L-sugars via an innovative combination of synthetic and theoretical chemistry. Expected outcomes include a markedly increased capacity to access pure samples of L-sugar-based biomolecules, as needed for studying their biological functions. Significant benefits in the development of vaccines, diagnostics and biomaterials are anticipated.Read moreRead less
Developing a multicomponent platform for targeted gene delivery. Gene delivery systems are important tools in biological research and offer many exciting future prospects. Delivering gene material is very difficult in practice: rapid deterioration, poor cell uptake, and reaching the right tissue and cell types are major obstacles. Ways to overcome each barrier individually have been suggested in existing research but these components have not yet been combined in a single solution, which this pr ....Developing a multicomponent platform for targeted gene delivery. Gene delivery systems are important tools in biological research and offer many exciting future prospects. Delivering gene material is very difficult in practice: rapid deterioration, poor cell uptake, and reaching the right tissue and cell types are major obstacles. Ways to overcome each barrier individually have been suggested in existing research but these components have not yet been combined in a single solution, which this project will tackle. This proposal aims to create a technology to stabilise and deliver active gene material to target cells. The gene delivery tool developed in this project will advance biological research greatly with many potential future applications.Read moreRead less
Industrial Transformation Training Centres - Grant ID: IC210100040
Funder
Australian Research Council
Funding Amount
$4,997,903.00
Summary
ARC Training Centre for Facilitated Advancement of Australia's Bioactives (FAAB). The Centre for Facilitated Advancement of Australia's Bioactives (FAAB) will transform the rapidly growing bioactive ingredients sector. It will apply advanced analytical methods to molecular characterisation of bioactive products derived from foods, food-waste, and cell-based biotechnologies. FAAB will determine modes of action for bioactives with potential lifestyle and nutritional benefits allowing for evidence- ....ARC Training Centre for Facilitated Advancement of Australia's Bioactives (FAAB). The Centre for Facilitated Advancement of Australia's Bioactives (FAAB) will transform the rapidly growing bioactive ingredients sector. It will apply advanced analytical methods to molecular characterisation of bioactive products derived from foods, food-waste, and cell-based biotechnologies. FAAB will determine modes of action for bioactives with potential lifestyle and nutritional benefits allowing for evidence-informed decision-making, and regulatory framework development. FAAB graduates will lead and deliver future national self-reliance to the Australian bioactives sector, increasing diversification and international competitiveness and development of regulation in a growing market. Read moreRead less
Barriers and pathways to development of Indigenous traditional medicines. This project aims to explore how Australian regulatory systems can better support Aboriginal and Torres Strait Islander Traditional Knowledge (TK) holders to commercialise their traditional medicines. Focusing on the mudjala plant and working with the Kimberley’s Nyikina people, the project should generate new anthropological methods for documenting TK related to traditional medicine, new models for regulating traditional ....Barriers and pathways to development of Indigenous traditional medicines. This project aims to explore how Australian regulatory systems can better support Aboriginal and Torres Strait Islander Traditional Knowledge (TK) holders to commercialise their traditional medicines. Focusing on the mudjala plant and working with the Kimberley’s Nyikina people, the project should generate new anthropological methods for documenting TK related to traditional medicine, new models for regulating traditional medicinal products, and pharmacological insights into traditional methods of activating the plant. Additional expected outcomes include unlocking the significant, untapped potential for Indigenous Australians to benefit from the development of traditional medicine products regulated by the Therapeutic Goods Administration.Read moreRead less
Unlocking the genetic and biochemical potential of kangaroo paws. Using cutting-edge gene technology and an interdisciplinary approach, this project aims to uncover the genes responsible for flower colour in the iconic kangaroo paws of Western Australia, and identify the compounds that produce the colours. The project expects to produce the first entire kangaroo paw genome and identify unique genetic variants and biochemicals underlying colour differences. This new knowledge should help horticul ....Unlocking the genetic and biochemical potential of kangaroo paws. Using cutting-edge gene technology and an interdisciplinary approach, this project aims to uncover the genes responsible for flower colour in the iconic kangaroo paws of Western Australia, and identify the compounds that produce the colours. The project expects to produce the first entire kangaroo paw genome and identify unique genetic variants and biochemicals underlying colour differences. This new knowledge should help horticultural programs to more easily breed varieties with desirable and highly marketable new colours, and could assist in conserving these amazing Australian plants.Read moreRead less
Conotoxin diversification and evolution of venom peptides in cone snails. The marine snails of the genus Conus have evolved one of the most complex venoms that has emerged as a rich source of novel bioactive peptides. However, < 0.1% of their true potential has been characterised to-date. Using advanced genomic, proteomic, structural and pharmacological approaches pioneered in our laboratory, this study will decipher how conotoxin diversification from ancestral worm hunters facilitated the shift ....Conotoxin diversification and evolution of venom peptides in cone snails. The marine snails of the genus Conus have evolved one of the most complex venoms that has emerged as a rich source of novel bioactive peptides. However, < 0.1% of their true potential has been characterised to-date. Using advanced genomic, proteomic, structural and pharmacological approaches pioneered in our laboratory, this study will decipher how conotoxin diversification from ancestral worm hunters facilitated the shift in diet to modern fish and mollusc hunting species by determining the evolutionary trajectories of positively selected conotoxins. Investigation of the structure and function of these highly optimised venom peptides will provide new research tools and potential leads to new pharmaceuticals and agrochemicals.Read moreRead less
Chemical probes to dissect the cell cycle of globally important parasites . This project aims to develop new reagents, called chemical probes, to visualise key biological events in globally important pathogens. We will use innovative chemistry to modify the building blocks of DNA and provide researchers with essential tools to 'see' DNA synthesis in order to study growth and replication of pathogens in combination with microscopy. This project expects to support a major technical advance that wi ....Chemical probes to dissect the cell cycle of globally important parasites . This project aims to develop new reagents, called chemical probes, to visualise key biological events in globally important pathogens. We will use innovative chemistry to modify the building blocks of DNA and provide researchers with essential tools to 'see' DNA synthesis in order to study growth and replication of pathogens in combination with microscopy. This project expects to support a major technical advance that will address important gaps in our understanding of many pathogens (e.g. those that cause malaria and tuberculosis), at both the cellular and molecular levels. This should provide significant benefits by enabling researchers worldwide to identify new intervention opportunities that target unique aspects of pathogen biology.Read moreRead less