Coral-associated viruses: pathogens, mutualists and agents of evolution? Corals host numerous organisms, of which viruses are the least studied. The aim of this project is to characterise the viruses associated with corals and to obtain a detailed understanding of the critical roles that viruses play in coral health, coral bleaching and adaptation of corals to climate change.
Evolution of the marsupial gut microbiome and adaptation to eucalypt toxins. Eucalyptus leaves comprise all or part of the diet of some marsupials including koalas. Gut microbiota assist in the ability of these folivores to tolerate eucalyptus toxins although present understanding of this process is rudimentary. This project aims to use culture-independent molecular methods to identify and characterise gut populations involved in phytochemical detoxification by comparative analysis with diprotod ....Evolution of the marsupial gut microbiome and adaptation to eucalypt toxins. Eucalyptus leaves comprise all or part of the diet of some marsupials including koalas. Gut microbiota assist in the ability of these folivores to tolerate eucalyptus toxins although present understanding of this process is rudimentary. This project aims to use culture-independent molecular methods to identify and characterise gut populations involved in phytochemical detoxification by comparative analysis with diprotodont relatives that are not capable of digesting eucalyptus leaves. This will highlight evolutionary convergence of gut microbiomes in toxic folivores and reveal mechanisms by which microorganisms respond to and metabolise eucalypt toxins. A broader evolutionary context of marsupial digestive function will assist in ongoing conservation efforts.Read moreRead less
The dynamics of evolution: How horizontal gene transfer drives the diversification and adaptation of complex, bacterial communities. The genetic exchange between populations is a prerequisite for the long-term evolution of bacteria, however its short-term dynamics are largely unexplored. This project aims to define the temporal dynamics of gene transfer and how it shapes the genetic composition of entire bacterial communities. Using innovative DNA sequencing technologies and bioinformatics, This ....The dynamics of evolution: How horizontal gene transfer drives the diversification and adaptation of complex, bacterial communities. The genetic exchange between populations is a prerequisite for the long-term evolution of bacteria, however its short-term dynamics are largely unexplored. This project aims to define the temporal dynamics of gene transfer and how it shapes the genetic composition of entire bacterial communities. Using innovative DNA sequencing technologies and bioinformatics, This project aims to offer a significant new understanding of the short-term diversification of communities and how different evolutionary forces shape bacterial function. It will show how bacterial systems can adapt to new environmental conditions and the effect on essential ecosystem functions.Read moreRead less
Defining the evolution of pathogen virulence to enhance rabbit biocontrol. Rabbits impose a major economic and ecological burden on Australia. Biocontrols involving viruses are the best means to regulate rabbit populations, although they often have transient effectiveness. It is therefore essential to determine why some viruses retain the high virulence essential for effective biocontrol, while others are consistently benign. Through bioinformatic and experimental studies of two rabbit viruses w ....Defining the evolution of pathogen virulence to enhance rabbit biocontrol. Rabbits impose a major economic and ecological burden on Australia. Biocontrols involving viruses are the best means to regulate rabbit populations, although they often have transient effectiveness. It is therefore essential to determine why some viruses retain the high virulence essential for effective biocontrol, while others are consistently benign. Through bioinformatic and experimental studies of two rabbit viruses with markedly different virulence, Rabbit Haemorrhagic Disease virus (high virulence) and Australian rabbit calicivirus (low virulence), this project will determine the molecular mechanisms that control virulence and the factors that shape virulence evolution. Ultimately, this research will help improve rabbit biocontrol in Australia.Read moreRead less
Revealing the structure, evolution and sensitivity of symbioses in basal metazoa. This project will explore the complex interactions between each component of the sponge holobiont (virus, bacteria, sponge) during thermal stress. This will also provide the first molecular assessment of sponge viruses and provide insights into how sponges may adapt to a changing climate.
Adaptive ecotyping of the toxic cyanobacterium Cylindrospermopsis raciborskii to predict its invasive capacity. We change the world while other organisms adapt to these new conditions. Cyanobacteria (blue green algae) increasingly dominate water bodies that were previously free of these harmful blooms. To minimise the spread of these algae, this project will study the genetic basis that determines how rapidly they can evolve and adapt to a changing planet.