Linkage Infrastructure, Equipment And Facilities - Grant ID: LE240100135
Funder
Australian Research Council
Funding Amount
$880,000.00
Summary
An ion mobility-mass spectrometry based platform for structural proteomics. This project aims to establish a nationally unique facility dedicated to structural proteomics, combining high resolution ion mobility mass spectrometry with advanced separation, hydrogen/deuterium exchange and imaging platforms. Such technology is critical to characterise 3D biomacromolecular structures, dynamics, interactions and spatial location on a proteome-wide scale, and overcome current analytical limitations for ....An ion mobility-mass spectrometry based platform for structural proteomics. This project aims to establish a nationally unique facility dedicated to structural proteomics, combining high resolution ion mobility mass spectrometry with advanced separation, hydrogen/deuterium exchange and imaging platforms. Such technology is critical to characterise 3D biomacromolecular structures, dynamics, interactions and spatial location on a proteome-wide scale, and overcome current analytical limitations for structure determination from complex biological samples, particularly for closely related (isomeric) components. Servicing a diverse research community, this will enable new molecular insights to better understand the natural world, and accelerate cutting edge biotechnology advances intersecting life and chemical sciences.Read moreRead less
Industrial Transformation Training Centres - Grant ID: IC220100035
Funder
Australian Research Council
Funding Amount
$4,958,927.00
Summary
ARC Training Centre for Hyphenated Analytical Separation Technologies . The toughest analytical science challenges typically require advanced analytical technologies to acquire the desired solutions. In the field of separation science this inevitably involves hyphenated separation technologies, specifically the combination of chromatography and mass spectrometry. Advancing this technology to its full capability requires the collaborative strength of academic, industry and end-user partnerships, ....ARC Training Centre for Hyphenated Analytical Separation Technologies . The toughest analytical science challenges typically require advanced analytical technologies to acquire the desired solutions. In the field of separation science this inevitably involves hyphenated separation technologies, specifically the combination of chromatography and mass spectrometry. Advancing this technology to its full capability requires the collaborative strength of academic, industry and end-user partnerships, providing the materials and inspiration for young researchers to apply novel hyphenated methods to complex environmental and industrial systems. This Centre will deliver fundamental developments in hyphenated technologies, new analytical capability, and applied outcomes across multiple end-user groups and interests. Read moreRead less
Early Career Industry Fellowships - Grant ID: IE230100593
Funder
Australian Research Council
Funding Amount
$465,237.00
Summary
Membrane-based real-time ammonia monitoring system for sewage treatment. This project aims to develop a real-time, calibration-free, low-maintenance ammoniacal nitrogen monitoring system to assist in optimised wastewater treatment control. This project expects to generate new knowledge in the area of sensing technology using a self-developed membrane-based analytical principle, which overcomes the challenge of directly and accurately determining ammonia in a harsh wastewater environment. Expecte ....Membrane-based real-time ammonia monitoring system for sewage treatment. This project aims to develop a real-time, calibration-free, low-maintenance ammoniacal nitrogen monitoring system to assist in optimised wastewater treatment control. This project expects to generate new knowledge in the area of sensing technology using a self-developed membrane-based analytical principle, which overcomes the challenge of directly and accurately determining ammonia in a harsh wastewater environment. Expected outcomes include new theories in membrane-based sensing techniques and a market-ready field-based ammonia analytical system. This should provide significant benefits, such as a new technology for optimising wastewater treatment and reducing emissions and a valuable analytical tool to safeguard effluent quality.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE240100039
Funder
Australian Research Council
Funding Amount
$470,000.00
Summary
Advanced HR-ICP-MS facility for marine, Antarctic and environmental samples. This proposal seeks support for a shared High Resolution Inductively Coupled Plasma Mass Spectrometry facility for Tasmanian researchers. The existing UTAS instrument is approaching end-of-life and is becoming increasingly unreliable. Access to enhanced capabilities embodied in a rejuvenated facility, along with a renewed lifespan, is essential for continued analysis of ultra-trace elements and isotopes in challenging s ....Advanced HR-ICP-MS facility for marine, Antarctic and environmental samples. This proposal seeks support for a shared High Resolution Inductively Coupled Plasma Mass Spectrometry facility for Tasmanian researchers. The existing UTAS instrument is approaching end-of-life and is becoming increasingly unreliable. Access to enhanced capabilities embodied in a rejuvenated facility, along with a renewed lifespan, is essential for continued analysis of ultra-trace elements and isotopes in challenging samples from southern environments. The new instrument will allow TAS researchers and their (inter)national collaborators to undertake world-leading research, enhancing competitive profiles in a diverse range of research areas (oceanography, analytical chemistry, Antarctic studies, environmental assessment, geochemistry). Read moreRead less
