Nettles & toxic toupees: the molecular weaponry of venomous caterpillars. This project aims to investigate the structure, function and evolution of peptide toxins in venoms made by caterpillars in superfamily Zygaenoidea. Caterpillars in this group are covered in spines that inject pain-causing venoms, and this protects them from vertebrate and invertebrate predators. This project will test if peptides in this venom cause pain by pharmacological modulation of mammalian ion channels and signallin ....Nettles & toxic toupees: the molecular weaponry of venomous caterpillars. This project aims to investigate the structure, function and evolution of peptide toxins in venoms made by caterpillars in superfamily Zygaenoidea. Caterpillars in this group are covered in spines that inject pain-causing venoms, and this protects them from vertebrate and invertebrate predators. This project will test if peptides in this venom cause pain by pharmacological modulation of mammalian ion channels and signalling receptors, and if they have insecticidal properties. The first three-dimensional structures of caterpillar venom peptides will also be solved. Genomes of representatives of two different zygaenoid families will be produced, and genomic techniques will be used to elucidate how venom use evolved at the molecular level.Read moreRead less
Coral-associated viruses: pathogens, mutualists and agents of evolution? Corals host numerous organisms, of which viruses are the least studied. The aim of this project is to characterise the viruses associated with corals and to obtain a detailed understanding of the critical roles that viruses play in coral health, coral bleaching and adaptation of corals to climate change.
The nature of standing genetic variation. This project aims to expand understanding of the genetic variation underlying phenotypic differences among individuals. The nature of genetic variation has broad consequences across biology, from the detection of causal genetic variants to the adaptation of natural populations. This project will take a novel experimental approach to test several long-standing assumptions about the effects of new mutations on individual traits and their joint pleiotropic ....The nature of standing genetic variation. This project aims to expand understanding of the genetic variation underlying phenotypic differences among individuals. The nature of genetic variation has broad consequences across biology, from the detection of causal genetic variants to the adaptation of natural populations. This project will take a novel experimental approach to test several long-standing assumptions about the effects of new mutations on individual traits and their joint pleiotropic effect on fitness. By expanding our understanding of how mutation, selection and drift interact, this project could provide significant improvements in our understanding of the genetic basis of phenotypes, and our ability to predict phenotypic evolution.Read moreRead less
Sex and bottlenecks: understanding the evolutionary dynamics of bacterial adaptation. Bacteria can rapidly adapt to changing environments, often with devastating consequences for humans. However, this adaptive evolution is often limited by strong reductions in population size, in particular during transmission from one host to another. This project aims to investigate whether recombination in bacteria can overcome the limits that such bottlenecks impose on the rate of adaptation. To this end, it ....Sex and bottlenecks: understanding the evolutionary dynamics of bacterial adaptation. Bacteria can rapidly adapt to changing environments, often with devastating consequences for humans. However, this adaptive evolution is often limited by strong reductions in population size, in particular during transmission from one host to another. This project aims to investigate whether recombination in bacteria can overcome the limits that such bottlenecks impose on the rate of adaptation. To this end, it will construct mathematical models and complement them with evolution experiments in bacterial populations. Results from this research aim to generate fundamental insights into the role of recombination in bacterial evolution and will provide guidance for developing management strategies for bacterial pathogens.Read moreRead less
Illuminating the evolutionary history of Australia’s most iconic animals. This project aims to pinpoint the nature and timing of key steps in macropod history and to test how these link with major climatic and biotic changes. Macropods (kangaroos and relatives) are widely considered the marsupial equivalents to hoofed mammals on other continents, but we have a weaker understanding of how their evolution was shaped by environmental change. This project will combine palaeontology, anatomy and gene ....Illuminating the evolutionary history of Australia’s most iconic animals. This project aims to pinpoint the nature and timing of key steps in macropod history and to test how these link with major climatic and biotic changes. Macropods (kangaroos and relatives) are widely considered the marsupial equivalents to hoofed mammals on other continents, but we have a weaker understanding of how their evolution was shaped by environmental change. This project will combine palaeontology, anatomy and genetics to address questions such as how and why ancestral macropods descended from the trees and evolved bipedal hopping, and the upper size limits of the kangaroo “body plan”. This should improve our understanding of the long-term effects of climate change on marsupials, and provide a test of key placental-based evolutionary models.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE150100083
Funder
Australian Research Council
Funding Amount
$540,000.00
Summary
