Linkage Infrastructure, Equipment And Facilities - Grant ID: LE180100121
Funder
Australian Research Council
Funding Amount
$384,671.00
Summary
Genomic library infrastructure for ancient environmental samples. This project aims to enable automated genome recovery from diverse environmental samples, without contamination risk. For more than 100 years, environmental scientists have studied diverse organism / environment interactions using a variety of conceptual and technical tools. Recently, studies of ancient and historical DNA have come to complement these tools and to occupy a significant place in environmental studies conducted over ....Genomic library infrastructure for ancient environmental samples. This project aims to enable automated genome recovery from diverse environmental samples, without contamination risk. For more than 100 years, environmental scientists have studied diverse organism / environment interactions using a variety of conceptual and technical tools. Recently, studies of ancient and historical DNA have come to complement these tools and to occupy a significant place in environmental studies conducted over serial time. The project’s addition to the existing dual Ancient DNA complex facility at Griffith University will comprise two liquid handling workstations, each being housed in separate, self-contained, ancient DNA laboratories. The new facility will enable many researchers to have unprecedented access to an ancient DNA facility and a high level of technical support.Read moreRead less
Next-generation genomic resources to tackle parasitic diseases of animals. The revolution in genomics provides unprecedented opportunities to tackle destructive parasitic diseases affecting billions of animals worldwide. Through a synergy of leading-edge technologies and a strong partnership with BGI International, this project aims to deliver major conceptual advances in the understanding of parasitism; an unparalleled skills-base in genomics and bioinformatics; innovative new molecular technol ....Next-generation genomic resources to tackle parasitic diseases of animals. The revolution in genomics provides unprecedented opportunities to tackle destructive parasitic diseases affecting billions of animals worldwide. Through a synergy of leading-edge technologies and a strong partnership with BGI International, this project aims to deliver major conceptual advances in the understanding of parasitism; an unparalleled skills-base in genomics and bioinformatics; innovative new molecular technologies; and new treatments and diagnostic tests as biotechnological outcomes. This leap forward in Australia will substantially enhance the global profile of parasitology research, training and employment opportunities for early career scientists, and improve access to international research funding and networks. Read moreRead less
Identification of new antibacterial agents that inhibit type III secretion. The development of new antibacterial drugs is an unmet global health priority. This project will investigate several plant-derived compounds that have been found to display promising antibacterial activity. This project has the potential to identify compounds that may result in a new antibiotic therapy.
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE120100025
Funder
Australian Research Council
Funding Amount
$380,000.00
Summary
A high-throughput screening and sequencing facility for single cell genomics. Genomics has revolutionised biology, but for most microorganisms this revolution has not arrived because very few can be grown in pure culture. The single cell genomics facility will address this major bottleneck by allowing as little as a single cell in a clinical or environmental setting to be sequenced thereby accelerating new discoveries and outcomes.
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE150100035
Funder
Australian Research Council
Funding Amount
$610,000.00
Summary
A single molecule real-time DNA sequencing facility. A single molecule real-time DNA sequencing facility: A PacBio SMRT sequencing facility will be established and used to accelerate ten specific research programs across a breadth of biological disciplines at two institutions. A specialised high throughput DNA sequencing technology called Single Molecule Real-Time (SMRT) sequencing developed by Pacific Biosciences (PacBio) is revolutionising biological research. SMRT sequencing allows researche ....A single molecule real-time DNA sequencing facility. A single molecule real-time DNA sequencing facility: A PacBio SMRT sequencing facility will be established and used to accelerate ten specific research programs across a breadth of biological disciplines at two institutions. A specialised high throughput DNA sequencing technology called Single Molecule Real-Time (SMRT) sequencing developed by Pacific Biosciences (PacBio) is revolutionising biological research. SMRT sequencing allows researchers to discover important information in DNA and RNA molecules that are missed by other modern DNA sequencing approaches. It is expected that this facility will also be a key infrastructure resource for the wider scientific community, helping to address fundamental questions in biology.Read moreRead less
Bio-recovery of rare earth elements from Australian soils and mine tailings. This project aims to discover how microbes dissolve weathering-resistant phosphate minerals that contain valuable rare earth elements used widely in modern technology. This discovery would create new knowledge in the interdisciplinary fields of biogeochemistry and biohydrometallurgy, using an innovative combination of techniques in metagenomics, microbiology and mineralogy. Expected research outcomes include new, more ....Bio-recovery of rare earth elements from Australian soils and mine tailings. This project aims to discover how microbes dissolve weathering-resistant phosphate minerals that contain valuable rare earth elements used widely in modern technology. This discovery would create new knowledge in the interdisciplinary fields of biogeochemistry and biohydrometallurgy, using an innovative combination of techniques in metagenomics, microbiology and mineralogy. Expected research outcomes include new, more economic and environmentally sustainable biotechnologies for recovering rare earth elements and increasing phosphorus availability in Australian mineral deposits and soils. These outcomes should benefit the mining and agricultural sectors, by decreasing Australia's dependency on overseas REE supply and the use of fertilizers.Read moreRead less
New drugs against parasitic nematodes of livestock animals. New drugs against parasitic nematodes of livestock animals. This project aims to develop an innovative technology platform to deliver novel anti-infectives as biotechnological outcomes, using postgenomics, computing and chemistry. Advanced molecular, computer and chemistry technologies provide unprecedented opportunities to design radically new interventions against socioeconomically important infectious diseases affecting billions of a ....New drugs against parasitic nematodes of livestock animals. New drugs against parasitic nematodes of livestock animals. This project aims to develop an innovative technology platform to deliver novel anti-infectives as biotechnological outcomes, using postgenomics, computing and chemistry. Advanced molecular, computer and chemistry technologies provide unprecedented opportunities to design radically new interventions against socioeconomically important infectious diseases affecting billions of animals worldwide. Anticipated outcomes are the design of radically new chemotherapies to control parasitic diseases, the translation of fundamental research into biotechnological outcomes, international visibility of Australian science, and a solid skills- and knowledge-base in veterinary drug development.Read moreRead less
New anti-parasitic drugs for a global veterinary market. This project aims to establish an advanced, industry-linked pipeline for the development of new drugs against resilient infectious agents (parasites) that cause serious diseases in billions of animals worldwide. The research expects to discover new ways of killing parasites that survive in their host animal, despite being under severe attack by the host immune system. The resultant shift in fundamental understanding will lead to innovative ....New anti-parasitic drugs for a global veterinary market. This project aims to establish an advanced, industry-linked pipeline for the development of new drugs against resilient infectious agents (parasites) that cause serious diseases in billions of animals worldwide. The research expects to discover new ways of killing parasites that survive in their host animal, despite being under severe attack by the host immune system. The resultant shift in fundamental understanding will lead to innovative technologies or products to ameliorate the burden of parasites in livestock animals. Expected socioeconomic benefits include commercial products for end-users and lifting Australia’s scientific knowledge base, reputation in biotechnology, livestock production and investment in translational research.Read moreRead less