Development of Novel Pesticidal Agents. We have discovered a family of naturally occurring plant proteins called the cyclotides that have potent insecticidal activity against Helicoverpa species, one of the major pests on cotton and corn in Australia and world wide. Preliminary evidence has shown that they also have activity against major pests to livestock in Australia, including sheep blowflies. To develop these proteins as potential pesticidal agents it is necessary to understand the struct ....Development of Novel Pesticidal Agents. We have discovered a family of naturally occurring plant proteins called the cyclotides that have potent insecticidal activity against Helicoverpa species, one of the major pests on cotton and corn in Australia and world wide. Preliminary evidence has shown that they also have activity against major pests to livestock in Australia, including sheep blowflies. To develop these proteins as potential pesticidal agents it is necessary to understand the structural basis for their activity. We will do this by chemically synthesising peptides with selected residues mutated to determine their effects on activity.Read moreRead less
Peptidic spider toxins: a novel paradigm for control of insect pests. Many insects are serious pests of Australian crops, livestock, and pets. Australian farmers spend about $300 million per annum on insecticides and acaricides, while Australian consumers spend more than $100 million annually on insecticides for use around the home and garden, and on pets. Viruses disseminated by insects are also responsible for diseases such as dengue, Japanese encephalitis, and Ross River fever. Unfortunately, ....Peptidic spider toxins: a novel paradigm for control of insect pests. Many insects are serious pests of Australian crops, livestock, and pets. Australian farmers spend about $300 million per annum on insecticides and acaricides, while Australian consumers spend more than $100 million annually on insecticides for use around the home and garden, and on pets. Viruses disseminated by insects are also responsible for diseases such as dengue, Japanese encephalitis, and Ross River fever. Unfortunately, many of these insect pests have developed resistance to chemical insecticides. The aim of this research program is to develop a new generation of environmentally-friendly natural products and insect-resistant crops that can be used to control insect pests on farms and around the home and garden.Read moreRead less
Optimising the Strategy for Breeding Micronutrient-Dense Staple Foods that Improve Human health and Nutrition. The project is part of a new paradigm for agriculture in which staple crops are bred with greater micronutrient density to improve human health. It generates strategic basic information on how nutrients interact in the body of animal models in absorption, transport and utilisation that will allow plant breeders to optimise the breeding strategy for maximum outcomes in health and minimum ....Optimising the Strategy for Breeding Micronutrient-Dense Staple Foods that Improve Human health and Nutrition. The project is part of a new paradigm for agriculture in which staple crops are bred with greater micronutrient density to improve human health. It generates strategic basic information on how nutrients interact in the body of animal models in absorption, transport and utilisation that will allow plant breeders to optimise the breeding strategy for maximum outcomes in health and minimum breeding cost. Animals deficient in the nutrients of most concern (iron, zinc, vitamin A - and inulin) will be fed new varieties with enhanced levels of these factors, and from the responses, a superior strategy will be developed.Read moreRead less