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Visualising molecular level detail in single cells and intact tissues. The goal of this project is to deliver a new toolkit for imaging cells at an unprecedented resolution and level of chemical detail. We will expand the capabilities of two existing, but complementary, methods: optical fluorescence microscopy with responsive probes and X-ray fluorescence imaging. Expected outcomes include improved techniques and benchmarks for visualising bacterial and mammalian cells; development of new molecu ....Visualising molecular level detail in single cells and intact tissues. The goal of this project is to deliver a new toolkit for imaging cells at an unprecedented resolution and level of chemical detail. We will expand the capabilities of two existing, but complementary, methods: optical fluorescence microscopy with responsive probes and X-ray fluorescence imaging. Expected outcomes include improved techniques and benchmarks for visualising bacterial and mammalian cells; development of new molecules for elucidating cellular chemistry; better utilisation of valuable synchrotron resources; and greater understanding of the strengths and limitations of current microscopy workflows. Results should benefit the biotechnology sector, and may lead to improved medical, diagnostic, and bioremediation capacity.Read moreRead less
Finding the missing links in salt and water transport in plants. Grain crops and horticultural plants use proteins called aquaporins to move water across cell membranes, but a group of these proteins can also transport some important nutrient ions as well as toxic sodium ions. This project aims to reveal the molecular pathways that regulate water and ion transport via aquaporins using advanced techniques in biophysics and molecular biology. These results will provide novel insights into how plan ....Finding the missing links in salt and water transport in plants. Grain crops and horticultural plants use proteins called aquaporins to move water across cell membranes, but a group of these proteins can also transport some important nutrient ions as well as toxic sodium ions. This project aims to reveal the molecular pathways that regulate water and ion transport via aquaporins using advanced techniques in biophysics and molecular biology. These results will provide novel insights into how plants coordinate and adapt to changing water and salt conditions, addressing a missing link in how ions and water move in and out of plant vacuoles. Benefits include an expanded, innovative range of targets for plant breeding programs to improve plant productivity in our changing climate.Read moreRead less
The geochemistry of rare earth elements in carbonate melts. This project aims to determine why deposits of rare earth elements, which are critical for modern devices and technologies such as phones, tablets and plasma screens, are associated with carbonate magmas. The global supply of these critical metals is geopolitically unstable and, although Australia has significant reserves, there is very limited production. By improving our understanding of the geochemical behaviour of the rare earths th ....The geochemistry of rare earth elements in carbonate melts. This project aims to determine why deposits of rare earth elements, which are critical for modern devices and technologies such as phones, tablets and plasma screens, are associated with carbonate magmas. The global supply of these critical metals is geopolitically unstable and, although Australia has significant reserves, there is very limited production. By improving our understanding of the geochemical behaviour of the rare earths this project aims to develop new reverse-engineering methods for their extraction, which will improve the security of supply of these elements and enhance Australia's role in high-tech industries. The project will enhance the profitability of the Australian resources sector through improved extraction economics and will secure the supply of these critical metals for Australian high-tech industries and export. The outcomes will be targeted initially at junior resource companies that are not yet profitable.Read moreRead less
Revealing molecular detail of DNA triplexes to underpin antigene technology. Variations from the classic DNA double helix structure are proposed to play key roles in a range of cellular processes, particularly gene regulation. However, the biological function and therapeutic potential of these unusual DNA structures are poorly explored, since the fundamental molecular details which govern their formation and interactions with cellular machinery are not well described. This project aims to develo ....Revealing molecular detail of DNA triplexes to underpin antigene technology. Variations from the classic DNA double helix structure are proposed to play key roles in a range of cellular processes, particularly gene regulation. However, the biological function and therapeutic potential of these unusual DNA structures are poorly explored, since the fundamental molecular details which govern their formation and interactions with cellular machinery are not well described. This project aims to develop innovative methods to investigate, and importantly modulate, DNA and RNA triple helix assembly, specificity and molecular interactions. Resulting insights will underpin novel approaches to gene regulation, principally in the context of designing new antibacterial agents to address the antibacterial resistance problem.Read moreRead less
How archaeology can transform living in space. This project aims to investigate human engagement with material culture in the extreme environment of space by applying archaeological methods to the habitation design of the International Space Station. The project will use NASA data to record astronaut interactions with objects and spaces over time. The project expects to remedy deficiencies in previous psychological and engineering design research by taking a deep-time perspective on how a cultur ....How archaeology can transform living in space. This project aims to investigate human engagement with material culture in the extreme environment of space by applying archaeological methods to the habitation design of the International Space Station. The project will use NASA data to record astronaut interactions with objects and spaces over time. The project expects to remedy deficiencies in previous psychological and engineering design research by taking a deep-time perspective on how a culture develops in a microgravity environment. The results are intended to identify how humans adapt to space technology and can be applied in the future design of long duration space missions to maximise both survival and efficiency.Read moreRead less
