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Enhancing our understanding of metallochemistry in neurobiology with modern electron paramagnetic resonance (EPR) spectroscopy. Many neurological diseases involve protein accumulation that appears causally linked to abnormal levels of metal ions in the brain. This project will use a special technique called electron paramagnetic resonance to uncover how these metals interact with specific proteins at the molecular level and how drug treatments can modify these interactions.
Quantification of whole brain structural connectivity and fibre densities. The project is intended to develop and improve accuracy in tools used to measure brain connections. Its overall aim is to produce definitive evidence of the biological accuracy of quantitative measures of brain structural connectivity as derived from diffusion magnetic resonance imaging (MRI). Discovery in the quantitative field of MRI research is important to worldwide efforts to identify the human ‘connectome’. The proj ....Quantification of whole brain structural connectivity and fibre densities. The project is intended to develop and improve accuracy in tools used to measure brain connections. Its overall aim is to produce definitive evidence of the biological accuracy of quantitative measures of brain structural connectivity as derived from diffusion magnetic resonance imaging (MRI). Discovery in the quantitative field of MRI research is important to worldwide efforts to identify the human ‘connectome’. The project plans to bring together novel diffusion MRI post-processing methods and state-of-the-art 3-D glass-brain histology techniques using mice. Investment in MRI research that specifically addresses methods to accurately measure structural brain connectivity may ultimately contribute to improving non-invasive imaging methods.Read moreRead less
Neural Control Of Behavioural State And Cognition - Role Of Nucleus Incertus And Relaxin-3
Funder
National Health and Medical Research Council
Funding Amount
$600,771.00
Summary
Dementia and mental illness are significant social and economic burdens worldwide and knowledge of underlying causes and more effective therapies are required. Our research is using preclinical models to characterize a little studied neural network in the control of arousal states, rhythmic brain activity, and learning and memory. Our findings could advance the development of improved treatments for cognitive deficits in degenerative, age-related and psychiatric disorders.
Special Research Initiatives - Grant ID: SR120300015
Funder
Australian Research Council
Funding Amount
$16,000,000.00
Summary
The Science of Learning Research Centre. In this innovative new Centre, researchers in education, neuroscience and cognitive psychology will work together with teachers to understand the learning process. This collaboration will establish new criteria to assess the impact of different types of learning and strategies to inform teaching practices of benefit to all Australians.
Discovery Early Career Researcher Award - Grant ID: DE120101311
Funder
Australian Research Council
Funding Amount
$375,000.00
Summary
Role of intrinsic versus extrinsic cues in cell type determination during development and regeneration. During development all of the different cell types are generated by the action of genes and also signals from the embryo that read out which cell types are present or missing. This project studies how much environmental signals affect cell type generation developmentally and if they can be used to regenerate only the types missing in different diseases.
Computational neuroanatomy: analysis of neural connections in the primate brain. This project will map the full network of connections between brain cells, using a computer graphics database that will consolidate data from hundreds of experiments. This will allow the first realistic simulations of neural activity, and will provide new insights about the structure and function of the nervous system.
The processing of sensory information within cortical circuits. This project aims to improve our knowledge of neuronal activity during sensory perception and therefore shed light on overall brain function during behaviour. Understanding how dendrites receive and process this information is crucial to understanding brain function during sensory processing and perception. This proposal aims to characterise dendritic activity during sensory input and discover how this activity contributes to behavi ....The processing of sensory information within cortical circuits. This project aims to improve our knowledge of neuronal activity during sensory perception and therefore shed light on overall brain function during behaviour. Understanding how dendrites receive and process this information is crucial to understanding brain function during sensory processing and perception. This proposal aims to characterise dendritic activity during sensory input and discover how this activity contributes to behavioural tasks. In particular, the project plans to investigate activity of different dendritic domains during sensory perception and sensory-based behaviour. The project seeks to improve our knowledge of the importance of dendrites in transforming information from the sensory environment and highlight the cellular and network mechanisms contributing to behaviour.Read moreRead less
Identifying genes that influence clinical course and susceptibility in multiple sclerosis. This project aims to identify the genetic basis of multiple sclerosis (MS), the most common neurologic disease in young Australian adults. MS urgently needs research to identify predisposition, aid early diagnosis and provide bona fide molecular targets for new therapies. This will benefit people with MS and those susceptible to it. Crucial new knowledge identified will benefit other major areas of MS rese ....Identifying genes that influence clinical course and susceptibility in multiple sclerosis. This project aims to identify the genetic basis of multiple sclerosis (MS), the most common neurologic disease in young Australian adults. MS urgently needs research to identify predisposition, aid early diagnosis and provide bona fide molecular targets for new therapies. This will benefit people with MS and those susceptible to it. Crucial new knowledge identified will benefit other major areas of MS research including epidemiology, immunology and neurobiology. Collaboration of 8 major Australian institutions is also important for this project and future studies. The team will have access to a new national MS GeneBank (platform) with samples from 2240 patients that should generate findings important to world-wide MS genetic knowledge.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE0668246
Funder
Australian Research Council
Funding Amount
$400,000.00
Summary
Advanced Cell Labelling and Imaging Facility. Understanding the genetic regulation of cellular processes such as migration, differentiation and growth is an important frontier technology with significant biomedical potential. The Australian community is facing an increasing need to provide solutions for a variety of human diseases and disorders, including birth defects, nervous system injury and stroke, and ageing-related conditions. The proposed facility will allow researchers to test in vivo g ....Advanced Cell Labelling and Imaging Facility. Understanding the genetic regulation of cellular processes such as migration, differentiation and growth is an important frontier technology with significant biomedical potential. The Australian community is facing an increasing need to provide solutions for a variety of human diseases and disorders, including birth defects, nervous system injury and stroke, and ageing-related conditions. The proposed facility will allow researchers to test in vivo gene/pharmaceutical therapies as well as to better understand the genetic regulation of normal cellular processes. Read moreRead less
Molecular neurobiology of the GABAB receptor: Studies of heteromeric receptor function and signalling. The G protein-coupled receptor (GPCR) for the inhibitory transmitter gamma- aminobutyric acid (GABA) is a unique heterodimer. Molecular analyses will be undertaken to provide insights into its signalling mechanisms and functional regulation. Investigations employing point mutant and chimeric receptors will analyse how ligand binding to the extracellular domain of the GABA-BR1 subunit triggers ....Molecular neurobiology of the GABAB receptor: Studies of heteromeric receptor function and signalling. The G protein-coupled receptor (GPCR) for the inhibitory transmitter gamma- aminobutyric acid (GABA) is a unique heterodimer. Molecular analyses will be undertaken to provide insights into its signalling mechanisms and functional regulation. Investigations employing point mutant and chimeric receptors will analyse how ligand binding to the extracellular domain of the GABA-BR1 subunit triggers G protein-coupling to the intracellular portion of the GABA-BR2 subunit. Focus will be on different modes of GPCR signalling, including constitutive activity and roles for membrane and cytosolic regulatory proteins. Targeted studies of GABAB receptor subunits will provide new information on the mechanistic regulation of GPCR signalling.Read moreRead less