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Innovative Antimicrobial Treatments For Successful Bone Allografts
Funder
National Health and Medical Research Council
Funding Amount
$473,706.00
Summary
Bone healing sites are commonly infected, and this is associated with adverse clinical and significant socioeconomic outcomes. These studies will determine whether our novel antimicrobials can be used to reduce bone infections by studying the combination of antimicrobials and bone in laboratory and bone fracture studies whilst minimising the potential of developing antibiotic resistance.
Bioactive And Biodegradable Scaffold And Novel Graft Source For The Repair Of Large Segmental Bone Defects
Funder
National Health and Medical Research Council
Funding Amount
$451,103.00
Summary
The treatment of large bone defects arising from trauma and tumour remains a challenge to orthopaedic surgeons. This project combines a well-established scaffold that can be custom-made to address patient specific requirements with a novel source of graft that can be harvested in significant volumes with minimal pain and morbidity. This novel tissue engineering approach will be evaluated in a previously established pre-clinical model that reflects the severity of challenging clinical scenarios.
Biocompatible Synthetic Conduits To Treat Vascular Disease
Funder
National Health and Medical Research Council
Funding Amount
$421,818.00
Summary
Clinically available synthetic conduits used in vascular repair and bypass are fundamentally incompatible with the vasculature. They cause inflammation at the site of implantation and increase the risk of blood clots forming. We have developed a unique method of binding bioactive protein layers to the surface of all polymeric materials and have shown a significant improvement in their compatibility. Grafts coated using our technology stand to dramatically improve the treatment of vascular diseas ....Clinically available synthetic conduits used in vascular repair and bypass are fundamentally incompatible with the vasculature. They cause inflammation at the site of implantation and increase the risk of blood clots forming. We have developed a unique method of binding bioactive protein layers to the surface of all polymeric materials and have shown a significant improvement in their compatibility. Grafts coated using our technology stand to dramatically improve the treatment of vascular disease.Read moreRead less
Biothermosetting Bone Filler: An Injectable Osteoconductive Repair Material
Funder
National Health and Medical Research Council
Funding Amount
$601,698.00
Summary
Bone injury is a common and profoundly debilitating issue, and is responsible for extended partial or complete loss of mobility and associated economic impact during slow healing. There is strong demand for technology that reduces the time taken for bone repair. There is still a paucity of clinically effective biocompatible materials for treatment. We have developed a novel approach for a thermoresponsive hydrogel with unique properties suitable for rapid bone filling and regeneration.
Development Of Endovascular Stents With Proactive Biocompatibility
Funder
National Health and Medical Research Council
Funding Amount
$428,470.00
Summary
Metallic cardiovascular implants, such as stents, used in the treatment of heart disease are not compatible with blood. They cause inflammation at the site of implantation and increase the risk of blood clots forming. We have developed a unique method of binding bioactive protein layers to the surface of metal alloys, and shown a significant improvement in their compatibility. Stents coated using our technology stand to dramatically improve the treatment of cardiovascular disease.