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Design And Evaluation Of Inhibitors Targeting Serine Proteases In Blood To Alleviate Systemic Inflammatory Response To Coronary Artery Bypass Graft Surgery
Funder
National Health and Medical Research Council
Funding Amount
$317,559.00
Summary
Over 20,000 Australians undergo bypass surgery each year with a 3% mortality rate linked to complications from the procedure. One such common complication is caused by the body’s immune system being activated when the blood comes in contact with the blood bypass pump machine. This project aims to develop new medicines to block this activation of the immune system during bypass surgery to reduce complications and mortality associated with this procedure.
Large-scale Cancer Proteomic Analyses For Improved Prediction Of Drug Response, Patient Prognosis And Clinical Outcome
Funder
National Health and Medical Research Council
Funding Amount
$318,768.00
Summary
Proteomics is the study of all of the proteins encoded by a genome. In this project, I will use a new database of proteomic and clinical data from up to 70,000 cancer samples, and create an approach to correlate proteomic features with drug response, patient prognosis and clinical outcome. The aim of this research will be to use proteomics to better guide treatment decisions, with the potential to significantly improve the health of people with cancer, both in Australia and globally.
Harnessing Systems Biology By Integrating Proteomics And Immunopeptidomics To Understand Prostate Cancer Carcinogenesis, Diagnosis And Treatment
Funder
National Health and Medical Research Council
Funding Amount
$408,768.00
Summary
This ECF proposal aims to systematic profile to proteomic compositions of prostate normal, and cancer cells, and utilise such data to develop innovative systems biology models that will enable accurate prediction of tumour associate antigen (TAA) presentation for both aggressive and nonaggressive prostate cancer. The outcomes of this project will generate urgently needed knowledge for understanding TAA presentation and contribute to identification of tractable targets for vaccine development.
Interactions Between Aberrant Transcriptional Programs And Methylation In Primary Myelodysplasia And Leukaemia.
Funder
National Health and Medical Research Council
Funding Amount
$316,449.00
Summary
Impaired development of blood stem cells leads to haematological disease such as leukaemia. State of the art next-generation sequencing and bioinformatics identified molecular pathways essential for normal blood development and a core set of these genes repressed in leukaemia. Understanding the mechanism by which these genes are re-activated by the non-specific drug azacitidine contributes to the development of new therapeutics with increased efficiency and reduced side effects.