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A New Platform for Developing a Compound Against Herpes Simplex Virus. This project aims to further explore the research team’s recent fundamental discovery of a protein found naturally in an Australian abalone that inhibits viral entry by blocking three key viral glycoproteins. We would aim to utilise this knowledge towards development of a new class of therapeutics against Herpes simplex viruses (HSV) and their consequent infections. The new therapeutics could overcome the low bioavailability ....A New Platform for Developing a Compound Against Herpes Simplex Virus. This project aims to further explore the research team’s recent fundamental discovery of a protein found naturally in an Australian abalone that inhibits viral entry by blocking three key viral glycoproteins. We would aim to utilise this knowledge towards development of a new class of therapeutics against Herpes simplex viruses (HSV) and their consequent infections. The new therapeutics could overcome the low bioavailability of current drugs and thus significantly shorten the recurrence period. Such new drugs may have broad applicability.Read moreRead less
Developing a chlamydial vaccine for koalas. Developing a chlamydial vaccine for koalas . This project aims to produce an optimised, safe, field-tested, protective Chlamydia vaccine for koalas. In many regions of Australia, Chlamydia infection severely reduces female koala reproductive rates, threatening the species’ long term survival. This project builds on work developing a prototype vaccine for koala Chlamydia, and intends to produce a vaccine ready for potential registration and use by koala ....Developing a chlamydial vaccine for koalas. Developing a chlamydial vaccine for koalas . This project aims to produce an optimised, safe, field-tested, protective Chlamydia vaccine for koalas. In many regions of Australia, Chlamydia infection severely reduces female koala reproductive rates, threatening the species’ long term survival. This project builds on work developing a prototype vaccine for koala Chlamydia, and intends to produce a vaccine ready for potential registration and use by koala care centres, wildlife hospitals and government departments.Read moreRead less
Development of new tools for surveillance of chlamydial infections in sheep. This project aims to improve health in sheep and reduce on-farm losses for Australian producers, by developing new serological tests for chlamydial infections in sheep. These infections can result in significant on-farm losses and loss of trade in the live export industry. Currently, surveillance of chlamydial infections is hindered by outdated serological tools that are unreliable and difficult to interpret. The ser ....Development of new tools for surveillance of chlamydial infections in sheep. This project aims to improve health in sheep and reduce on-farm losses for Australian producers, by developing new serological tests for chlamydial infections in sheep. These infections can result in significant on-farm losses and loss of trade in the live export industry. Currently, surveillance of chlamydial infections is hindered by outdated serological tools that are unreliable and difficult to interpret. The serological tests to be developed aim to be species-specific tests to detect the most important chlamydial sheep pathogens. This in turn endeavours to improve domestic surveillance, reducing on-farm losses and costs, and improve market opportunities for Australian sheep exporters as well as informing veterinary populations on best practice treatment.Read moreRead less
Improving the diagnosis, management and control of chlamydial infections in Australian livestock. Chlamydial diseases, such as arthritis and encephalomyelitis, are associated with significant economic losses for Australian livestock producers. Effective surveillance and management of Chlamydia infections is problematic due to: the absence of epidemiological data; the lack of an accurate and easily interpretable diagnostic test; and the lack of an available vaccine. This project aims to evaluate ....Improving the diagnosis, management and control of chlamydial infections in Australian livestock. Chlamydial diseases, such as arthritis and encephalomyelitis, are associated with significant economic losses for Australian livestock producers. Effective surveillance and management of Chlamydia infections is problematic due to: the absence of epidemiological data; the lack of an accurate and easily interpretable diagnostic test; and the lack of an available vaccine. This project aims to evaluate factors associated with chlamydial disease in Australian livestock and thereby improve on-farm diagnosis. With the concomitant development of a chlamydial vaccine for sheep, this project aims to provide veterinarians and producers with important tools to reduce the on-farm impacts of chlamydial disease.Read moreRead less
Resolving human-flying fox conflict in the face of environmental change. Resolving human-flying fox conflict in the face of environmental change. This project aims to identify socially-acceptable priority areas to be managed for the long-term viability of flying-foxes under a changing climate, and develop strategies to mitigate human-flying fox conflict, using ecological and social analysis in a decision-theoretic framework. Flying-foxes are nationally protected mammals pivotal to Australia’s fo ....Resolving human-flying fox conflict in the face of environmental change. Resolving human-flying fox conflict in the face of environmental change. This project aims to identify socially-acceptable priority areas to be managed for the long-term viability of flying-foxes under a changing climate, and develop strategies to mitigate human-flying fox conflict, using ecological and social analysis in a decision-theoretic framework. Flying-foxes are nationally protected mammals pivotal to Australia’s forest ecosystems, but are threatened by habitat loss, extreme weather and legal culls at orchards. Their exceptional mobility puts them in frequent conflict with human settlements, leading to forced dispersals from roosts. Anticipated outcomes are the conservation of Australia’s flying-foxes and international understanding of how to resolve human conflict with highly mobile species that are threatened but locally abundant and controversial.Read moreRead less
