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Self-assembly and complexity: networks and patterns from materials to markets. Self-assembly leads the formation of patterns without external directing agents. It is responsible for the growth of complex multiscale structures found in biology and materials science and is a crucial concept for development of viable nanotechnologies. Complex systems, from biological ecosystems to financial markets and the Internet, are also characterized by spontaneous clustering and linkages that determine their ....Self-assembly and complexity: networks and patterns from materials to markets. Self-assembly leads the formation of patterns without external directing agents. It is responsible for the growth of complex multiscale structures found in biology and materials science and is a crucial concept for development of viable nanotechnologies. Complex systems, from biological ecosystems to financial markets and the Internet, are also characterized by spontaneous clustering and linkages that determine their collective behaviour. The project will investigate in detail the geometry, topology, materials science and statistical physics of networks, leading to design and characterization of robust self-assembled materials and complex systems.Read moreRead less
Energy Conversion and Signal Transduction in Nanomechanical Systems. Miniaturization of materials and electronic devices is an important technological goal. In order to make smaller working devices,we need to understand how to create molecular scale devices such as valves, switches, pumps and motors. This Fellowship will explore ways to make smaller, portable devices that can be used for personal health monitoring,environmental sensing and the detection of disease and pathogens.
Separation science based on nanoparticle-coated monolithic scaffold stationary phases. The proposed project will generate highly significant, fundamental advances in separation science by developing new stationary phases and separation technologies suitable for the analysis of very complex samples which cannot be addressed by current methods. These technologies will be applied in a wide range of areas of national importance including pre-and post-blast identification of explosives in counter-ter ....Separation science based on nanoparticle-coated monolithic scaffold stationary phases. The proposed project will generate highly significant, fundamental advances in separation science by developing new stationary phases and separation technologies suitable for the analysis of very complex samples which cannot be addressed by current methods. These technologies will be applied in a wide range of areas of national importance including pre-and post-blast identification of explosives in counter-terrorism applications; environmental, clinical, and forensic analysis; energy generation and foods. The project will also lead to very significant new intellectual property having extremely high commercial potential worldwide, and thereby generates the promise of considerable direct financial returns to Australia.Read moreRead less
Self organization in (bio)molecular systems: Simulating the folding and aggregation of peptides, proteins and lipids. Molecular self-assembly is a basic property of living systems. Most proteins fold spontaneously and then further self-organize into functional complexes, effectively biological machines. Understanding how this occurs is a fundamental theoretical challenge with widespread application. Work will focus on developing methodology to simulate, computationally, the folding and aggrega ....Self organization in (bio)molecular systems: Simulating the folding and aggregation of peptides, proteins and lipids. Molecular self-assembly is a basic property of living systems. Most proteins fold spontaneously and then further self-organize into functional complexes, effectively biological machines. Understanding how this occurs is a fundamental theoretical challenge with widespread application. Work will focus on developing methodology to simulate, computationally, the folding and aggregation of peptides, proteins, and lipids. The aim is to accurately predict the structures of small peptides in solution and to refine crude models of larger molecules (complexes). This will facilitate the development of peptide based therapeutics and is essential in exploiting the growing volume of genetic information in biology and medicine.Read moreRead less
Molecular Mechanisms of Biochemical Regulation: Neutron and X-ray Scattering Studies. This project will develop and use novel neutron and x-ray scattering methods to study the molecular mechanisms by which nature regulates biochemical processes. Healthy function requires cells to tightly control and coordinate a myriad of molecular activities. My research focuses on a set of interdependent molecular networks inside cells whose behavior is controlled by the so-called 'second messengers' that tr ....Molecular Mechanisms of Biochemical Regulation: Neutron and X-ray Scattering Studies. This project will develop and use novel neutron and x-ray scattering methods to study the molecular mechanisms by which nature regulates biochemical processes. Healthy function requires cells to tightly control and coordinate a myriad of molecular activities. My research focuses on a set of interdependent molecular networks inside cells whose behavior is controlled by the so-called 'second messengers' that translate external signals into the right cellular responses. The proposed experiments will provide a unique structural framework by which we can understand how these signals are transmitted. Such knowledge is an important foundation for advances in biomedical research and biotechnology applications.Read moreRead less
