Discovery Early Career Researcher Award - Grant ID: DE120100992
Funder
Australian Research Council
Funding Amount
$375,000.00
Summary
The role of neuropeptides driving plasticity in the control of blood pressure and breathing. This project aims to understand how pathways in the brain, that control blood pressure, develop 'memory' after repeated episodes of low oxygen, as occurs in sleep apnoea. Based on the assumption that long-lasting excitatory actions are responsible for this change in nerve behaviour this project will increase knowledge about how the brain controls blood pressure.
Discovery Early Career Researcher Award - Grant ID: DE200100825
Funder
Australian Research Council
Funding Amount
$422,955.00
Summary
Functional insights into the roles of enteric glia. This project aims to review our current definition of enteric glia populations, and our understanding of their communication mechanisms in the mouse and primate colon. It will generate new knowledge of enteric glia biology using advanced microscopy and image analysis. Calcium imaging and novel biosensors will measure cell signalling in enteric glia. It will provide the most comprehensive analysis of glia connectivity, morphology and receptor ex ....Functional insights into the roles of enteric glia. This project aims to review our current definition of enteric glia populations, and our understanding of their communication mechanisms in the mouse and primate colon. It will generate new knowledge of enteric glia biology using advanced microscopy and image analysis. Calcium imaging and novel biosensors will measure cell signalling in enteric glia. It will provide the most comprehensive analysis of glia connectivity, morphology and receptor expression in the primate colon. Expected outcomes include a detailed map of enteric glia and definitions of their basic biology. This project builds on the techniques and collaborations made by the candidate over recent years. This will benefit our basic understanding of enteric glia biology.Read moreRead less
Discovery Early Career Researcher Award - Grant ID: DE190101209
Funder
Australian Research Council
Funding Amount
$390,000.00
Summary
Genes underlying enteric neuron subtype differentiation. This project aims to use new RNA-sequencing technology to identify genes important for differentiation of several major enteric neuron subtypes. Proper development and function of the digestive tract is crucial for good health. Gastrointestinal function relies on the co-ordinated activity of neural circuits in the enteric nervous system. This project will advance Australia's knowledge base and research capabilities in the field basic devel ....Genes underlying enteric neuron subtype differentiation. This project aims to use new RNA-sequencing technology to identify genes important for differentiation of several major enteric neuron subtypes. Proper development and function of the digestive tract is crucial for good health. Gastrointestinal function relies on the co-ordinated activity of neural circuits in the enteric nervous system. This project will advance Australia's knowledge base and research capabilities in the field basic developmental neuroscience, by innovative use of Next Generation RNA-sequencing technology to investigate enteric neuron subtype differentiation. The project outcomes include the generation of neuron subtype specific progenitors from naïve stem cells, which will in the longer term have significant health benefits, as gastrointestinal dysfunction is a large health and economic burden in Australia.Read moreRead less
Discovery Early Career Researcher Award - Grant ID: DE130100537
Funder
Australian Research Council
Funding Amount
$375,000.00
Summary
Neural regulation of immunity following brain injury. Following a brain injury, the brain tries to protect itself by blocking all inflammation. However, this renders the host with impaired immunity and increased risks to infections. The project aims to delineate the mechanisms behind this response, with the expected outcome of highlighting the important interplay between the nervous and immune system.
Discovery Early Career Researcher Award - Grant ID: DE130100223
Funder
Australian Research Council
Funding Amount
$375,000.00
Summary
Characterisation of visceral afferent spinal cord pathways. Sensory nerves in the gut wall are key mediators of chronic visceral pain. This project will characterise how sensory nerves supplying the bowel connect to the spinal cord and the spinal circuits mediating pain perception, providing information to identify sensory pathways underlying visceral pain.
Discovery Early Career Researcher Award - Grant ID: DE180100261
Funder
Australian Research Council
Funding Amount
$365,058.00
Summary
Understanding interactions between gut epithelial stem cells and neurons. This project aims to investigate the interaction between gut neurons and the epithelial stem cell compartment, as well as the relationship between age-related loss of enteric neurons and changes in gut epithelial stem cells. This project will include novel co-culturing of organoids and enteric neurospheres, which will identify mechanisms by which nerves influence the epithelia. The outcome of the project will be a better u ....Understanding interactions between gut epithelial stem cells and neurons. This project aims to investigate the interaction between gut neurons and the epithelial stem cell compartment, as well as the relationship between age-related loss of enteric neurons and changes in gut epithelial stem cells. This project will include novel co-culturing of organoids and enteric neurospheres, which will identify mechanisms by which nerves influence the epithelia. The outcome of the project will be a better understanding of the biology of the body’s most highly proliferative, long-lived stem cells, intestinal epithelial stem cells. This could have significant long term impact on the quality of life in an ageing population.Read moreRead less