Linkage Infrastructure, Equipment And Facilities - Grant ID: LE0989078
Funder
Australian Research Council
Funding Amount
$400,000.00
Summary
Unique, state-of-the-art lipidomics infrastructure. The new technologies provided through this grant will significantly enhance our understanding of lipids and their role in normal cell biology and disease. These new insights will be vital in improving our understanding of lipid-related disorders such obesity, type 2 diabetes and cardiovascular disease and helping to improve their treatment and prevention.
Identifying tear lipids, their deposition onto contact lenses and their role in the development of dry eye. Lipids provide a critical layer in the human tear film that retards evaporation and helps nourish and protect the eye. We will identify the molecules within this essential "oil slick" to better understand dry eye syndrome and the discomfort associated with wearing contact lenses. This may lead to new treatments for dry eye and novel technologies that provide greater comfort for the ~120,00 ....Identifying tear lipids, their deposition onto contact lenses and their role in the development of dry eye. Lipids provide a critical layer in the human tear film that retards evaporation and helps nourish and protect the eye. We will identify the molecules within this essential "oil slick" to better understand dry eye syndrome and the discomfort associated with wearing contact lenses. This may lead to new treatments for dry eye and novel technologies that provide greater comfort for the ~120,000 Australians who wear contact lenses. This collaborative research directly supports the mission of a respected non-profit organisation (Institute for Eye Research) and will train scientists in world-leading analytical technologies that are essential to Australia's emerging biotechnology industries.Read moreRead less
Pulsed oscillating mass analyser. Mass spectrometers are ubiquitous components in chemical analysis, but are often large and expensive. We have developed a new method for mass analysis, which is smaller and cheaper than existing technology. However, the analyser needs further research to determine whether it has the performance specifications to match the other technologies. The objective of this research is to characterise, explore and extend the prototype and to develop the appropriate math ....Pulsed oscillating mass analyser. Mass spectrometers are ubiquitous components in chemical analysis, but are often large and expensive. We have developed a new method for mass analysis, which is smaller and cheaper than existing technology. However, the analyser needs further research to determine whether it has the performance specifications to match the other technologies. The objective of this research is to characterise, explore and extend the prototype and to develop the appropriate mathematical algorithm for mass analysis. Success in this project may lead to a new mass analyser that can be incorporated into analytical instruments, many of which are manufactured in Australia.Read moreRead less
Visualising below the tip of the proteome iceberg. Proteomics attempts to understand human biology by examining the protein components of cells and tissues. Unfortunately, currently available technology only allows approximately 10% of the complexity of these cells and tissues to be concurrently investigated. This project will the physical, chemical and functional properties of protein classes for enrichment, as well as improve technologies for protein visualization, identification and character ....Visualising below the tip of the proteome iceberg. Proteomics attempts to understand human biology by examining the protein components of cells and tissues. Unfortunately, currently available technology only allows approximately 10% of the complexity of these cells and tissues to be concurrently investigated. This project will the physical, chemical and functional properties of protein classes for enrichment, as well as improve technologies for protein visualization, identification and characterization. These approaches will allow the scientific community to further mine beneath the surface of the proteomics 'iceberg'.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE0775650
Funder
Australian Research Council
Funding Amount
$170,000.00
Summary
Advanced multi-purpose analytical pyrolysis facility. Investment by the ARC, two WA universities, a government research agency, a CRC (and idirectly by a water utility) demonstrate the national need for this analytical facility and the broad commitment to maintain Australia's reputation in the field of analytical pyrolysis. An innovative laser micropyrolysis facility will be concurrently used with a recent commercially available unit to support research of present day and palaeo-environmental o ....Advanced multi-purpose analytical pyrolysis facility. Investment by the ARC, two WA universities, a government research agency, a CRC (and idirectly by a water utility) demonstrate the national need for this analytical facility and the broad commitment to maintain Australia's reputation in the field of analytical pyrolysis. An innovative laser micropyrolysis facility will be concurrently used with a recent commercially available unit to support research of present day and palaeo-environmental occurrences of OM, directly assisting an eclectic range of research activities including environmental protection and petroleum exploration. This facility will also aid the chemical fingerprinting of minute forensic evidence, ultimately helping to convict perpetrators of crime.
