Targeted isolation of specific marine bacterial species associated with higher organsims for the purpose of discovering new antimicrobial compounds. Specific bacterial species that are commonly found in association with marine plants and animals often produce active secondary metabolites. The aim of this project is to apply our understanding of these bacterial-host associations to the targeted isolation of novel antimicrobials from the marine environment. While these new compounds will undoubted ....Targeted isolation of specific marine bacterial species associated with higher organsims for the purpose of discovering new antimicrobial compounds. Specific bacterial species that are commonly found in association with marine plants and animals often produce active secondary metabolites. The aim of this project is to apply our understanding of these bacterial-host associations to the targeted isolation of novel antimicrobials from the marine environment. While these new compounds will undoubtedly have a number of commercial applications this project focuses on the development of products for dental hygiene in animals. Generally, the urgent need for new antimicrobial compounds to combat the growing number of microbes that are resistant to current antibiotics highlights the importance of this project.Read moreRead less
Discovery Early Career Researcher Award - Grant ID: DE200101524
Funder
Australian Research Council
Funding Amount
$355,325.00
Summary
Taking Control: Understanding regulation of bacterial iron acquisition. This project aims to uncover the bacterial regulatory networks acting on a family of iron-stealing molecules called siderophores. Bacteria use siderophores to acquire iron from their hosts, the environment, and each other – as such, they have a central role in microbial life. Despite their importance, we have an incomplete knowledge of how these iron-stealing weapons are deployed. This project will develop a new genomics-bas ....Taking Control: Understanding regulation of bacterial iron acquisition. This project aims to uncover the bacterial regulatory networks acting on a family of iron-stealing molecules called siderophores. Bacteria use siderophores to acquire iron from their hosts, the environment, and each other – as such, they have a central role in microbial life. Despite their importance, we have an incomplete knowledge of how these iron-stealing weapons are deployed. This project will develop a new genomics-based, high-throughput technology for defining bacterial gene regulation networks, and use it to understand siderophore control. This will provide new knowledge of siderophore function, enhance understanding of bacterial community and host interactions, and establish leadership in a new genomics technology in Australia.Read moreRead less
Development of an anaerobic bioprocess for hexachlorobenzene destruction. This project will develop a biological process for destruction of a 10,000 tonne hexachlorobenzene stockpile in Sydney Australia. Development of a low energy bioprocess based on recently isolated bacteria will put an end to this ongoing health, environmental and industrial legacy issue and build expertise in bioprocessing for future applications.