Identifying tear lipids, their deposition onto contact lenses and their role in the development of dry eye. Lipids provide a critical layer in the human tear film that retards evaporation and helps nourish and protect the eye. We will identify the molecules within this essential "oil slick" to better understand dry eye syndrome and the discomfort associated with wearing contact lenses. This may lead to new treatments for dry eye and novel technologies that provide greater comfort for the ~120,00 ....Identifying tear lipids, their deposition onto contact lenses and their role in the development of dry eye. Lipids provide a critical layer in the human tear film that retards evaporation and helps nourish and protect the eye. We will identify the molecules within this essential "oil slick" to better understand dry eye syndrome and the discomfort associated with wearing contact lenses. This may lead to new treatments for dry eye and novel technologies that provide greater comfort for the ~120,000 Australians who wear contact lenses. This collaborative research directly supports the mission of a respected non-profit organisation (Institute for Eye Research) and will train scientists in world-leading analytical technologies that are essential to Australia's emerging biotechnology industries.Read moreRead less
Detection of peptide hormone performance enhancing agents in sport using mass spectrometry. Doping control in sport is to protect the health, legal and ethical rights of athletes. The use of banned drugs in competitive sports is becoming increasingly sophisticated and the need to counter this provides a stimulus for ground breaking analytical research. This project will exploit mass spectrometry for investigation of methods to distinguish administered peptide hormones from endogenous material a ....Detection of peptide hormone performance enhancing agents in sport using mass spectrometry. Doping control in sport is to protect the health, legal and ethical rights of athletes. The use of banned drugs in competitive sports is becoming increasingly sophisticated and the need to counter this provides a stimulus for ground breaking analytical research. This project will exploit mass spectrometry for investigation of methods to distinguish administered peptide hormones from endogenous material and to develop assays for measurement of the peptide hormones, erythropoietin, growth hormone and chorionic gonadotrophin in blood or urine. The outcomes will flow to other areas where trace substance detection is important, such as environmental chemistry, medicine and quality control.Read moreRead less