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Modifying and Improving Porous Sol-Gel Materials for Water Purification. XeroCoat is commercialising nanotechnology research out of UQ's Physics department. XeroCoat has received much local and international interest in its signature product 'XeroCoat'. The company is rapidly expanding and has established new research facilities with production facilities to be set-up. This will result in high technology, employment growth for Australia. Links with Flinders could see expansion into SA. The c ....Modifying and Improving Porous Sol-Gel Materials for Water Purification. XeroCoat is commercialising nanotechnology research out of UQ's Physics department. XeroCoat has received much local and international interest in its signature product 'XeroCoat'. The company is rapidly expanding and has established new research facilities with production facilities to be set-up. This will result in high technology, employment growth for Australia. Links with Flinders could see expansion into SA. The company operates in 'Sol-Gel' nanotechnology, which has huge global, academic and commercial interest. However in Australia this technology has only been serviced by Flinders, ANSTO and ANSTO's spin-out company Ceramisphere. The project will help to build a new Australian high tech industry in sol-gel nanotechnology.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE0454207
Funder
Australian Research Council
Funding Amount
$311,381.00
Summary
New Technology to Fight Crime and Terrorism: Laser Ablation Inductively Coupled Plasma Mass Spectrometer Facilities (LA-ICP-MS). Australia urgently needs new technologies to prevent and fight crime and terrorism. This equipment will address current outstanding problems in forensic science and related disciplines, namely the requirement to (1) analyse minute quantities of samples, (2) differentiate samples with similar matrices but trace differences, (3) analyse solid samples that are difficult t ....New Technology to Fight Crime and Terrorism: Laser Ablation Inductively Coupled Plasma Mass Spectrometer Facilities (LA-ICP-MS). Australia urgently needs new technologies to prevent and fight crime and terrorism. This equipment will address current outstanding problems in forensic science and related disciplines, namely the requirement to (1) analyse minute quantities of samples, (2) differentiate samples with similar matrices but trace differences, (3) analyse solid samples that are difficult to analyse by current techniques. This equipment is also vital for research which will improve the justice system, the quality of food and health products and increase industry competitiveness through novel industrial and environmental testing. Acquiring this infrastructure will safeguard and ensure Australia's continuing prosperity.Read moreRead less
Taxonomic discrimination and compositional analysis of microalgae using Fourier-transform infrared (FT-IR) spectroscopy. The project aims to develop an automated system using infrared spectroscopy that can rapidly and inexpensively identify algae and quantify their chemical composition. The system, which would be based on statistical models developed from infrared spectral information, has the potential to enable rapid identification of blue-green algae at the strain level, allowing new algal bl ....Taxonomic discrimination and compositional analysis of microalgae using Fourier-transform infrared (FT-IR) spectroscopy. The project aims to develop an automated system using infrared spectroscopy that can rapidly and inexpensively identify algae and quantify their chemical composition. The system, which would be based on statistical models developed from infrared spectral information, has the potential to enable rapid identification of blue-green algae at the strain level, allowing new algal blooms to be rapidly compared with those known to be toxic. Compositional analysis using infrared spectroscopy has the potential to measure all major classes of macromolecules simultaneously and precisely, at the single cell level, in a non-destructive manner that does not involve polluting chemicals.Read moreRead less
Isotopic fractionation in ore metals (Cu, Fe and Zn): A new window on ore-forming processes. Stable isotopes of common ore metals (e.g, copper and iron) are new tools for investigating ore deposits. Our data suggest that metal isotopic variations can provide new insights into mechanisms operative during formation of ore deposits. Stable metal isotopes also show promise as a new exploration tool for identifying the location of economic mineralisation within large prospective terrains; e.g., weakl ....Isotopic fractionation in ore metals (Cu, Fe and Zn): A new window on ore-forming processes. Stable isotopes of common ore metals (e.g, copper and iron) are new tools for investigating ore deposits. Our data suggest that metal isotopic variations can provide new insights into mechanisms operative during formation of ore deposits. Stable metal isotopes also show promise as a new exploration tool for identifying the location of economic mineralisation within large prospective terrains; e.g., weakly vs. strongly mineralised zones in a volcanic belt.
This project will provide fundamental baseline data that will help elucidate the processes that cause metal isotope variations. This will allow stable metal isotopes to be used much more effectively by the mining and exploration industries.
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THE FIRST DEVELOPMENT OF MULTI-DIMENSIONAL SPECTRO-ELECTROCHEMISTRY AND ITS APPLICATION TO CRUCIAL TRANSFORMATIONS IN INORGANIC SYSTEMS. Electrolysis is a very widespread and efficient method of chemical synthesis both in industry and research. However, the link between the control voltage and the resultant current is often complicated and easily misinterpreted. To overcome this fundamental problem, we propose an optical spectro-electrochemistry instrument based on a two-dimensional CCD detectio ....THE FIRST DEVELOPMENT OF MULTI-DIMENSIONAL SPECTRO-ELECTROCHEMISTRY AND ITS APPLICATION TO CRUCIAL TRANSFORMATIONS IN INORGANIC SYSTEMS. Electrolysis is a very widespread and efficient method of chemical synthesis both in industry and research. However, the link between the control voltage and the resultant current is often complicated and easily misinterpreted. To overcome this fundamental problem, we propose an optical spectro-electrochemistry instrument based on a two-dimensional CCD detection array. This radically new approach enables simultaneous spectroscopic and spatial data mapping in the realm adjacent to an electrode surface. Important applications range from unequivocal identification of elusive molecules to monitoring metal corrosion. Our first objective is to elucidate certain crucial transformations of mono- and binuclear heavy metal complexes.Read moreRead less