Development of a multivariate physiologic state space analysis framework for characterising functional properties of the cardiovascular system. Pathologies of the cardiovascular system arising from heart diseases make a major contribution to morbidity and mortality in the Australian community. This project will provide new diagnostic modalities based on advanced noninvasive bioinstrumentation, signal processing and model-based analytical methods to identify early signs of developing disease or t ....Development of a multivariate physiologic state space analysis framework for characterising functional properties of the cardiovascular system. Pathologies of the cardiovascular system arising from heart diseases make a major contribution to morbidity and mortality in the Australian community. This project will provide new diagnostic modalities based on advanced noninvasive bioinstrumentation, signal processing and model-based analytical methods to identify early signs of developing disease or the acute exacerbation of existing disease. The impact of these new technologies on the early diagnosis and improved triaging of patients in emergency departments is potentially profound and could result in improved healthcare outcomes for the patients and reduced admissions to hospital as well as the development of a substantial international market.Read moreRead less
A Novel Geometric Approach to Shocks in Reaction-Nonlinear Diffusion Models. Reaction-nonlinear diffusion models play a vital role in the study of cell migration and population dynamics. However, the presence of aggregation, or backward diffusion, leads to the formation of shock waves - distinct, sharp interfaces between different populations of densities of cells - and the breakdown of the model. This project will develop new geometric methods to explain the formation and temporal evolution of ....A Novel Geometric Approach to Shocks in Reaction-Nonlinear Diffusion Models. Reaction-nonlinear diffusion models play a vital role in the study of cell migration and population dynamics. However, the presence of aggregation, or backward diffusion, leads to the formation of shock waves - distinct, sharp interfaces between different populations of densities of cells - and the breakdown of the model. This project will develop new geometric methods to explain the formation and temporal evolution of these shock waves, while simultaneously unifying existing regularisation techniques under a single, geometric banner. It will devise innovative tools in singular perturbation theory and stability analysis that will identify key parameters in the creation of shock waves, as well as their dynamic behaviour.Read moreRead less
Bodies in space. By investigating how a change in shape of the human body can produce a change in spatial orientation, the project will bring a fundamental advance of knowledge in the intersection of applied mathematics, sports science and mechanical engineering. These knowledge advances will lead to a novel theory regarding the control of the aerial dynamics of athletes, specifically springboard and platform divers. When applied in collaboration with world class Australian athletes, this theory ....Bodies in space. By investigating how a change in shape of the human body can produce a change in spatial orientation, the project will bring a fundamental advance of knowledge in the intersection of applied mathematics, sports science and mechanical engineering. These knowledge advances will lead to a novel theory regarding the control of the aerial dynamics of athletes, specifically springboard and platform divers. When applied in collaboration with world class Australian athletes, this theory will result in innovative platform and springboard diving techniques and improved performance. The reach of new insights generated by this work extends to many other fields, including robotics, spacecraft dynamics and nano technology.Read moreRead less
Discovery Early Career Researcher Award - Grant ID: DE180101098
Funder
Australian Research Council
Funding Amount
$374,200.00
Summary
New mathematical theory for fluid motion on surfaces with holes. This project aims to develop new explicit mathematical results to enhance the understanding of potential theory – a fundamental area of mathematics - on surfaces with complicating geometrical properties. There are very few such fundamental results on complicated curved surfaces, such as those with holes. This project should provide a toolbox for solving many different mathematical problems on curved surfaces. The new results should ....New mathematical theory for fluid motion on surfaces with holes. This project aims to develop new explicit mathematical results to enhance the understanding of potential theory – a fundamental area of mathematics - on surfaces with complicating geometrical properties. There are very few such fundamental results on complicated curved surfaces, such as those with holes. This project should provide a toolbox for solving many different mathematical problems on curved surfaces. The new results should also have application to the analysis of fluid flows over porous media and practical engineering structures.Read moreRead less
What predictions can I trust? Stability of chaotic random dynamical systems. This project aims to make significant progress on the intricate question of global stability of non-autonomous chaotic dynamical systems. Using ergodic theory, this project expects to determine when and how errors in dynamical models that are small and frequent, or large and infrequent, can cause dramatic changes in meaningful mathematical model outputs. Expected outcomes include the discovery of mathematical mechanisms ....What predictions can I trust? Stability of chaotic random dynamical systems. This project aims to make significant progress on the intricate question of global stability of non-autonomous chaotic dynamical systems. Using ergodic theory, this project expects to determine when and how errors in dynamical models that are small and frequent, or large and infrequent, can cause dramatic changes in meaningful mathematical model outputs. Expected outcomes include the discovery of mathematical mechanisms underlying large-scale (in)stability for time-dependent dynamical systems, and reliable numerical methods for detecting instabilities. This research is expected to lead to improved characterisations of shocks or collapse in externally driven dynamical systems and assist scientists to gauge which predictions they can trust.Read moreRead less
A geometric theory for travelling waves in advection-reaction-diffusion models. Cell migration patterns often develop distinct sharp interfaces between identifiably different cell populations within a tissue. This research will develop new geometric methods for the mathematical analysis of cell migration models, and will design diagnostic tools to identify key parameters that cause and control these patterns and interfaces.
Maintenance Optimisation in Rail Infrastructure Systems for Coal and
Iron Ore Exports. Coal and iron ore exports, worth around 55 per cent of Australia's export earnings, critically depend on the transport capacity provided by Australia's rail infrastructure. Maintenance plays a crucial role in ensuring that infrastructure components are in a condition to provide safe, reliable, and efficient transport. However maintenance activities also reduce the system capacity, and are costly. It is thus c ....Maintenance Optimisation in Rail Infrastructure Systems for Coal and
Iron Ore Exports. Coal and iron ore exports, worth around 55 per cent of Australia's export earnings, critically depend on the transport capacity provided by Australia's rail infrastructure. Maintenance plays a crucial role in ensuring that infrastructure components are in a condition to provide safe, reliable, and efficient transport. However maintenance activities also reduce the system capacity, and are costly. It is thus critical to sustaining the growth and competitiveness of Australia's coal and iron ore exports that maintenance is optimised so as to maximise system efficiency and delivered capacity. The project aims to achieve this by the development of new decision support technologies embedding innovative decision-making models and algorithms.Read moreRead less
Mathematical modelling can provide vital information on the effectiveness and practical implementation of microbicides and vaccines against HIV. This project will produce mathematical models of the earliest stages of HIV infection suitable for investigation of the implementation of vaccines and microbicides. It will provide a framework to investigate why these interventions have performed poorly to date, and how these may be better implemented.
New mathematics to quantify fluctuations and extremes in dynamical systems. Many problems in the natural world result from the cumulative effect of extreme events in complex dynamical systems. Dynamical models of ecological and physical processes have internal variables that can combine to produce large observable changes. Quantitative estimation of the variability of these chaotic models is difficult because of the time dependence of the dynamics and their “long memory” due to significant deter ....New mathematics to quantify fluctuations and extremes in dynamical systems. Many problems in the natural world result from the cumulative effect of extreme events in complex dynamical systems. Dynamical models of ecological and physical processes have internal variables that can combine to produce large observable changes. Quantitative estimation of the variability of these chaotic models is difficult because of the time dependence of the dynamics and their “long memory” due to significant deterministic components. This project aims to develop mathematics and numerics to accurately quantify and assess these complicated variations. The project expects to provide powerful tools to predict harmful outcomes in biogeophysical systems, and assist with the development of mitigation strategies.Read moreRead less