Bio-inspired molecular electronics: from nanoscience to nanotechnology. This project aims to investigate electron transport in naturally occurring peptides, while exploiting their electronic properties to promote the design and development of functional bio-inspired molecular electronic devices. Molecular electronics is at the forefront of international interdisciplinary research, with its significance and necessity stemming from the inevitable physical limitations of existing silicon-based elec ....Bio-inspired molecular electronics: from nanoscience to nanotechnology. This project aims to investigate electron transport in naturally occurring peptides, while exploiting their electronic properties to promote the design and development of functional bio-inspired molecular electronic devices. Molecular electronics is at the forefront of international interdisciplinary research, with its significance and necessity stemming from the inevitable physical limitations of existing silicon-based electronics. This project aims to establish a foundation to advance fundamental knowledge in this area, which will lead to the design and development of functional bio-inspired molecular electronic devices.Read moreRead less
Development of efficient CRISPR gene drives in mice. This project aims to generate new tools for vertebrate pest management through development of cutting-edge gene drive technology in mice. Vertebrate pests cost Australia over $1 billion each year in agricultural losses and environmental damage and novel strategies are required to tackle this challenge. Newly developed “gene drives”, which can rapidly spread through populations, have enormous potential for the sustained management and even erad ....Development of efficient CRISPR gene drives in mice. This project aims to generate new tools for vertebrate pest management through development of cutting-edge gene drive technology in mice. Vertebrate pests cost Australia over $1 billion each year in agricultural losses and environmental damage and novel strategies are required to tackle this challenge. Newly developed “gene drives”, which can rapidly spread through populations, have enormous potential for the sustained management and even eradication of pests. This project aims to develop gene drive technology in mice as a prototypical vertebrate pest species. The project will potentially deliver valuable tools that directly impact Australia’s Science and Research Priority on Food.Read moreRead less
Creating pH-sensitive self-healing concrete using sludge waste for sewers. In Australia, our 117,000 km of concrete sewer pipes are currently internally corroding at a depth rate of 1-3 mm per annum. The repair of deteriorated concrete is costly and often short-lived. Based on an advanced composite technology, this project will develop a pH-sensitive self-healing concrete that can repair itself without human intervention at the early stage of corrosion. Sludge waste from drinking water treatment ....Creating pH-sensitive self-healing concrete using sludge waste for sewers. In Australia, our 117,000 km of concrete sewer pipes are currently internally corroding at a depth rate of 1-3 mm per annum. The repair of deteriorated concrete is costly and often short-lived. Based on an advanced composite technology, this project will develop a pH-sensitive self-healing concrete that can repair itself without human intervention at the early stage of corrosion. Sludge waste from drinking water treatment will be utilised as a healing agent to mitigate the corrosion. Combined experiments and molecular dynamics simulation will uncover all aspects of the healing process to enable the practical application of this technology. The findings will extend the lifetime of concrete structures and promote a circular economy.Read moreRead less
Can parasites cause host population divergence? . Parasites have been proposed to be drivers of population divergence, and ultimately speciation, yet the dynamics of this process are not well understood. This project will utilise new genomic techniques, novel hybrid zone analyses, and data on mate choice, to investigate the hypothesis that parasites drive population divergence through an interaction with immune response genes in the sleepy lizard Tiliqua rugosa. This species provides an unpreced ....Can parasites cause host population divergence? . Parasites have been proposed to be drivers of population divergence, and ultimately speciation, yet the dynamics of this process are not well understood. This project will utilise new genomic techniques, novel hybrid zone analyses, and data on mate choice, to investigate the hypothesis that parasites drive population divergence through an interaction with immune response genes in the sleepy lizard Tiliqua rugosa. This species provides an unprecedented system, backed by 37 years of long term host-parasite and behavioural data, and recent genetic analyses. This project intends to produce significant data to allow an examination of the early stages of host-parasite evolution in action, providing novel insights into the speciation process. Read moreRead less
Light Powered Materials for Producing Chemical Fuels. This project aims to develop a hybrid, solar-powered catalytic material for the manufacture of liquid hydrocarbon chemicals, without consuming external heating. The key concept is to transform hydrogen and carbon monoxide into long-chain hydrocarbons over hybrid materials that can convert light energy into heat and simultaneously catalyze the chemical transformation. Investigations on the relations between material synthesis, nanostructures, ....Light Powered Materials for Producing Chemical Fuels. This project aims to develop a hybrid, solar-powered catalytic material for the manufacture of liquid hydrocarbon chemicals, without consuming external heating. The key concept is to transform hydrogen and carbon monoxide into long-chain hydrocarbons over hybrid materials that can convert light energy into heat and simultaneously catalyze the chemical transformation. Investigations on the relations between material synthesis, nanostructures, and performance of the new catalysis processes will be conducted using experiments and theoretical computation. Expected outcomes include low cost and efficient materials for solar-to-fuel conversion, will provide benefits to low-carbon living, new clean energy resource and environmental protections.Read moreRead less