High specificity nanosensors for glycobiology . This project aims to develop high specificity glycosensors for identifying and characterising carbohydrates. These glycosensors are expected to generate detailed information on carbohydrate stereochemical structure and how this controls protein-carbohydrate binding and other interactions fundamental to biochemical processes. This innovative nanotechnology aims to deliver a new capability for understanding cellular recognition and antigen binding me ....High specificity nanosensors for glycobiology . This project aims to develop high specificity glycosensors for identifying and characterising carbohydrates. These glycosensors are expected to generate detailed information on carbohydrate stereochemical structure and how this controls protein-carbohydrate binding and other interactions fundamental to biochemical processes. This innovative nanotechnology aims to deliver a new capability for understanding cellular recognition and antigen binding mechanisms. The expected outcomes are new tools for glycobiology and research into carbohydrate structure-function relationships, strengthening Australia’s global reputation in nanosensors with an incisive analytical technology for biomedical sciences and the many industries utilising carbohydrates.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE240100038
Funder
Australian Research Council
Funding Amount
$670,000.00
Summary
A multimodal infrared, Raman and fluorescence submicron imaging microscope. A new multimodal microscope system incorporating infrared, Raman and fluorescence imaging can study the chemical composition of single bacteria, plants, small organisms along with hard and soft materials at an unprecedented level of detail. This breakthrough technology has various applications in biology, aquatic chemistry, nanochemistry and forensic archaeology. The system will also support sustainable chemistry, materi ....A multimodal infrared, Raman and fluorescence submicron imaging microscope. A new multimodal microscope system incorporating infrared, Raman and fluorescence imaging can study the chemical composition of single bacteria, plants, small organisms along with hard and soft materials at an unprecedented level of detail. This breakthrough technology has various applications in biology, aquatic chemistry, nanochemistry and forensic archaeology. The system will also support sustainable chemistry, material analysis, green energy and battery development, placing Australia at the forefront of multimodal materials characterisation. Overall, this advancement will deepen our understanding of the chemical and biological world and have broad-reaching benefits across multiple disciplines.
Read moreRead less
Improved electrophoretic analyser for water quality monitoring. This proposal will advance the Australian made Eco Detection portable electrophoretic analyser for autonomous monitoring of water chemistry - the Eco Sensor. We will re-design and miniaturise the fluidic manifold to reduce capital- and per-sample cost, increase the sensitivity of nutrients - nitrate and phospate - by 100-times in both fresh- and sea-waters, and develop new ultra-sensitive reagents for heavy metal detection at enviro ....Improved electrophoretic analyser for water quality monitoring. This proposal will advance the Australian made Eco Detection portable electrophoretic analyser for autonomous monitoring of water chemistry - the Eco Sensor. We will re-design and miniaturise the fluidic manifold to reduce capital- and per-sample cost, increase the sensitivity of nutrients - nitrate and phospate - by 100-times in both fresh- and sea-waters, and develop new ultra-sensitive reagents for heavy metal detection at environmentally regulated levels. This will provide a single platform for at-site near-real-time monitoring of water chemistry for agricultural, mining, water corporations and other industries that use and/or discharge water to the environment. Read moreRead less
Homogenous Antibody-Metal Conjugates For Immuno-Mass Spectrometry Imaging. This project aims to use bespoke metal labels and high-resolution mass spectrometry imaging to address current shortcomings in approaches that visualise and measure proteins in cells and tissue. It expects to substantially increase the utility of immuno-mass spectrometry imaging technology to analyses that are refractory to current techniques and workflows. Expected outcomes include metal probes that facilitate the spatia ....Homogenous Antibody-Metal Conjugates For Immuno-Mass Spectrometry Imaging. This project aims to use bespoke metal labels and high-resolution mass spectrometry imaging to address current shortcomings in approaches that visualise and measure proteins in cells and tissue. It expects to substantially increase the utility of immuno-mass spectrometry imaging technology to analyses that are refractory to current techniques and workflows. Expected outcomes include metal probes that facilitate the spatial quantification of multiple biomolecules on a single histological section, providing significant benefits to bioscience laboratories that require complex workflows to visualise and obtain quantitative data on the expression of biomolecules.Read moreRead less
Unlocking the potential of poly(ionic liquids) for electrochemical sensing. This project aims to create new science that will enable the development of low-cost, miniaturised electrochemical sensors based on poly-ionic liquids. The chemistry of the materials will be tuned to selectively detect hazardous pollutants to enable trace concentration detection at analytically relevant levels. Fundamental behaviour of gases and solid contaminants dissolved in poly-ionic liquid/ionic liquid membranes wil ....Unlocking the potential of poly(ionic liquids) for electrochemical sensing. This project aims to create new science that will enable the development of low-cost, miniaturised electrochemical sensors based on poly-ionic liquids. The chemistry of the materials will be tuned to selectively detect hazardous pollutants to enable trace concentration detection at analytically relevant levels. Fundamental behaviour of gases and solid contaminants dissolved in poly-ionic liquid/ionic liquid membranes will be uncovered, and their performance for sensing in real environments will be examined. It is expected that these advances will transform detection methods by taking sensing out of the lab and in to the hands of the everyday person, giving rapid and accurate knowledge about the concentration of hazards in the environment.Read moreRead less