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Understanding how dynamic changes in chromatin composition control genome function. DNA is tightly packaged in eukaryotic cells as chromatin. Important genetic processes, such as transcription, require manipulation of chromatin structure to access the DNA. The cell sets up specialised chromatin structures to regulate these processes. Currently, precise molecular details of these specialised structures are limited. This project will push the envelope of an in vitro model chromatin system and dete ....Understanding how dynamic changes in chromatin composition control genome function. DNA is tightly packaged in eukaryotic cells as chromatin. Important genetic processes, such as transcription, require manipulation of chromatin structure to access the DNA. The cell sets up specialised chromatin structures to regulate these processes. Currently, precise molecular details of these specialised structures are limited. This project will push the envelope of an in vitro model chromatin system and determine the architecture of several chromatin states with unique functional implications inside the cell. This will unravel the molecular instructions that define how our genomes are organised, significantly advancing our knowledge of fundamental eukaryotic genome biology and paving the way for the future development of new tools and therapies.Read moreRead less
Effects Of Latrepirdine On Beta Amyloid Clearance, Aggregation And Neurodegeneration In Alzheimer�s Disease
Funder
National Health and Medical Research Council
Funding Amount
$512,647.00
Summary
Alzheimer's disease (AD) is becoming more common with our growing aged population and currently no treatment exists that halts disease progress. The increasing health costs of AD underscore the need for development of any treatment that will slow or halt AD pathogenesis. By understanding the mechanisms of action of a drug [latrepirdine] that has recently shown some promise in phase II clinical trials, related drugs that are more specific and potent will be developed.
Iron, ferroptosis and the biology of ageing. This project aims to determine how and when regulation of iron is lost. Failing iron metabolism during life may dictate the rate of ageing by driving a newly discovered cell death program. Combining biology, chemistry and physics, this collaborative project aims to transform the understanding of the fundamental mechanisms of biological ageing. Anticipated outcomes include new assays for measuring iron in biology and identification of potential pathway ....Iron, ferroptosis and the biology of ageing. This project aims to determine how and when regulation of iron is lost. Failing iron metabolism during life may dictate the rate of ageing by driving a newly discovered cell death program. Combining biology, chemistry and physics, this collaborative project aims to transform the understanding of the fundamental mechanisms of biological ageing. Anticipated outcomes include new assays for measuring iron in biology and identification of potential pathways that regulate death signaling and lifespan. Outcomes will benefit life sciences and biotechnology industries.Read moreRead less
N-glycosylation In Health And Disease: A Key Role For Ost3p And Ost6p In Regulation Of Substrate Specificity.
Funder
National Health and Medical Research Council
Funding Amount
$523,084.00
Summary
Protein glycosylation is the addition of complex sugar chains to specific proteins. Proteins on the surface of cells are often glycosylated, and this is important for controlling the interactions between cells that occur in development, cancer and infection. Glycosylation can be regulated, and our research will characterize the mechanisms of this regulation. This will help us understand exactly how glycosylation is important in cancer and development.
Structure-based Design Of Inhibitors Of Oxidative Protein Folding In Enterobacteriaceae.
Funder
National Health and Medical Research Council
Funding Amount
$523,540.00
Summary
Antibiotic resistance represents a major public health problem. For gram-negative bacteria in particular, the situation is increasingly bleak, with the accumulation of resistance to existing drugs and few if any new drugs in the pipeline. We are using structure-based drug design to develop novel strategies for the treatment of gram-negative bacterial infections.
Biogenesis of the relict plastid of Apicomplexan parasites: the role of a dynamin-related protein in apicoplast division. The Apicomplexa are a group of intracellular parasites that cause several important diseases. Most Apicomplexa contain an organelle called the apicoplast that is indispensable for their survival and that can only form through the division of pre-existing apicoplasts. This project will examine the molecular mechanisms of how this process occurs.
