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Foundations of a good egg: correctly transitioning from mitosis to meiosis. Production of viable offspring is essential to the survival of any species. In all sexually reproducing species, this requires a unique cell type, the germ cell. Germ cells undergo a special type of cell division, called meiosis, so that they can eventually produce gametes (sperm in males and eggs in females). This project aims to discover how germ cells halt the standard form of cell division, called mitosis, and initia ....Foundations of a good egg: correctly transitioning from mitosis to meiosis. Production of viable offspring is essential to the survival of any species. In all sexually reproducing species, this requires a unique cell type, the germ cell. Germ cells undergo a special type of cell division, called meiosis, so that they can eventually produce gametes (sperm in males and eggs in females). This project aims to discover how germ cells halt the standard form of cell division, called mitosis, and initiate meiotic division instead. It is important to understand all the fundamental processes that occur during normal germ cell development so that, in the future, we can use this knowledge to support agricultural advances, rescue endangered species and solve human problems such as infertility and genetic disease.Read moreRead less
New insights into female reproductive tract formation and tubulogenesis. Aims: This project aims to improve our understanding of female reproductive tract formation by studying its developmental origins. Most of the female reproductive tract derives from a pair of embryonic tubes called Müllerian ducts, the formation of which is incompletely understood. Significance: Using chicken and mouse models and innovative genetic approaches, the project will undercover novel genes and cellular pathways in ....New insights into female reproductive tract formation and tubulogenesis. Aims: This project aims to improve our understanding of female reproductive tract formation by studying its developmental origins. Most of the female reproductive tract derives from a pair of embryonic tubes called Müllerian ducts, the formation of which is incompletely understood. Significance: Using chicken and mouse models and innovative genetic approaches, the project will undercover novel genes and cellular pathways in Müllerian duct formation. Expected outcomes: This work will enhance knowledge in the biological sciences, in the area of female reproduction and how tubes form in biological systems. Benefits: It will train research scientists, develop collaborations and enhance Australia’s high standing in the field of reproduction.Read moreRead less