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A nanoengineered solution to drug delivery in bone. This project presents an exciting new approach of applying nanotechnology to bone research. By combining our expertise in nanoengineering of new materials, mathematical modelling and bone biology, this project will result in a well-characterised model for drug delivery into bone and lead to a new therapeutic approach for treating bone diseases.
Inorganic/organic Hybrids for flexible thermoelectric generators. Flexible thermoelectric generators can directly harvest electricity from body heat, offering a new technology for wearable electronics, but their unsatisfied performance limits their applications. This project aims to design high-efficient and mechanically robust flexible thermoelectric devices based on novel hybrids with quantum dots and conducting polymers as key components. The key breakthrough is to establish unique devices wi ....Inorganic/organic Hybrids for flexible thermoelectric generators. Flexible thermoelectric generators can directly harvest electricity from body heat, offering a new technology for wearable electronics, but their unsatisfied performance limits their applications. This project aims to design high-efficient and mechanically robust flexible thermoelectric devices based on novel hybrids with quantum dots and conducting polymers as key components. The key breakthrough is to establish unique devices with record-high thermoelectric efficiency and to illustrate the underlying mechanisms for searching new-type flexible thermoelectrics. The expected outcomes will lead to innovative technology for energy conversion and advanced manufacturing and place Australia at the forefront of energy and manufacturing fields.Read moreRead less
Rotational Degrees Of Freedom In Modelling Of Materials With Intrinsic Length Scale. In many applications, from nanotechnology to construction and mining, the modelled objects are not large enough as compared to the material constituents for classical continuum modelling to be adequate, but yet encompass too many elements for comfortable particle-type computer simulation. Generalised continua would offer a viable option if a rational method of their construction for each intrinsic material struc ....Rotational Degrees Of Freedom In Modelling Of Materials With Intrinsic Length Scale. In many applications, from nanotechnology to construction and mining, the modelled objects are not large enough as compared to the material constituents for classical continuum modelling to be adequate, but yet encompass too many elements for comfortable particle-type computer simulation. Generalised continua would offer a viable option if a rational method of their construction for each intrinsic material structure were at hand. The project aims at developing the necessary homogenisation procedure and constructing generalised (Cosserat) continuum models of deformation, wave propagation and impact fracture in particulate and layered materials such as multi-wall nanotubes, fullerenes, particulate composites and layered rock masses.Read moreRead less
Electrostatic catalysis from single-molecule events to macroscopic systems. Electrostatics has important applications in day-to-day technologies, from recycling plastics to photocopying, but the exploration of how static charges affect chemical bonds and bonding is still in its infancy. This project aims to demonstrate the experimental links between the magnitude and polarity of an external electric field and chemical rates, expanding our understanding of chemical reactivity and transforming our ....Electrostatic catalysis from single-molecule events to macroscopic systems. Electrostatics has important applications in day-to-day technologies, from recycling plastics to photocopying, but the exploration of how static charges affect chemical bonds and bonding is still in its infancy. This project aims to demonstrate the experimental links between the magnitude and polarity of an external electric field and chemical rates, expanding our understanding of chemical reactivity and transforming our view of catalysis. By investigating the role of static electricity over systems selected from different sub-disciplines of chemistry, the project will derive the ground and selection rules for reactivity and selectivity by electrostatics. The project is expected to show that for chemical reactions of practical and conceptual value a specific catalyst can be replaced by a generic electric field stimulus, an invisible catalyst, enabling cleaner and cheaper opportunities that current technologies cannot fulfil.Read moreRead less
Understanding graphitization: developing a model for activated carbons. For over 60 years it has remained a puzzle why some carbons graphitise under heating while others do not. The question is of practical importance as oxidation of non-graphitising carbons produces activated carbon, a product of high value with industrial, medical and environmental applications. Using computational and experimental techniques the project will study the graphitisation process and pinpoint the structural element ....Understanding graphitization: developing a model for activated carbons. For over 60 years it has remained a puzzle why some carbons graphitise under heating while others do not. The question is of practical importance as oxidation of non-graphitising carbons produces activated carbon, a product of high value with industrial, medical and environmental applications. Using computational and experimental techniques the project will study the graphitisation process and pinpoint the structural elements which inhibit it. Based on these findings the project aims to develop a nanoscale atomistic model for activated carbons. This is expected to be an important contribution to the field of chemical engineering in which current models of activated carbon neglect either curvature in the network or the presence of oxygen.Read moreRead less
