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Advancing hybrid imaging with magnetic resonance imaging and positron emission tomography (MRI-PET). This project aims to increase the utility, accessibility, cost-effectiveness and accuracy of magnetic resonance imaging and positron emission tomography (MRI-PET) hybrid imaging technology for brain tumour imaging. This project will develop new contrast agents, better ways of measuring their uptake including a new high sensitivity MRI-PET head coil and methods for predicting tumour progression us ....Advancing hybrid imaging with magnetic resonance imaging and positron emission tomography (MRI-PET). This project aims to increase the utility, accessibility, cost-effectiveness and accuracy of magnetic resonance imaging and positron emission tomography (MRI-PET) hybrid imaging technology for brain tumour imaging. This project will develop new contrast agents, better ways of measuring their uptake including a new high sensitivity MRI-PET head coil and methods for predicting tumour progression using imaging information.Read moreRead less
Unlocking the genetic and biochemical potential of kangaroo paws. Using cutting-edge gene technology and an interdisciplinary approach, this project aims to uncover the genes responsible for flower colour in the iconic kangaroo paws of Western Australia, and identify the compounds that produce the colours. The project expects to produce the first entire kangaroo paw genome and identify unique genetic variants and biochemicals underlying colour differences. This new knowledge should help horticul ....Unlocking the genetic and biochemical potential of kangaroo paws. Using cutting-edge gene technology and an interdisciplinary approach, this project aims to uncover the genes responsible for flower colour in the iconic kangaroo paws of Western Australia, and identify the compounds that produce the colours. The project expects to produce the first entire kangaroo paw genome and identify unique genetic variants and biochemicals underlying colour differences. This new knowledge should help horticultural programs to more easily breed varieties with desirable and highly marketable new colours, and could assist in conserving these amazing Australian plants.Read moreRead less
Novel antimicrobial surface coatings for biomedical applications. There are currently no effective biomaterial coatings to reduce device related infections. Such materials are needed to address the high rates of infection that can occur. The melimine technology proposed here has the potential to significantly reduce rates of infection, reduce health care costs and advantage the Australian biomaterials industry.
Discovery of bioactive natural substances from uncultured bacteria and their production using photosynthetic reactor technology. The range and rate of natural product discovery is the limiting factor in developing new therapies for cancer and infectious disease. This research will enable the discovery of new drugs, coupled to their production in a photosynthetic expression system. This represents a truly “green” and sustainable technology for the pharmaceutical industry.
Characterisation of a new class of antimicrobial agent for multidrug-resistant infections. New drugs are required to combat the development of antibiotic resistance. This project will conduct further tests on a new compound that has shown initial activity against resistant superbugs by understanding how it works against bacteria and varying the chemical structure to improve effectiveness.
A novel drug class for the effective treatment of Giardia infections. Companion animals play a pivotal role in the lifestyle of the average Australian family. The 9 million cats and dogs, residing in >65% of our households, have provided significant health and well-being benefits to owners, especially during COVID. Ensuring pet health is a primary obligation of pet ownership. Giardia infections (Giardia duodenalis, with 94% of infections in dogs identified as Assemblage A) is the most prevalent ....A novel drug class for the effective treatment of Giardia infections. Companion animals play a pivotal role in the lifestyle of the average Australian family. The 9 million cats and dogs, residing in >65% of our households, have provided significant health and well-being benefits to owners, especially during COVID. Ensuring pet health is a primary obligation of pet ownership. Giardia infections (Giardia duodenalis, with 94% of infections in dogs identified as Assemblage A) is the most prevalent enteric parasite identified globally in dogs. Infection rates can be as high as 75% in puppies. Current treatments are failing due to poor efficacy, resistance and poor adherence to treatment schedules. We have identified a novel, extremely rapid acting series of compounds capable of single shot eradication of Giardia.Read moreRead less
Heterologous expression of cyanobacterial compounds of analytical and therapeutic value. The project team has previously discovered the genetic basis for toxin production in cyanobacteria and algae. This project aims to define the biochemical pathways of the unique biosynthetic enzymes involved in alkaloid and cyclic peptide toxin production in these microorganisms. Via the development of large-gene cloning strategies, the toxins will be produced in a stable, sustainable and secure fermentation ....Heterologous expression of cyanobacterial compounds of analytical and therapeutic value. The project team has previously discovered the genetic basis for toxin production in cyanobacteria and algae. This project aims to define the biochemical pathways of the unique biosynthetic enzymes involved in alkaloid and cyclic peptide toxin production in these microorganisms. Via the development of large-gene cloning strategies, the toxins will be produced in a stable, sustainable and secure fermentation system. These compounds will be critical for standardising toxin detection methods in water supplies globally and for assessing their bioactivities in humans and other animals. Research students and the industry partner will also be trained to apply these novel biotechnologies for the production of other drug-like molecules.Read moreRead less
Unleashing the Hidden Chemical Diversity in Australian Fungi. This project aims to exploit an exclusive genomic resource consisting of >150 unique Australian filamentous fungi that has been built in a university-industry collaboration for genomic-guided biodiscovery. The genome sequence of these fungi revealed extensive hidden genetic instructions for production of novel biologically active molecules. The project will apply cutting-edge synthetic biology and chemical tools to tap into the hidden ....Unleashing the Hidden Chemical Diversity in Australian Fungi. This project aims to exploit an exclusive genomic resource consisting of >150 unique Australian filamentous fungi that has been built in a university-industry collaboration for genomic-guided biodiscovery. The genome sequence of these fungi revealed extensive hidden genetic instructions for production of novel biologically active molecules. The project will apply cutting-edge synthetic biology and chemical tools to tap into the hidden genomic potential of these Australian fungi. Expected outcomes of this project include new fine chemicals and lead molecules with desirable bioactivies. This will provide significant benefits to Australia's economy through the discovery of new pharmaceuticals, veterinary products and agrichemicals.Read moreRead less
Open source drug discovery for malaria. This project aims to discover a new drug for the treatment of malaria. In stark contrast to the traditional process of drug discovery, and to accelerate the project's progress, the research will be open source, meaning that anyone can participate and there will be no patents.
Synthesis and Structure-Function Studies of the Glycoprotein Adiponectin. This project aims to understand the role of carbohydrate modifications on the structure and function of the fat cell-derived hormone adiponectin, which has shown protective effects against obesity, type 2 diabetes and cardiovascular disease. Advancing knowledge of the molecular mechanisms that regulate fat is crucial to unravelling the processes involved in the development of these diseases. The project plans to use novel ....Synthesis and Structure-Function Studies of the Glycoprotein Adiponectin. This project aims to understand the role of carbohydrate modifications on the structure and function of the fat cell-derived hormone adiponectin, which has shown protective effects against obesity, type 2 diabetes and cardiovascular disease. Advancing knowledge of the molecular mechanisms that regulate fat is crucial to unravelling the processes involved in the development of these diseases. The project plans to use novel synthetic technologies to access a library of adiponectins with defined patterns of carbohydrates attached to the peptide backbone, thus potentially enabling detailed dissection of the role of these modifications on structure, cell signalling and insulin sensitising activities.Read moreRead less