Examination of unique tear lipids and their role in the tear film's structure and function. The tear film lipid layer covers the eye, stabilises the tears and prevents their evaporation. Yet its structure, function and composition are yet to be fully elucidated. The aim of this project is to fully characterise the unique lipids in this layer, the long-chain omega-hydroxy fatty acids (not found elsewhere in the body), and to determine their role in its structure and function. The project is signi ....Examination of unique tear lipids and their role in the tear film's structure and function. The tear film lipid layer covers the eye, stabilises the tears and prevents their evaporation. Yet its structure, function and composition are yet to be fully elucidated. The aim of this project is to fully characterise the unique lipids in this layer, the long-chain omega-hydroxy fatty acids (not found elsewhere in the body), and to determine their role in its structure and function. The project is significant because the unique combination of skills including synthetic chemistry, mass spectrometry, lipidomics, biochemistry, biophysics which aim to result in a major shift in the understanding of this layer.Read moreRead less
Developing next-generation mass spectrometry imaging with isomer resolution. Mass spectrometry imaging (MSI) is a rapidly emerging technology for mapping molecular distributions within biological samples. This project will bring together market-leading MSI instrumentation from the industry partner Waters Corporation with unique technologies developed at QUT and UOW to develop an integrated MSI-platform capable of achieving high mass- and spatial-resolution, as well as discrimination of lipid iso ....Developing next-generation mass spectrometry imaging with isomer resolution. Mass spectrometry imaging (MSI) is a rapidly emerging technology for mapping molecular distributions within biological samples. This project will bring together market-leading MSI instrumentation from the industry partner Waters Corporation with unique technologies developed at QUT and UOW to develop an integrated MSI-platform capable of achieving high mass- and spatial-resolution, as well as discrimination of lipid isomers. Resolution of lipid isomers using this instrumentation will afford researchers a first glimpse of isomer-resolved images that will be used to visualise tissue-specific changes resulting from underlying chemical, physical or metabolic processes; changes that are currently invisible to contemporary imaging technologies.Read moreRead less
Correction of non-linearity in inductively-coupled-plasma mass-spectrometry. Chemical analyses by mass spectrometers underpin key Australian economic sectors, particularly minerals and agriculture. The quadrupole inductively-coupled-plasma mass-spectrometer has seen a particular rise in prominence over last 25 years. In this collaboration between mass spectrometrists and the leading instrument designer, we will improve the linearity of its detection system for more precise and accurate data. Bet ....Correction of non-linearity in inductively-coupled-plasma mass-spectrometry. Chemical analyses by mass spectrometers underpin key Australian economic sectors, particularly minerals and agriculture. The quadrupole inductively-coupled-plasma mass-spectrometer has seen a particular rise in prominence over last 25 years. In this collaboration between mass spectrometrists and the leading instrument designer, we will improve the linearity of its detection system for more precise and accurate data. Better elemental and isotope ratio data from these high-throughput instruments will open up new real-world applications in many areas of Australian interest, such as biosecurity, forensics, groundwater management, and drug design. The research will also inform design of the next generation instruments by the industry partner.Read moreRead less
Darwin Harbour corals as environmental data archives and bio-monitors. The forecast rapid population growth and industrial development of the Darwin Harbour catchment necessitates research into novel environmental monitoring techniques to aid the sustainable management of the Harbours resources. This project will develop a powerful and cost-effective bio-monitoring system by using chemical data stored in yearly growth bands of coral skeletons stretching back at least two centuries. Such data wil ....Darwin Harbour corals as environmental data archives and bio-monitors. The forecast rapid population growth and industrial development of the Darwin Harbour catchment necessitates research into novel environmental monitoring techniques to aid the sustainable management of the Harbours resources. This project will develop a powerful and cost-effective bio-monitoring system by using chemical data stored in yearly growth bands of coral skeletons stretching back at least two centuries. Such data will form a comparative baseline against which present and future coral data on pollutants released by urban, industrial and other developments can be assessed.Read moreRead less
In-field assessment and lifetime prediction of composite insulators in high voltage electricity transmission networks. New types of composite insulators are now used in extra-high voltage overhead lines in Australia's national electricity grid. Flashover of such insulators due to early ageing may lead to unavailability of vital lines causing power transmission disruptions costing the National Electricity Market tens of millions of dollars.
In this project research will be conducted into agei ....In-field assessment and lifetime prediction of composite insulators in high voltage electricity transmission networks. New types of composite insulators are now used in extra-high voltage overhead lines in Australia's national electricity grid. Flashover of such insulators due to early ageing may lead to unavailability of vital lines causing power transmission disruptions costing the National Electricity Market tens of millions of dollars.
In this project research will be conducted into ageing of elastomers to provide early warning of insulator end-of-life and into new techniques for extracting elastomer samples from live high voltage insulators. Transgrid will cooperate in the application of the technology to give improved understanding of insulator ageing in transmission networks.
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