Linkage Infrastructure, Equipment And Facilities - Grant ID: LE240100086
Funder
Australian Research Council
Funding Amount
$510,000.00
Summary
Integrated multimodal microscopy facility for single molecule analysis. This project aims to establish an integrated multimodal microscopy facility in Australia for extensive structural characterization of functional and biological materials at the nanoscale and single molecule level. Discoveries using the facility will provide new insights into the relationship between molecules, materials, and their functions. The key outcomes and benefits of this facility are to i) strengthen the research eff ....Integrated multimodal microscopy facility for single molecule analysis. This project aims to establish an integrated multimodal microscopy facility in Australia for extensive structural characterization of functional and biological materials at the nanoscale and single molecule level. Discoveries using the facility will provide new insights into the relationship between molecules, materials, and their functions. The key outcomes and benefits of this facility are to i) strengthen the research effort in materials science and biotechnology, ii) advance the development of functional materials for biosensing and energy storage, and iii) create new catalysts for green energy conversion. The funding will ensure researchers have access to the latest technology critical to maintaining world-class research.Read moreRead less
Discovery and directed evolution of small molecule biosensors. This project aims to address the need for novel small molecule biosensing capability in diverse fields including food and wine production, environmental monitoring, biocatalysis, and diagnostics using a synthetic biology approach. The significance of this work is the development of new biosensors by a strong interdisciplinary team contributing bioinformatics to identify new biosensors, innovative protein engineering approaches, and c ....Discovery and directed evolution of small molecule biosensors. This project aims to address the need for novel small molecule biosensing capability in diverse fields including food and wine production, environmental monitoring, biocatalysis, and diagnostics using a synthetic biology approach. The significance of this work is the development of new biosensors by a strong interdisciplinary team contributing bioinformatics to identify new biosensors, innovative protein engineering approaches, and cutting-edge directed evolution methodologies. Intended outcomes include enhanced institutional capacity for interdisciplinary collaboration; discovery of fundamentally important bacterial sensors; and development of synthetic regulatory circuits enabling outgrowth of non-biological biocatalysis industries.Read moreRead less
Discovery Early Career Researcher Award - Grant ID: DE240100321
Funder
Australian Research Council
Funding Amount
$450,000.00
Summary
Optical Metasurface for Single Small Extracellular Vesicle Analysis. This project aims to develop an innovative nanobiotechnology to study small extracellular vesicles (sEVs) – small biological particles that are important in intercellular communication. The technology will enable unprecedented depth of analysis and single particle resolution. It will generate new knowledge in both engineering and biological sciences by improving sEV image resolution and collecting information regarding the dist ....Optical Metasurface for Single Small Extracellular Vesicle Analysis. This project aims to develop an innovative nanobiotechnology to study small extracellular vesicles (sEVs) – small biological particles that are important in intercellular communication. The technology will enable unprecedented depth of analysis and single particle resolution. It will generate new knowledge in both engineering and biological sciences by improving sEV image resolution and collecting information regarding the distribution of different sEV subpopulations based on their protein phenotypes. Expected outcomes include a universal and ultrasensitive platform with many applications in analytical biochemistry such as disease diagnostics, environmental sciences, food safety and agriculture.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE240100068
Funder
Australian Research Council
Funding Amount
$931,950.00
Summary
Australian Advanced Metabolic Signal Discovery, and Imaging Platform. This proposal aims to establish an Australian Advanced Metabolic Signal Discovery and Imaging platform. The platform consists of an ultra-high resolution gas chromatography mass spectrometer and an imaging mass spectrometry upgrade for a second existing high resolution mass spectrometer. The facility will break barriers currently limiting discovery and localisation of metabolic changes during plant and animal development under ....Australian Advanced Metabolic Signal Discovery, and Imaging Platform. This proposal aims to establish an Australian Advanced Metabolic Signal Discovery and Imaging platform. The platform consists of an ultra-high resolution gas chromatography mass spectrometer and an imaging mass spectrometry upgrade for a second existing high resolution mass spectrometer. The facility will break barriers currently limiting discovery and localisation of metabolic changes during plant and animal development under environmental stress; integral chemical signals exchanged in host-microbe interactions; and volatile signatures linked to ecosystem health and developmental anomalies in animals. Results will inform innovative strategies to enhance biological adaptation, climate resilience and plant, animal, and ecosystem health.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE240100133
Funder
Australian Research Council
Funding Amount
$657,987.00
Summary
An Open Access Native Mass Spectrometry Facility. This project aims to create a world-class Native Mass Spectrometry Facility to allow measurement of proteins, protein complexes and other biomolecules, in a way such that key structural information is maintained. This instrumentation will be the first of its type in Australia allowing measurement of very high mass ions with high precision and accuracy. A better understanding of protein structure will enable new discoveries in chemistry, biotechn ....An Open Access Native Mass Spectrometry Facility. This project aims to create a world-class Native Mass Spectrometry Facility to allow measurement of proteins, protein complexes and other biomolecules, in a way such that key structural information is maintained. This instrumentation will be the first of its type in Australia allowing measurement of very high mass ions with high precision and accuracy. A better understanding of protein structure will enable new discoveries in chemistry, biotechnology and medicinal research. Read moreRead less