Magnetofection In An Oscillating Magnetic Field. The success of genetic engineering is largely dependent on the ability of transfection agents to deliver genes. Low transfection efficiency is now widely recognised as a critical bottleneck to successful gene delivery. The recent emphasis on the development of nanoscale delivery agents has led to new physics and chemistry-based techniques, which take advantage of charge interactions and energetic processes. This multidisciplinary project aims to a ....Magnetofection In An Oscillating Magnetic Field. The success of genetic engineering is largely dependent on the ability of transfection agents to deliver genes. Low transfection efficiency is now widely recognised as a critical bottleneck to successful gene delivery. The recent emphasis on the development of nanoscale delivery agents has led to new physics and chemistry-based techniques, which take advantage of charge interactions and energetic processes. This multidisciplinary project aims to address this highly significant problem by developing a novel methodology to manipulate nanoparticles under the influence of an oscillating magnetic field to achieve high transfection efficiencies in a highly relevant model of epigenetic reprogramming.Read moreRead less
Investigation of vertical magneto-transport in infrared detector structures based on InAs/GaSb type-II superlattices. Infrared sensors and systems are finding increasing use in Australia's core industries: particularly defence, mineral exploration, environmental monitoring, precision agriculture, homeland security, and medical diagnostics. Due to the reduced cooling requirements, the Infrared detector structures to be investigated in this project have the potential to deliver high performance in ....Investigation of vertical magneto-transport in infrared detector structures based on InAs/GaSb type-II superlattices. Infrared sensors and systems are finding increasing use in Australia's core industries: particularly defence, mineral exploration, environmental monitoring, precision agriculture, homeland security, and medical diagnostics. Due to the reduced cooling requirements, the Infrared detector structures to be investigated in this project have the potential to deliver high performance infrared technology at a significantly lower cost and, hence, widening its applications. The new science proposed in this project, and new technological knowledge expected from its application, will allow Australian researchers to participate and significantly contribute to the international effort in this field and to exploit any developed intellectual property. Read moreRead less
Resonant Nanostructures for Adaptive Optoelectronics. The science and technology outcomes of this project will create new, innovative solutions to current and future challenges facing industry, the community, and Australian national and strategic interests. Adaptive, resonant optoelectronics technologies will create new industries and enable, for the first time, advanced, low-cost, hand-held, spectroscopic systems for chemical/biological/process sensing for industries as diverse as food processi ....Resonant Nanostructures for Adaptive Optoelectronics. The science and technology outcomes of this project will create new, innovative solutions to current and future challenges facing industry, the community, and Australian national and strategic interests. Adaptive, resonant optoelectronics technologies will create new industries and enable, for the first time, advanced, low-cost, hand-held, spectroscopic systems for chemical/biological/process sensing for industries as diverse as food processing to pharmaceuticals manufacturing, portable biomedical diagnostics, and precision agriculture. The technologies will enhance Australia's ability to address defence and security needs related to surveillance, chemical/biological threat monitoring, border protection, and target identification.
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Targeted enzymatic treatment of the injured central nervous system using innovative nanotechnology. Nanotechnology and other frontier areas in science have exciting potential to solve major challenges of the 21st century, including health. The proposed research provides the real possibility of discovering ways to alleviate the many complex problems associated with neurotrauma following, for example, brain and spinal cord injury. Current delivery of therapeutics do not work effectively and new ap ....Targeted enzymatic treatment of the injured central nervous system using innovative nanotechnology. Nanotechnology and other frontier areas in science have exciting potential to solve major challenges of the 21st century, including health. The proposed research provides the real possibility of discovering ways to alleviate the many complex problems associated with neurotrauma following, for example, brain and spinal cord injury. Current delivery of therapeutics do not work effectively and new approaches are urgently needed. The recently established powerful multidisciplinary research team combines expertise in nanotechnology, glycobiology and neuroscience to develop novel, safe ways to deliver therapeutic enzymes over biological time-courses. We aim to make broken connections work again, while providing quality research training.Read moreRead less
Using magnetic nanotechnology to aid recovery from neurotrauma. Nanotechnology is an exciting new field that holds great promise to solve challenging health issues including neurotrauma associated with brain and spinal cord injury. Current methods to deliver drugs and stimulate tissue repair after neurotrauma do not work effectively and new approaches are urgently need. The recently established research team brings together expertise in nanotechnology and neuroscience to develop new, safe ways t ....Using magnetic nanotechnology to aid recovery from neurotrauma. Nanotechnology is an exciting new field that holds great promise to solve challenging health issues including neurotrauma associated with brain and spinal cord injury. Current methods to deliver drugs and stimulate tissue repair after neurotrauma do not work effectively and new approaches are urgently need. The recently established research team brings together expertise in nanotechnology and neuroscience to develop new, safe ways to deliver drugs and stimulate tissue repair after neurotrauma, and provide quality research training. Specifically designed nanomaterials will deliver drugs slowly over time and act as scaffolds to stop cells dying and stimulate them to restore broken connections and work again. Read moreRead less