Neural circuit control of effort under stress . This Project aims to investigate how the ‘decision’ to persist in exerting effort to obtain a reward is encoded in the the brain and affected by stress. This work will generate new knowledge on the neural mechanisms through which stress modifies neural activity to control decision making processes underpinning adaptive behaviours essential for survival. The expected outcomes of this work include enhanced capacity at the interface of behavioural a ....Neural circuit control of effort under stress . This Project aims to investigate how the ‘decision’ to persist in exerting effort to obtain a reward is encoded in the the brain and affected by stress. This work will generate new knowledge on the neural mechanisms through which stress modifies neural activity to control decision making processes underpinning adaptive behaviours essential for survival. The expected outcomes of this work include enhanced capacity at the interface of behavioural and computational neuroscience, that will in turn provide significant benefits through greater insight into brain functions essential for survival, with long ranging implications for performance optimisation and brain-inspired computing. Read moreRead less
Discovery Early Career Researcher Award - Grant ID: DE240100950
Funder
Australian Research Council
Funding Amount
$459,051.00
Summary
Identifying hypothalamic circuits that integrate stress and metabolism. This project aims to investigate how the brain integrates threat during hunger. Using cutting-edge technology to manipulate and record neural activity this project will elucidate the brain circuits that integrate threat and appetite to minimize stress exposure during foraging. This will expand our knowledge on how the brain perceives and responds to hunger and may provide relevant information for a large number of basic biol ....Identifying hypothalamic circuits that integrate stress and metabolism. This project aims to investigate how the brain integrates threat during hunger. Using cutting-edge technology to manipulate and record neural activity this project will elucidate the brain circuits that integrate threat and appetite to minimize stress exposure during foraging. This will expand our knowledge on how the brain perceives and responds to hunger and may provide relevant information for a large number of basic biological processes controlling the brain. Expected outcomes of this project will contribute to a better understanding of the circuitry controlling more complex decisions from food selection through to social interactions. This should provide significant benefits for Australia’s competitiveness within neuroscience research.Read moreRead less
Discovery Early Career Researcher Award - Grant ID: DE230100380
Funder
Australian Research Council
Funding Amount
$447,683.00
Summary
The dynamics of object representations in the human brain. The human brain's ability to effortlessly recognise and categorise objects enables effective behavioural responses in complex everyday environments. Despite the apparent efficiency of this process, it is still unknown how the brain solves object recognition. This project capitalises on cutting-edge advances in artificial intelligence and neuroscience to resolve the spatiotemporal dynamics of object processing in the human brain. The outc ....The dynamics of object representations in the human brain. The human brain's ability to effortlessly recognise and categorise objects enables effective behavioural responses in complex everyday environments. Despite the apparent efficiency of this process, it is still unknown how the brain solves object recognition. This project capitalises on cutting-edge advances in artificial intelligence and neuroscience to resolve the spatiotemporal dynamics of object processing in the human brain. The outcomes will be a step change in our understanding of the nature and development of the multi-dimensional space underpinning neural object processing. This will ultimately facilitate the diagnosis and treatment of brain disorders across the lifespan and accelerate the development of intelligent machines.Read moreRead less
Midbrain hunger signalling modifies decision making under conflict. Decision-making is one of the most important and fundamental biological processes executed by the mammalian brain. Environmental threats and physiological pressures, such as hunger, can influence decision-making processes skewing the risk/reward ratio, yet how the brain integrates these conflicting goals to determine action selection is unknown. This project aims to investigate brain chemistry and circuitry controlling decision ....Midbrain hunger signalling modifies decision making under conflict. Decision-making is one of the most important and fundamental biological processes executed by the mammalian brain. Environmental threats and physiological pressures, such as hunger, can influence decision-making processes skewing the risk/reward ratio, yet how the brain integrates these conflicting goals to determine action selection is unknown. This project aims to investigate brain chemistry and circuitry controlling decision making under conflict using a multidisciplinary approach combining behaviour, pharmacogenetics, and sophisticated molecular and functional profiling. The expected outcomes will advance theories regarding the neural organisation and computation of decision making under conflict.Read moreRead less
Discovery Early Career Researcher Award - Grant ID: DE240100614
Funder
Australian Research Council
Funding Amount
$443,007.00
Summary
