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Non-medical use of prescription stimulants by Australian university students: attitudes, prevalence of, and motivations for use. This study will provide a comprehensive understanding of student non-medical use of prescription stimulants. The findings will inform initiatives to prevent the abuse and misuse of pharmaceuticals, protect health and reduce the cost associated with inappropriate use of medicines.
Cannabis and the brain: the good, the bad and the unknown. Cannabis is the most widely used illicit drug but much remains unknown about how it affects the brain. This research will examine effects on brain cells through to whole brain function in humans to determine how cannabis use may lead to impaired thinking or psychological symptoms and why cannabis might affect individuals in different ways.
Discovery Early Career Researcher Award - Grant ID: DE170100509
Funder
Australian Research Council
Funding Amount
$388,000.00
Summary
Molecular mechanisms causing relapse. This project aims to identify the neural connectivity and molecular profile of ventral pallidal neurons in the brain that control drug and alcohol addiction, relapsing disorders where users lose the ability to inhibit drug seeking behaviour. This project integrates neurobiological and psychological attributes of relapse. The anticipated outcomes provide insights about molecular mechanisms causing relapse, and expand knowledge of brain mechanisms that contrib ....Molecular mechanisms causing relapse. This project aims to identify the neural connectivity and molecular profile of ventral pallidal neurons in the brain that control drug and alcohol addiction, relapsing disorders where users lose the ability to inhibit drug seeking behaviour. This project integrates neurobiological and psychological attributes of relapse. The anticipated outcomes provide insights about molecular mechanisms causing relapse, and expand knowledge of brain mechanisms that contribute to relapsing disorders such as drug addiction and obesity. The findings from this project could be used to reduce relapse, and hence reduce the burden of alcohol related problems on health, the community and the Australian economy.Read moreRead less
When is extinction not extinction? Disorders of fear and anxiety are widespread and impose significant burdens on individual sufferers and their families. This projects studies new ways of augmenting loss of fear and will identify the important behavioural mechanisms as well as critical brain pathways for this fear loss.
The role of reward expectancy and reward availability in appetitive motivation. This project will investigate the learning processes that help regulate our desire for rewards such as food and drugs and our decisions about when to pursue those rewards. The results will have implications for our understanding of normal reward motivation as well as interventions for maladaptive behaviours such as gambling and drug-taking.
Uncertainty and response control in the prefrontal cortex. This project will identify how complex behaviours come to be performed habitually. It is proposed that statistical certainty in the learning environment is a key determinant of automatic behaviour, that detection of uncertainty can restore voluntary control of behaviour and that this is an important function of the prefrontal cortex of the brain.