Proteotyping for the rapid identification of pandemic influenza. Future influenza pandemics will develop more rapidly providing a relatively short window with which to survey and assess the nature of the virus and administer effective treatments. Application of a new proteotyping approach will allow strains of pandemic potential to be characterised more directly and rapidly than current surveillance methods.
Anthocyanin Inhibitors to the Influenza Virus. The increasing resistance of circulating influenza strains to current anti-viral inhibitors has prompted an investigation to screen, design, synthesize and evaluate a new class of natural product based inhibitors to the virus employing novel and innovative mass spectrometry, computational and structural approaches. Preliminary studies reveal they offer benefits in terms of a different mode of binding to influenza neuraminidase, remote from many know ....Anthocyanin Inhibitors to the Influenza Virus. The increasing resistance of circulating influenza strains to current anti-viral inhibitors has prompted an investigation to screen, design, synthesize and evaluate a new class of natural product based inhibitors to the virus employing novel and innovative mass spectrometry, computational and structural approaches. Preliminary studies reveal they offer benefits in terms of a different mode of binding to influenza neuraminidase, remote from many known resistance mutations, and may have specific practicality against N1 neuraminidase in H1N1 and H5N1 viruses responsible for all pandemics of the 20th and 21st centuries. The research will enable the potential of these inhibitors to be fully assessed at the molecular level for the first time.Read moreRead less
Predicting the evolution of the influenza virus on mass. Understanding viral reassortment is essential for the development of efficacious vaccines and to prepare for a future influenza pandemic. The research will improve our ability to monitor the evolution of reassorted influenza virus strains using new computer algorithms in concert with the application of bioinformatics and analytical technologies.