Linkage Infrastructure, Equipment And Facilities - Grant ID: LE240100086
Funder
Australian Research Council
Funding Amount
$510,000.00
Summary
Integrated multimodal microscopy facility for single molecule analysis. This project aims to establish an integrated multimodal microscopy facility in Australia for extensive structural characterization of functional and biological materials at the nanoscale and single molecule level. Discoveries using the facility will provide new insights into the relationship between molecules, materials, and their functions. The key outcomes and benefits of this facility are to i) strengthen the research eff ....Integrated multimodal microscopy facility for single molecule analysis. This project aims to establish an integrated multimodal microscopy facility in Australia for extensive structural characterization of functional and biological materials at the nanoscale and single molecule level. Discoveries using the facility will provide new insights into the relationship between molecules, materials, and their functions. The key outcomes and benefits of this facility are to i) strengthen the research effort in materials science and biotechnology, ii) advance the development of functional materials for biosensing and energy storage, and iii) create new catalysts for green energy conversion. The funding will ensure researchers have access to the latest technology critical to maintaining world-class research.Read moreRead less
Rational design of array-based nanozyme sensors. The project aims to obtain a deep understanding of molecular interactions at the nano-bio interface, and use this knowledge to develop a robust sensor technology for the rapid detection of foodborne pathogens in complex samples. The project proposes to employ an innovative approach that mimics the senses of smell and taste, where an array of aptamers are expected to work in synergy to precisely identify a target, providing an edge over current sen ....Rational design of array-based nanozyme sensors. The project aims to obtain a deep understanding of molecular interactions at the nano-bio interface, and use this knowledge to develop a robust sensor technology for the rapid detection of foodborne pathogens in complex samples. The project proposes to employ an innovative approach that mimics the senses of smell and taste, where an array of aptamers are expected to work in synergy to precisely identify a target, providing an edge over current sensing technologies. Expected outcomes include a ready-to-go analytical tool for the detection of food contaminants. This should provide significant economic, health, and social benefits through supporting Australian food and health sectors, and the potential commercialisation of sensor technologies.Read moreRead less
Discovery of new metabolic functions in Plasmodium parasites. This research will provide new understanding about the metabolism of parasites, such as those that cause malaria. These parasites have evolved bespoke metabolic networks to survive in diverse host environments including mosquitos and humans. Previous studies have revealed many unique genes and metabolites in these organisms, but their biochemical function is not known. This project will use state-of-the-art metabolomics and proteomics ....Discovery of new metabolic functions in Plasmodium parasites. This research will provide new understanding about the metabolism of parasites, such as those that cause malaria. These parasites have evolved bespoke metabolic networks to survive in diverse host environments including mosquitos and humans. Previous studies have revealed many unique genes and metabolites in these organisms, but their biochemical function is not known. This project will use state-of-the-art metabolomics and proteomics technology to accurately identify novel metabolites produced by the parasites, and discover the enzymes that are responsible for their synthesis. This work will not only advance our understanding of cellular metabolism, but will provide new opportunities for future biotechnology applications.Read moreRead less
Improving grain legume seeds for future climates. Grain legumes are essential for sustainable agriculture and human dietary protein, but seed quality is predicted to decline under future scenarios of high CO2 and warmer temperatures. This project aims to improve legume seed quality under future climates by comparing metabolites and physiological traits of chickpea and other legumes to establish mechanisms by which legumes maximise seed nutrient allocation. The anticipated outcomes include new me ....Improving grain legume seeds for future climates. Grain legumes are essential for sustainable agriculture and human dietary protein, but seed quality is predicted to decline under future scenarios of high CO2 and warmer temperatures. This project aims to improve legume seed quality under future climates by comparing metabolites and physiological traits of chickpea and other legumes to establish mechanisms by which legumes maximise seed nutrient allocation. The anticipated outcomes include new metabolite-based breeding markers for the improvement of crops with higher seed proteins, micronutrients and bioactive compounds that are adapted to future climates. Seed nutrient improvement will also include increased biological nitrogen fixation to reduce the need for chemical nitrogen fertilisers.Read moreRead less