How does the brain process conflicting information? Learning is the means by which we adapt to our environments. Occasionally, what we learn contradicts our present knowledge about the world. When this occurs, the old and new (contradictory) information compete for control over behaviour. Yet, how the brain processes contradictory information and resolves this competition is poorly understood. This project uses modern genetic tools in rodents to examine how the brain encodes and retrieves contra ....How does the brain process conflicting information? Learning is the means by which we adapt to our environments. Occasionally, what we learn contradicts our present knowledge about the world. When this occurs, the old and new (contradictory) information compete for control over behaviour. Yet, how the brain processes contradictory information and resolves this competition is poorly understood. This project uses modern genetic tools in rodents to examine how the brain encodes and retrieves contradictory information to influence behaviour. The outcomes include new insights regarding the neural basis of adaptive behaviour; and the benefits include an understanding of why we sometimes fail to adapt to change, and disorders characterized by such failures (e.g., anxiety disorders, addiction).Read moreRead less
Neurobiological mechanisms of the interaction between pain and sleep. The project aims to reveal the brain mechanisms behind the interaction between such fundamental biological phenomena as sleep and pain. This highly interdisciplinary project expects to deliver significant insights into how poor sleep changes the brain to increase pain sensitivity in healthy adults, by combining novel lab-based mechanistic sleep and pain manipulations and naturalistic longitudinal observation. The rich multimod ....Neurobiological mechanisms of the interaction between pain and sleep. The project aims to reveal the brain mechanisms behind the interaction between such fundamental biological phenomena as sleep and pain. This highly interdisciplinary project expects to deliver significant insights into how poor sleep changes the brain to increase pain sensitivity in healthy adults, by combining novel lab-based mechanistic sleep and pain manipulations and naturalistic longitudinal observation. The rich multimodal dataset generated by the project will be made publicly available to enhance research transparency and international collaboration. This should provide significant benefits, ultimately opening up ways to improve quality of life and wellbeing of the Australian population.
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Robots as a Social Group: Implications for Human-Robot Interaction. This Project aims to identify psychological factors that can limit the acceptance of robots in the home and workplace. As robots become more pervasive in everyday life, they are also likely to elicit fear, rejection, and even damage. The significance of the Project lies in its social neuroscientific approach to promoting better human-robot interaction by considering robots as a social group. Expect outcomes include theory develo ....Robots as a Social Group: Implications for Human-Robot Interaction. This Project aims to identify psychological factors that can limit the acceptance of robots in the home and workplace. As robots become more pervasive in everyday life, they are also likely to elicit fear, rejection, and even damage. The significance of the Project lies in its social neuroscientific approach to promoting better human-robot interaction by considering robots as a social group. Expect outcomes include theory development about human and robot intergroup acceptance, enhanced institutional and international collaborations, and much needed psychological knowledge for robot designers. Benefits include a detailed understanding of how to increase the acceptance of robots in a wide variety of fields.Read moreRead less
Paving the way for ultra-long haul flights: strategies to mitigate jetlag. This project aims to develop and test strategies to mitigate jetlag, founded on biophysical modelling of circadian rhythms. It sets out to quantify the speed of circadian adaptation of sleep, alertness, and metabolism after transmeridian travel and to maximise speed of adaptation via optimised timing of light exposure, food, and exercise in-flight and on-the-ground. Expected outcomes include powerful models for jetlag str ....Paving the way for ultra-long haul flights: strategies to mitigate jetlag. This project aims to develop and test strategies to mitigate jetlag, founded on biophysical modelling of circadian rhythms. It sets out to quantify the speed of circadian adaptation of sleep, alertness, and metabolism after transmeridian travel and to maximise speed of adaptation via optimised timing of light exposure, food, and exercise in-flight and on-the-ground. Expected outcomes include powerful models for jetlag strategies, ready for application in air travel. The project will directly inform Qantas’ operations for ultra-long haul flights and their international network more broadly. Project outcomes will benefit society and the economy through improving travellers’ alertness, sleep, and reducing the risk of fatigue-related accidents.Read moreRead less
Neurochemical predictors of cognition and the impact of brain stimulation. This project aims to determine how neurochemical equilibrium between excitation and inhibition (E/I balance), across the brain, is associated with executive function and how this balance is influenced by non-invasive brain stimulation. Brain stimulation shows immense promise for enhancing executive function in applied settings, but the neurochemical basis for this is unknown. Using advanced imaging and stimulation techniq ....Neurochemical predictors of cognition and the impact of brain stimulation. This project aims to determine how neurochemical equilibrium between excitation and inhibition (E/I balance), across the brain, is associated with executive function and how this balance is influenced by non-invasive brain stimulation. Brain stimulation shows immense promise for enhancing executive function in applied settings, but the neurochemical basis for this is unknown. Using advanced imaging and stimulation techniques, the project aims to provide comprehensive insights into the causal relationship between stimulation, E/I balance and executive function. Outcomes and benefits include identifying neurochemical characteristics that determine stimulation efficacy and informing the design of protocols for applied use.Read moreRead less