New Methods for Structural Biology in Solution. It is proposed to establish a new research group that focuses on the development of new nuclear magnetic resonance (NMR) technologies and applications to problems concerning protein structure and function. This includes
- the exploitation of new NMR parameters;
- optimization of an inexpensive in vitro protein expression system;
- development of experimental strategies for the identification of protein-ligand surfaces by chemical modificatio ....New Methods for Structural Biology in Solution. It is proposed to establish a new research group that focuses on the development of new nuclear magnetic resonance (NMR) technologies and applications to problems concerning protein structure and function. This includes
- the exploitation of new NMR parameters;
- optimization of an inexpensive in vitro protein expression system;
- development of experimental strategies for the identification of protein-ligand surfaces by chemical modification, as a basis for high-throughput mass spectrometrical analyses;
- development of an algorithm for rapid resonance assignment of 15N-labelled proteins which is of importance for the pharmaceutical industry;
- 3D structure determinations of proteins and protein domains.Read moreRead less
Integration of Electrochemistry and Green Chemistry: A Roadmap for Scientific Innovation. Electrochemistry represents an enabling science in physical, chemical and life sciences. It plays a key role in fundamental studies and in Australia's industrial capacity to exploit emerging technologies. Research conducted synergistically within the ARC Centre for Green Chemistry would enable the Monash Electrochemistry Group to develop and exploit new concepts. In the national interest, the Fellowship ....Integration of Electrochemistry and Green Chemistry: A Roadmap for Scientific Innovation. Electrochemistry represents an enabling science in physical, chemical and life sciences. It plays a key role in fundamental studies and in Australia's industrial capacity to exploit emerging technologies. Research conducted synergistically within the ARC Centre for Green Chemistry would enable the Monash Electrochemistry Group to develop and exploit new concepts. In the national interest, the Fellowship would: facilitate global participation in cutting-edge science derived from electrochemical and green chemical concepts; provide commercial opportunities for new and mature chemical industries; expand postgraduate training; and promote technology exchange with Australian and international leading-edge research organisations.Read moreRead less
Building Molecularly Engineered Polymer Nanomaterials. The development of new technologies at the interface between nano- and biotechnology promises to revolutionise healthcare and medicine. This research program will involve the design and synthesis of responsive and programmable polymers and their assembly to form next-generation, engineered materials. The nanomaterials prepared are expected to lead to the development of techniques that enable new types of minimally invasive diagnostics and th ....Building Molecularly Engineered Polymer Nanomaterials. The development of new technologies at the interface between nano- and biotechnology promises to revolutionise healthcare and medicine. This research program will involve the design and synthesis of responsive and programmable polymers and their assembly to form next-generation, engineered materials. The nanomaterials prepared are expected to lead to the development of techniques that enable new types of minimally invasive diagnostics and therapeutics as well as smaller devices. The interdisciplinary research program will cement Australia's position as a leading country in nanobiotechnology research and development.Read moreRead less
Application of First-principles Theory in Condensed Matter Physics, Surface Physics, Chemistry, and Engineering: Coatings, Catalysis, and Devices. The project addresses areas of high technological interest, namely the development of nitride-based materials for hard-coatings, spintronic (control and use of electron spin) and optoelectronic (in the blue/UV energy range) devices - as well as the area of heterogeneous oxidation catalysis. Using state-of-the-art methods it will lead to the developme ....Application of First-principles Theory in Condensed Matter Physics, Surface Physics, Chemistry, and Engineering: Coatings, Catalysis, and Devices. The project addresses areas of high technological interest, namely the development of nitride-based materials for hard-coatings, spintronic (control and use of electron spin) and optoelectronic (in the blue/UV energy range) devices - as well as the area of heterogeneous oxidation catalysis. Using state-of-the-art methods it will lead to the development of new materials and devices of relevance to industry.Read moreRead less
Structural and Biological Chemistry of Marine Natural Products. Australia's unique marine biodiversity provides a source of novel biologically active compounds with potential for development as pharmaceuticals. This program seeks to explore the structural and biological chemistry of novel marine compounds from marine invertebrates and to evaluate their potential benefit is training of scientists in organic and biological chemistry and advancement of drug-discovery from Australian biodiversity.