Towards a Legal and Institutional Framework for the Conservation and Sustainable Use of High Seas Biodiversity. The legal and institutional challenges required to manage high seas biodiversity have been identified by the United Nations as one of the greatest challenges in oceans management in the 21st century. This Project will research the legal and institutional factors at the national, regional and international levels that militate against conservation of marine biodiversity beyond nation ....Towards a Legal and Institutional Framework for the Conservation and Sustainable Use of High Seas Biodiversity. The legal and institutional challenges required to manage high seas biodiversity have been identified by the United Nations as one of the greatest challenges in oceans management in the 21st century. This Project will research the legal and institutional factors at the national, regional and international levels that militate against conservation of marine biodiversity beyond national jurisdictions and develop practical actions to address the problems identified. The outcome of the Project will be the development of a policy oriented methodology to guide the legal and policy developments on high seas biodiversity conservation at the international and national levels.Read moreRead less
The Lively Regional City: Mapping City Centre ‘Assemblages’ that Work. This project analyses city centre revitalisation processes and policies in the context of regional Australia. Working with Wollongong City Council, the project aims to provide an evidence-based analysis of how the Wollongong city centre is perceived, regarded and used by its residents and visitors, paying particular attention to those aspects considered either 'lively' or 'dead'; its goal is to interrogate revitalisation poli ....The Lively Regional City: Mapping City Centre ‘Assemblages’ that Work. This project analyses city centre revitalisation processes and policies in the context of regional Australia. Working with Wollongong City Council, the project aims to provide an evidence-based analysis of how the Wollongong city centre is perceived, regarded and used by its residents and visitors, paying particular attention to those aspects considered either 'lively' or 'dead'; its goal is to interrogate revitalisation policy frameworks and create decision-making tools to inform planning processes for long-term city centre revitalisation and sustainable economic growth; and identify opportunities for innovative city centre planning in Wollongong to contribute to the regions sustainable transformation, long-term growth, employment and community development.Read moreRead less
Predicting the diagnostic performance of individuals and organisations. Predicting the diagnostic performance of individuals and organisations. This project aims to address diagnostic error in advanced technology systems, by providing a mechanism to assess and improve individual diagnosticians’ performance. Organisations that rely on their employees’ diagnostic skills rarely assess them once the operators become qualified, so there is no basis for interventions that might prevent diagnostic erro ....Predicting the diagnostic performance of individuals and organisations. Predicting the diagnostic performance of individuals and organisations. This project aims to address diagnostic error in advanced technology systems, by providing a mechanism to assess and improve individual diagnosticians’ performance. Organisations that rely on their employees’ diagnostic skills rarely assess them once the operators become qualified, so there is no basis for interventions that might prevent diagnostic errors affecting thousands. This research tests a new method of assessing diagnostic skills based on how skilled operators respond to cues. This project will test how employees’ diagnostic skills change and whether this change corresponds to measures of organisational performance. This research is expected to provide organisations with a tool to pre-empt diagnostic errors that could minimise costs to the economy.Read moreRead less
Providing the Mathematical Foundation for an Innovative Australia within Reform Based Learning Environments. The focus of this project is the pedagogical change that The Review of Teaching and Teacher Education indicates must take place in order to lay the quantitative foundations for advancing innovation, science, technology, and mathematics, while satisfying the requirements of a reform-based learning environment. Professional learning directed at teachers' pedagogical content knowledge and be ....Providing the Mathematical Foundation for an Innovative Australia within Reform Based Learning Environments. The focus of this project is the pedagogical change that The Review of Teaching and Teacher Education indicates must take place in order to lay the quantitative foundations for advancing innovation, science, technology, and mathematics, while satisfying the requirements of a reform-based learning environment. Professional learning directed at teachers' pedagogical content knowledge and belief structures with respect to mathematics within an environment of curricular change, will be evaluated in evidence-based terms related to teacher change and student outcomes. Significance includes the context, the middle school years in rural district schools, and the influence of technology on pedagogy.Read moreRead less
Estimating per capita use and release of chemicals by wastewater analysis. This project aims to systematically collect and analyse wastewater to assess human exposure to chemicals including drugs, pharmaceuticals, lifestyle chemicals and environmental pollutants. By combining temporal sampling from key sewage treatment plants with comprehensive nationwide sampling over the week of the 2016 census day, the project expects to estimate the per-capita human exposure to chemicals in the Australian po ....Estimating per capita use and release of chemicals by wastewater analysis. This project aims to systematically collect and analyse wastewater to assess human exposure to chemicals including drugs, pharmaceuticals, lifestyle chemicals and environmental pollutants. By combining temporal sampling from key sewage treatment plants with comprehensive nationwide sampling over the week of the 2016 census day, the project expects to estimate the per-capita human exposure to chemicals in the Australian population. Accurate and objective per-capita based consumption and release estimates for a wide range of chemicals is intended to provide a baseline against which to measure changes in our chemosphere.Read moreRead less