A high throughput phenomics facility for pace of life traits in animals. A high throughput phenomics facility for pace of life traits in animals: This project seeks to create the first high-throughput phenomic facility for animals in Australia. The molecular revolution has brought unprecedented capacity to understand genetic variation. Genetic variation is now better understood and more easily and cheaply characterised than the physical traits that organisms exhibit. Linking phenotypic variation ....A high throughput phenomics facility for pace of life traits in animals. A high throughput phenomics facility for pace of life traits in animals: This project seeks to create the first high-throughput phenomic facility for animals in Australia. The molecular revolution has brought unprecedented capacity to understand genetic variation. Genetic variation is now better understood and more easily and cheaply characterised than the physical traits that organisms exhibit. Linking phenotypic variation to genetic variation represents the major challenge in harnessing the power of the biomolecular age. This facility will accommodate animals from marine, freshwater and terrestrial systems across a diverse array of phyla. It will allow Australian researchers to leverage advances in high throughput genomic technologies to address a major bottleneck in biology.Read moreRead less
Who's calling? Understanding and exploiting signalling system ecology to improve success in trapping cane toads. This project has five major national and community benefits for Australia. It will: 1. provide a much-needed control option for a major pest, 2. actually remove many toads during the course of the study, through trapping at various locations around Australia, 3. support an Australian small business by providing research outcomes that will enable it to develop and market a highly desi ....Who's calling? Understanding and exploiting signalling system ecology to improve success in trapping cane toads. This project has five major national and community benefits for Australia. It will: 1. provide a much-needed control option for a major pest, 2. actually remove many toads during the course of the study, through trapping at various locations around Australia, 3. support an Australian small business by providing research outcomes that will enable it to develop and market a highly desired product, and 4. provide high level, postgraduate training in science. This project directly addresses the National Research Priority goal safeguarding Australia, protecting Australia from invasive … pests, because it will generate new technologies useful for controlling an invasive species.Read moreRead less
Discovery Early Career Researcher Award - Grant ID: DE150101266
Funder
Australian Research Council
Funding Amount
$358,536.00
Summary
Evolutionary and environmental basis of CO2 tolerance in coral reef fishes. This project aims to examine the effects of ocean acidification on coral reef fishes due to increasing atmospheric carbon dioxide (CO2). Physiological performance of fish vary under elevated CO2, but behaviour is consistently, negatively impacted. This project aims to investigate evolutionary trade-offs between behaviour and performance, physiological mechanisms key to compromising, maintaining, or enhancing metabolic pe ....Evolutionary and environmental basis of CO2 tolerance in coral reef fishes. This project aims to examine the effects of ocean acidification on coral reef fishes due to increasing atmospheric carbon dioxide (CO2). Physiological performance of fish vary under elevated CO2, but behaviour is consistently, negatively impacted. This project aims to investigate evolutionary trade-offs between behaviour and performance, physiological mechanisms key to compromising, maintaining, or enhancing metabolic performance under elevated CO2, and the importance of habitat in how fish respond to elevated CO2. As fish play critical roles in marine ecosystems by structuring food webs and driving ecological processes, this information will be critical for predicting the effects of ocean acidification on marine ecosystems and biodiversity.Read moreRead less
The functions of reef fish colour patterns: how did the coral trout get its spots? How did the coral trout get its spots? Why are some reef fish striped yellow and blue while others dress in pink and orange blotches? This project goes beyond just interpreting animal colours and uses a new approach to reveal the meanings of whole body patterns. Uniquely, it does so through the eyes of the fish themselves.
Why does the genetic nearly-null subspace exist? This project aims to determine why nearly-null genetic subspaces exist by simultaneously measuring the input of new mutational variance in these nearly-null subspaces and the selection that acts on these new mutations to result in the observed low levels of standing genetic variance. The ability of organisms to evolve in response to human disturbance, translocation to new environments, or climate variation is governed by the availability of geneti ....Why does the genetic nearly-null subspace exist? This project aims to determine why nearly-null genetic subspaces exist by simultaneously measuring the input of new mutational variance in these nearly-null subspaces and the selection that acts on these new mutations to result in the observed low levels of standing genetic variance. The ability of organisms to evolve in response to human disturbance, translocation to new environments, or climate variation is governed by the availability of genetic variation. Recent advances in multivariate genetic analysis have demonstrated that a substantial proportion of a phenotype described by quantitative traits has very little genetic variance associated with it, and will therefore tend to be subjected to evolutionary limitsRead moreRead less