Linkage Infrastructure, Equipment And Facilities - Grant ID: LE240100135
Funder
Australian Research Council
Funding Amount
$880,000.00
Summary
An ion mobility-mass spectrometry based platform for structural proteomics. This project aims to establish a nationally unique facility dedicated to structural proteomics, combining high resolution ion mobility mass spectrometry with advanced separation, hydrogen/deuterium exchange and imaging platforms. Such technology is critical to characterise 3D biomacromolecular structures, dynamics, interactions and spatial location on a proteome-wide scale, and overcome current analytical limitations for ....An ion mobility-mass spectrometry based platform for structural proteomics. This project aims to establish a nationally unique facility dedicated to structural proteomics, combining high resolution ion mobility mass spectrometry with advanced separation, hydrogen/deuterium exchange and imaging platforms. Such technology is critical to characterise 3D biomacromolecular structures, dynamics, interactions and spatial location on a proteome-wide scale, and overcome current analytical limitations for structure determination from complex biological samples, particularly for closely related (isomeric) components. Servicing a diverse research community, this will enable new molecular insights to better understand the natural world, and accelerate cutting edge biotechnology advances intersecting life and chemical sciences.Read moreRead less