Discovery Early Career Researcher Award - Grant ID: DE180100984
Funder
Australian Research Council
Funding Amount
$365,058.00
Summary
Unravelling the cell biology of a blood vessel. This project aims to understand the molecular mechanisms of vascular regeneration in adult homeostasis. Maintaining a viable circulatory system is essential for organ survival and function. The data generated from this project has the capacity to significantly impact our fundamental understanding of cardiovascular repair and regeneration. This will be of future benefit to many industries including science, bioengineering, healthcare technologies, a ....Unravelling the cell biology of a blood vessel. This project aims to understand the molecular mechanisms of vascular regeneration in adult homeostasis. Maintaining a viable circulatory system is essential for organ survival and function. The data generated from this project has the capacity to significantly impact our fundamental understanding of cardiovascular repair and regeneration. This will be of future benefit to many industries including science, bioengineering, healthcare technologies, and ensuring significant economic outcomes and benefit the Australian community.Read moreRead less
Regulation of 3D Cell Migration by Microtubule-Dependent Processes. The overarching aim of this research is to elucidate the molecular mechanisms that cells use to move in 3D environments: a basic biological function essential to development and homeostasis. During these processes, cells interact with their surroundings where they translate biophysical forces into biochemical signals to adapt their shape to move. This requires distinct signalling, controlled in space and time, to regulate the cr ....Regulation of 3D Cell Migration by Microtubule-Dependent Processes. The overarching aim of this research is to elucidate the molecular mechanisms that cells use to move in 3D environments: a basic biological function essential to development and homeostasis. During these processes, cells interact with their surroundings where they translate biophysical forces into biochemical signals to adapt their shape to move. This requires distinct signalling, controlled in space and time, to regulate the crosstalk between organelles and the cytoskeleton. To date, the role of microtubules remains elusive. Using interdisciplinary approaches combining advanced imaging technology with novel cell biology methods, the project aims to uncover fundamental knowledge about how cells interact with their environment.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE170100021
Funder
Australian Research Council
Funding Amount
$2,168,000.00
Summary
Australian Metabolic Phenotyping Centre (AMPC). This project aims to establish a centre for targeted and exploratory metabolic phenotyping. Metabolic phenotyping quantitatively measures the precursors, intermediates and products of metabolism interacting within a biological system. This project will use high-resolution spectrometry and spectroscopy to generate comprehensive, multi-parameter metabolite data sets for biological samples at the population level, at unprecedented throughput and low c ....Australian Metabolic Phenotyping Centre (AMPC). This project aims to establish a centre for targeted and exploratory metabolic phenotyping. Metabolic phenotyping quantitatively measures the precursors, intermediates and products of metabolism interacting within a biological system. This project will use high-resolution spectrometry and spectroscopy to generate comprehensive, multi-parameter metabolite data sets for biological samples at the population level, at unprecedented throughput and low cost, to address biological and biomedical research needs. This project is expected to make Australian scientists globally competitive in the life sciences including biological, clinical and biomedical, plant and crop sciences, analytical chemistry, toxicology, agriculture, wildlife conservation and sports science, and to drive advances in the data sciences for systems biology.Read moreRead less
Discovery Early Career Researcher Award - Grant ID: DE190100565
Funder
Australian Research Council
Funding Amount
$422,107.00
Summary
A novel role for saturated fatty acids in learning and memory. This project aims to characterise the novel role of the phospholipase A1 pathway in neurotransmission, generating new knowledge on how the saturated fatty acid changes in neurons affect the mobility of neurotransmitter receptors and synaptic vesicles. Learning and memory are thought to result from long-lasting changes in synaptic strength. Whereas the role of polyunsaturated fatty acids in these functions is well known, recent findin ....A novel role for saturated fatty acids in learning and memory. This project aims to characterise the novel role of the phospholipase A1 pathway in neurotransmission, generating new knowledge on how the saturated fatty acid changes in neurons affect the mobility of neurotransmitter receptors and synaptic vesicles. Learning and memory are thought to result from long-lasting changes in synaptic strength. Whereas the role of polyunsaturated fatty acids in these functions is well known, recent findings suggest an unprecedented role for the generation of saturated free fatty acids by phospholipase A1-enzyme. Expected outcomes of this project will be to provide novel conceptual insights into learning, memory and brain capacity.Read moreRead less