Special Research Initiatives - Grant ID: SR0354908
Funder
Australian Research Council
Funding Amount
$10,000.00
Summary
The Insect-Plant Chemical Ecology Network (IPCEN). We bring together plant molecular biology, entomology and analytical chemistry to transform three leading fields of Australian research into an advanced science with far reaching capabilities in innovative research and applied outcomes. Expertise studying the biochemical pathways that produce specific plant compounds and expertise in insect recognition and response to these chemicals will be brought together. This will lead to new research outco ....The Insect-Plant Chemical Ecology Network (IPCEN). We bring together plant molecular biology, entomology and analytical chemistry to transform three leading fields of Australian research into an advanced science with far reaching capabilities in innovative research and applied outcomes. Expertise studying the biochemical pathways that produce specific plant compounds and expertise in insect recognition and response to these chemicals will be brought together. This will lead to new research outcomes and solutions to problems in agriculture, horticulture, forestry and protection of Australia's native flora. Researchers are struggling to create these links, constrained by disciplinary boundaries and geographical isolation. Key industries and researchers already support this proposal.Read moreRead less
Imaging Mass Spectrometry (IMS), a peptide biomarker discovery tool using tissue. Cancer is the second most common cause of death in Australia. The newly developed technology of Imaging Mass Spectrometry for peptides in tissue has the potential to discover biomarkers for early diagnosis of cancer. This new technology could avoid a number of cancer deaths and reduce suffering of patients through earlier and better diagnosis.
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE110100174
Funder
Australian Research Council
Funding Amount
$800,000.00
Summary
Innovative synchrotron science - program for access to the Australian National Beamline Facility and cutting-edge beamlines at international synchrotrons. Synchrotron science dramatically affects the community through the innovative scientific, engineering and medical research outcomes it produces. This program for access to synchrotron beamlines is aimed at enhancing Australia's high international standing in synchrotron science and will have many flow-on effects in areas such as health and ind ....Innovative synchrotron science - program for access to the Australian National Beamline Facility and cutting-edge beamlines at international synchrotrons. Synchrotron science dramatically affects the community through the innovative scientific, engineering and medical research outcomes it produces. This program for access to synchrotron beamlines is aimed at enhancing Australia's high international standing in synchrotron science and will have many flow-on effects in areas such as health and industry.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE0882866
Funder
Australian Research Council
Funding Amount
$470,000.00
Summary
MALDI Imaging and Protein Analysis Facility for WA. Mass spectrometry as a tool for analytical research can be coupled to imaging of tissues to provide an important bridge between biochemical, cell biology and physiological sciences. These are competitive research areas that need the latest in speed, accuracy and sensitivity. Strategic placement of such infrastructure in locations of research strength is vital to allow hand-on use that promotes excellence, innovation and creative exploration of ....MALDI Imaging and Protein Analysis Facility for WA. Mass spectrometry as a tool for analytical research can be coupled to imaging of tissues to provide an important bridge between biochemical, cell biology and physiological sciences. These are competitive research areas that need the latest in speed, accuracy and sensitivity. Strategic placement of such infrastructure in locations of research strength is vital to allow hand-on use that promotes excellence, innovation and creative exploration of the limits of such tools to answer pressing questions in biology and chemistry. WA students and researchers will gain new opportunities in an arena of MALDI imaging in biological research and intact protein analysis for structural studies.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE100100125
Funder
Australian Research Council
Funding Amount
$330,000.00
Summary
Oxidative stress bioanalytical facility. The primary national benefit of this application is that it will provide a currently unavailable, state-of-the-art facility for Australian scientists to define precisely how changes in cellular redox state contribute to biological processes relevant to health and diseases. The facility will uniquely complement, and in many cases integrate with existing facilities in this area of research in Australia. It will act as a platform for major national and inter ....Oxidative stress bioanalytical facility. The primary national benefit of this application is that it will provide a currently unavailable, state-of-the-art facility for Australian scientists to define precisely how changes in cellular redox state contribute to biological processes relevant to health and diseases. The facility will uniquely complement, and in many cases integrate with existing facilities in this area of research in Australia. It will act as a platform for major national and international research collaborations, develop cutting-edge technology and unique local skills, and contribute to Australia maintaining a leading position in redox-related research in biology and medicine. In doing so, the facility will increase the likelihood of gaining future, value-adding funding.Read moreRead less
Proteomic techniques to assess oxidative stress in muscle wasting diseases. Australia will experience a significant increase in the proportion of its population that is over 65 years of age over the next 50 years. There will be an increased demand for health services related to injury from falls unless effective preventive strategies are put in place. Loss of muscle mass contributes to falls, so development of preventative strategies has the potential for considerable benefits. Oxidative stress ....Proteomic techniques to assess oxidative stress in muscle wasting diseases. Australia will experience a significant increase in the proportion of its population that is over 65 years of age over the next 50 years. There will be an increased demand for health services related to injury from falls unless effective preventive strategies are put in place. Loss of muscle mass contributes to falls, so development of preventative strategies has the potential for considerable benefits. Oxidative stress is a key intermediary in muscle wasting. This PhD project examines a possible mechanism by which oxidative stress causes muscle wasting. An appropriately tailored therapy to minimise oxidative stress has the potential to ameliorate loss of muscle mass.
