The molecular basis of cold adaptation: an integrated genomic and proteomic study of Antarctic archaea. The project enables Australia to remain a world leader in extremophiles, cold adaptation and Antarctic biology, strengthening the reputation Australian scientists have in scientific programs of global significance and fostering the interests of the international community in sciences ranging from bioprospecting to the search for extraterrestrial life. National benefit is directly derived from ....The molecular basis of cold adaptation: an integrated genomic and proteomic study of Antarctic archaea. The project enables Australia to remain a world leader in extremophiles, cold adaptation and Antarctic biology, strengthening the reputation Australian scientists have in scientific programs of global significance and fostering the interests of the international community in sciences ranging from bioprospecting to the search for extraterrestrial life. National benefit is directly derived from technological innovation and training local scientists in modern biology of environmental microorganisms. The Antarctic microorganisms provide unique compounds, enzymes and molecules for biotechnology and industry. Insight will be gained into the critical role that methanogens play in the global carbon cycle and global warming.Read moreRead less
Structure and temperature adaptation of chaperonin TF55 from Sulfolobus solfataricus. Our work has future potential both for biotechnology and for medical therapies. The cages formed by chaperonin subunits and their ability to bind to specific targets could lead to their application as nano-vesicles, could facilitate expression of eukaryotic proteins in bacteria and could help to prevent or dissolve protein aggregates. With Australia's ageing population, we can expect an increasing prevalence of ....Structure and temperature adaptation of chaperonin TF55 from Sulfolobus solfataricus. Our work has future potential both for biotechnology and for medical therapies. The cages formed by chaperonin subunits and their ability to bind to specific targets could lead to their application as nano-vesicles, could facilitate expression of eukaryotic proteins in bacteria and could help to prevent or dissolve protein aggregates. With Australia's ageing population, we can expect an increasing prevalence of pathologies such as Alzheimer's and Parkinson's disease and other diseases that arise from protein mis-folding and aggregation, including myopathies and cataracts. A participation of chaperonins has been implicated in these age-related diseases and demands detailed structural and functional investigations.Read moreRead less
The role of mycorrhizal fungi in nutrient supply and habitat specificity of the rare underground orchid (Rhizanthella gardneri). The underground orchid (Rhizanthella gardneri) is an extremely rare achlorophyllous myco-heterotroph that shares a mycorrhizal fungus with broom bush (Melaleuca uncinata). This project will investigate habitat requirements for R. gardneri and assess the orchid dependence on M. uncinata for carbon and nutrient supply. We will measure magnitude and timing of nutrient a ....The role of mycorrhizal fungi in nutrient supply and habitat specificity of the rare underground orchid (Rhizanthella gardneri). The underground orchid (Rhizanthella gardneri) is an extremely rare achlorophyllous myco-heterotroph that shares a mycorrhizal fungus with broom bush (Melaleuca uncinata). This project will investigate habitat requirements for R. gardneri and assess the orchid dependence on M. uncinata for carbon and nutrient supply. We will measure magnitude and timing of nutrient and carbon transfers between M. uncinata roots, fungal hyphae and R. gardneri using stable isotope techniques. This project will provide knowledge essential for conserving the underground orchid, a unique Australian plant, and other critically endangered orchids.Read moreRead less
THE BIOLOGY OF COLD ADAPTED EXTREMOPHILES: AN INTEGRATED GENOMIC-PROTEIN ANALYSIS APPROACH. Extremophiles are microorganisms that can thrive in otherwise inhospitable environments. Most extremophiles are Archaea; an order of life separate from Bacteria and Eucaryotes. The project will generate the first genome sequence that was initiated in Australia, and the first genome sequence of any cold adapted organism. Associated functional studies include global analyses of protein expression (proteo ....THE BIOLOGY OF COLD ADAPTED EXTREMOPHILES: AN INTEGRATED GENOMIC-PROTEIN ANALYSIS APPROACH. Extremophiles are microorganisms that can thrive in otherwise inhospitable environments. Most extremophiles are Archaea; an order of life separate from Bacteria and Eucaryotes. The project will generate the first genome sequence that was initiated in Australia, and the first genome sequence of any cold adapted organism. Associated functional studies include global analyses of protein expression (proteomics) and mRNA expression using micro-arrays, and work targeted at RNA binding proteins and protein folding systems involved in the thermally sensitive process of protein synthesis. The nature and scope of the work will impact on fundamental cellular processes and provide enormous innovative biotechnological potential.Read moreRead less
The conversion of remote location natural gas to fuels and chemicals. The objectives of the research programme will be to develop novel science, engineering and technology that will allow cost efficient conversion of remote gas reserves to liquid fuels and/or chemicals with minimal greenhouse gas emissions. The significance of the proposal rests in the fact that Australia has large remote location gas fields that cannot be exploited but faces, within ten years, trillion dollars a year balance of ....The conversion of remote location natural gas to fuels and chemicals. The objectives of the research programme will be to develop novel science, engineering and technology that will allow cost efficient conversion of remote gas reserves to liquid fuels and/or chemicals with minimal greenhouse gas emissions. The significance of the proposal rests in the fact that Australia has large remote location gas fields that cannot be exploited but faces, within ten years, trillion dollars a year balance of payments deficits due to a shortgae of liquid fuels. The development of new processes for gas to liquids conversion and new technology for existing processes is the essential aim of the proposed research.Read moreRead less