Discovery Early Career Researcher Award - Grant ID: DE200101061
Funder
Australian Research Council
Funding Amount
$424,848.00
Summary
Single particle imaging: x-ray imaging of individual dynamic biomolecules. X-ray lasers produce powerful ultra-short pulses of light that can take temporal snap shots of small radiation-sensitive biological complexes. Thanks to superconducting technology, the next generation of x-ray lasers will be able to produce x-ray pulses at greater rates than ever before. But because of the sheer number of possible molecular configurations, these molecular movies will have only a small amount of data per f ....Single particle imaging: x-ray imaging of individual dynamic biomolecules. X-ray lasers produce powerful ultra-short pulses of light that can take temporal snap shots of small radiation-sensitive biological complexes. Thanks to superconducting technology, the next generation of x-ray lasers will be able to produce x-ray pulses at greater rates than ever before. But because of the sheer number of possible molecular configurations, these molecular movies will have only a small amount of data per frame, posing an enormous challenge for current imaging methods. I aim to meet this challenge by developing an innovative multi-conformational image reconstruction algorithm. This will provide a new window into the molecular dynamics of biological systems, the building blocks of life, and enable rational drug design.Read moreRead less