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A proteomic approach to identifying the signaling pathway(s) by which acute oxidative stress causes cell death by apoptosis. Oxidative stress following traumatic injury (heart attack or stroke) is known to activate signaling pathways leading to programmed cell death (apoptosis). The aim of this project is to develop methods to identify the signaling proteins involved. Identifying proteins involved in causing cell death will be useful in developing diagnostic tools as well as providing potential ....A proteomic approach to identifying the signaling pathway(s) by which acute oxidative stress causes cell death by apoptosis. Oxidative stress following traumatic injury (heart attack or stroke) is known to activate signaling pathways leading to programmed cell death (apoptosis). The aim of this project is to develop methods to identify the signaling proteins involved. Identifying proteins involved in causing cell death will be useful in developing diagnostic tools as well as providing potential therapeutic possibilities.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE0882913
Funder
Australian Research Council
Funding Amount
$300,000.00
Summary
Mass spectrometry facility for the quantitation and analysis of post-translationally modified peptides. This proposal will address a gap in our mass spectrometry capabilities and aid in our understanding of the cellular immune response and investigate the chemical diversity of the targets of immunity. This proposal has broad implications in the basic immunology of antigen presentation, in biomarker discovery as well as in the design of new vaccines in infectious disease and cancer and the develo ....Mass spectrometry facility for the quantitation and analysis of post-translationally modified peptides. This proposal will address a gap in our mass spectrometry capabilities and aid in our understanding of the cellular immune response and investigate the chemical diversity of the targets of immunity. This proposal has broad implications in the basic immunology of antigen presentation, in biomarker discovery as well as in the design of new vaccines in infectious disease and cancer and the development of therapies for autoimmune diseases. In addition to these key scientific outcomes this project will also facilitate the training of several new personnel in a skill area for which there is a critical shortage (mass spectrometry) and promote cross-disciplinary skills (immunology, biochemistry, proteomics).Read moreRead less
Proteome mapping of the model fungal plant pathogen Stagonospora nodorum using LC-LC-MS/MS. Stagonospora nodorum is a fungus that causes leaf and glume blotch disease on wheat. This disease alone causes $55 million dollars in yield losses per annum in Australia. This project aims to identify the proteins produced by Stagonospora nodorum through the development of a new proteomics technique. Two clear benefits to the community resulting from this project will emerge. The first will be the expert ....Proteome mapping of the model fungal plant pathogen Stagonospora nodorum using LC-LC-MS/MS. Stagonospora nodorum is a fungus that causes leaf and glume blotch disease on wheat. This disease alone causes $55 million dollars in yield losses per annum in Australia. This project aims to identify the proteins produced by Stagonospora nodorum through the development of a new proteomics technique. Two clear benefits to the community resulting from this project will emerge. The first will be the expert training of a student in proteomics, a skill that is keenly sought. Secondly, the identification of these pathogen proteins will lead to new strategies to better control the disease and secure the supply of wheat.Read moreRead less
Discovery Early Career Researcher Award - Grant ID: DE180100080
Funder
Australian Research Council
Funding Amount
$365,058.00
Summary
Examining lipid transport by direct visualisation and quantification. This project aims to investigate the least understood aspect of plasma triglyceride metabolism; mechanisms of transport across capillary endothelial cells. This transport regulates plasma triglyceride levels, which are an important factor in determining risk for coronary diseases. An improved understanding of these mechanisms will lead in the long term to better understandings of both heart failure and atherosclerotic heart di ....Examining lipid transport by direct visualisation and quantification. This project aims to investigate the least understood aspect of plasma triglyceride metabolism; mechanisms of transport across capillary endothelial cells. This transport regulates plasma triglyceride levels, which are an important factor in determining risk for coronary diseases. An improved understanding of these mechanisms will lead in the long term to better understandings of both heart failure and atherosclerotic heart diseases.Read moreRead less